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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases cleavageEXP 6480464CTDLipopolysaccharides results in increased cleavage of CASP9 proteinPMID:25557508 PMID:31486215 PMID:31777165 PMID:34859534
Casp9increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of CASP9 proteinPMID:30084861
Casp9multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]]; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of CASP9 protein; [Lipopolysaccharides co-treated with TNF protein] results in increased expression of CASP9 protein; [MK 2206 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of CASP9 protein; Apigenin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]; Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]; IGF1R protein affects the reaction [Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]]; MIR16 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]; tyrphostin AG 1024 inhibits the reaction [Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]]PMID:25557508 PMID:31486215 PMID:31777165 PMID:34859534 PMID:36049518
Casp9increases activityISOCasp9 (Mus musculus)6480464CTDLipopolysaccharides results in increased activity of CASP9 proteinPMID:23170834 PMID:30261164
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDLipopolysaccharides results in increased activity of CASP9 proteinPMID:20848084
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDLipopolysaccharides results in increased cleavage of CASP9 proteinPMID:32048402
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of CASP9 proteinPMID:21844306
Casp9multiple interactionsISOCasp9 (Mus musculus)6480464CTD[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP9 protein; [Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP9 protein modified form; gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP9 protein]; gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP9 protein modified form]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP9 protein]; sesamol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP9 protein]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP9 protein]]PMID:20558151 PMID:23170834 PMID:30261164
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Lipopolysaccharides results in increased activity of CASP9 protein]; HOXA-AS2 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]; MIR106B mRNA inhibits the reaction [HOXA-AS2 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]]PMID:20848084 PMID:32048402
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