RGD Reference Report - Genetic expression profiles and chromosomal alterations in sporadic breast cancer in Mexican women. - Rat Genome Database

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Genetic expression profiles and chromosomal alterations in sporadic breast cancer in Mexican women.

Authors: Valladares, A  Hernandez, NG  Gomez, FS  Curiel-Quezada, E  Madrigal-Bujaidar, E  Vergara, MD  Martinez, MS  Arenas Aranda, DJ 
Citation: Valladares A, etal., Cancer Genet Cytogenet. 2006 Oct 15;170(2):147-51.
RGD ID: 2290492
Pubmed: PMID:17011986   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cancergencyto.2006.06.002   (Journal Full-text)

Breast cancer is the second-leading cause of death among Mexican women >35 years of age. At the molecular level, changes in many genetic pathways have been reported to be associated with this neoplasm. To analyze these changes, we determined gene expression profiles and chromosomal structural alterations in tumors from Mexican women. We obtained mRNA to identify expression profiles with microarray technology, and DNA to determine amplifications and deletions, in 10 fresh sporadic breast tumor biopsies without treatment, as well as in 10 nonaffected breast tissues. Expression profiles were compared with genetic changes observed by comparative genomic hybridization (CGH). We compared the expression profiles against the structural alterations from the studied genes by means of microarrays; at least 17 of these genes correlated with DNA copy number alterations. We found that the following genes were overexpressed: LAMC1, PCTK3, CCNC, CCND1, FGF3, PCTK2, L1CAM, BGN, and PLXNB3 (alias PLEXR). Underexpressed genes included CASP9, FGR, TP73, HSPG2, and ERCC1; genes turned off included FRAP1, EPHA2 (previously ECK), IL12A, E2F5, TNFRSF10B, TNFRSF10A, EFNB3, and BCL2. The results will allow us, in the near future, to outline genes that could serve as diagnostic, prognostic, or target therapy markers for the Mexican population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
breast cancer  IEP 2290492mRNA:decreased expression:breastRGD 
breast cancer  ISOCASP9 (Homo sapiens)2290492; 2290492mRNA:decreased expression:breastRGD 
breast ductal carcinoma  IEP 2290492; 2290492mRNA:decreased expression:breastRGD 
breast ductal carcinoma  ISOTNFRSF10A (Homo sapiens)2290492; 2290492mRNA:decreased expression:breastRGD 
breast ductal carcinoma  ISOTP73 (Homo sapiens)2290492; 2290492mRNA:decreased expression:breastRGD 

Objects Annotated

Genes (Rattus norvegicus)
Casp9  (caspase 9)
Tnfrsf10b  (TNF receptor superfamily member 10b)
Tp73  (tumor protein p73)

Genes (Mus musculus)
Casp9  (caspase 9)
Tnfrsf10b  (tumor necrosis factor receptor superfamily, member 10b)
Trp73  (transformation related protein 73)

Genes (Homo sapiens)
CASP9  (caspase 9)
TNFRSF10A  (TNF receptor superfamily member 10a)
TP73  (tumor protein p73)

Objects referenced in this article
Gene TNFRSF10B TNF receptor superfamily member 10b Homo sapiens

Additional Information