GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp9 | increases expression | EXP | | 6480464 | CTD | Copper results in increased expression of CASP9 protein | PMID:30556269 | Casp9 | multiple interactions | EXP | | 6480464 | CTD | [Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased cleavage of CASP9 protein; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased cleavage of CASP9 protein] | PMID:22085843 | Casp9 | increases activity | ISO | Casp9 (Mus musculus) | 6480464 | CTD | Copper analog results in increased activity of CASP9 protein | PMID:22000994 | Casp9 | increases cleavage | ISO | Casp9 (Mus musculus) | 6480464 | CTD | Copper analog results in increased cleavage of CASP9 protein | PMID:21319953 | Casp9 | multiple interactions | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | [[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]; [Chelating Agents binds to Copper] which results in increased cleavage of CASP9 protein; [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP9 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP9 protein; [Disulfiram binds to Copper] which results in increased activity of CASP9 protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP9 protein; [Thiosemicarbazones binds to Copper] which results in increased expression of CASP9 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP9 protein] | PMID:17327230 PMID:20931265 PMID:22951949 PMID:24690739 PMID:29115570 PMID:30911355 | | ||||||||||||||||||||||
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