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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:32497
Term: thioacetamide
Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID: MESH:D013853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9decreases expressionEXP 6480464CTDThioacetamide results in decreased expression of CASP9 mRNAPMID:29133031 PMID:34492290
Casp9increases expressionEXP 6480464CTDThioacetamide results in increased expression of CASP9 proteinPMID:37150287
Casp9multiple interactionsEXP 6480464CTD[Berberine co-treated with Thioacetamide] results in increased expression of CASP9 mRNA; [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CASP9 mRNA; chloroquine diphosphate inhibits the reaction [Thioacetamide results in decreased expression of CASP9 mRNA]; chloroquine diphosphate promotes the reaction [Doxorubicin inhibits the reaction [Thioacetamide results in decreased expression of CASP9 mRNA]]; Doxorubicin inhibits the reaction [Thioacetamide results in decreased expression of CASP9 mRNA]; Doxorubicin promotes the reaction [chloroquine diphosphate inhibits the reaction [Thioacetamide results in decreased expression of CASP9 mRNA]]; indole-3-carbinol inhibits the reaction [Thioacetamide results in increased expression of CASP9 protein]PMID:23830814 PMID:29133031 PMID:30138605 PMID:37150287
Casp9increases activityISOCasp9 (Mus musculus)6480464CTDThioacetamide results in increased activity of CASP9 proteinPMID:20713078
Casp9multiple interactionsISOCasp9 (Mus musculus)6480464CTDTXNIP gene mutant form inhibits the reaction [Thioacetamide results in increased activity of CASP9 protein]PMID:20713078
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