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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:42768
Term: geneticin
Definition: An aminoglycoside antibiotic produced by Micromonospora rhodorangea. It blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.
Chemical ID: MESH:C010680
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDantibiotic G 418 results in increased activity of CASP9 proteinPMID:15241557
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDbenzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [antibiotic G 418 results in increased activity of CASP9 protein]PMID:15241557
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