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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:3193
Term: brucine
Definition: A monoterpenoid indole alkaloid that has formula C23H26N2O4.
Chemical ID: MESH:C083806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases activityISORGD:691476480464CTD[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein brucine results in increased activity of CASP9 protein

PMID:16443926 PMID:21684292
Casp9multiple interactionsISORGD:691476480464CTDbrucine results in increased activity of and results in increased cleavage of CASP9 protein Cyclosporine inhibits the reaction [[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein] Cyclosporine inhibits the reaction [brucine results in increased activity of and results in increased cleavage of CASP9 protein]

PMID:16443926
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