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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:25434
Term: bis(2-chloroethyl) sulfide
Definition: An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.
Chemical ID: MESH:D009151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases cleavageEXP 6480464CTDMustard Gas results in increased cleavage of CASP9 proteinPMID:20659490
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDMustard Gas results in increased activity of CASP9 proteinPMID:12482751 PMID:16738803 PMID:20226831
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDMustard Gas results in increased cleavage of CASP9 proteinPMID:20435105 PMID:25448276
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDbenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Mustard Gas results in increased activity of CASP9 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Mustard Gas results in increased activity of CASP9 protein]; BRCA2 protein inhibits the reaction [Mustard Gas results in increased cleavage of CASP9 protein]; CALM1 protein promotes the reaction [Mustard Gas results in increased cleavage of and results in increased activity of CASP9 protein]; Mustard Gas results in increased cleavage of and results in increased activity of CASP9 protein; pifithrin promotes the reaction [Mustard Gas results in increased cleavage of CASP9 protein]PMID:16935404 PMID:18161513 PMID:20226831 PMID:20435105 PMID:25448276
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