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altered signaling pathway - Ontology Report - Rat Genome Database

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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:altered signaling pathway
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Accession:PW:0000264 term browser browse the term
Definition:Those signaling pathways that deviate from what their normal course should be. Aberrant signaling pathways, alone or in combination with other pathways underlie many conditions, disorders and/or diseases.

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altered androgen signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor ISO RGD PMID:18008377 PMID:23759327 RGD:2326139 RGD:8693397 NCBI chrNW_004936635:485,903...647,820
Ensembl chrNW_004936635:485,903...647,932 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ISO RGD PMID:23759327 RGD:8693397 NCBI chrNW_004936496:14,844,923...15,102,922
Ensembl chrNW_004936496:14,844,855...15,016,454 		JBrowse link
G Ncor2 nuclear receptor corepressor 2 ISO RGD PMID:23759327 RGD:8693397 NCBI chrNW_004936558:658,723...775,263
Ensembl chrNW_004936558:677,610...775,288 		JBrowse link
altered epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor ISO RGD PMID:19506583 RGD:5490965 NCBI chrNW_004936563:1,058,803...1,181,393 JBrowse link
G Egfr epidermal growth factor receptor ISO RGD PMID:19506583 PMID:20519133 PMID:20951313 RGD:5133241 RGD:5133242 RGD:5490965 NCBI chrNW_004936678:365,005...560,546
Ensembl chrNW_004936678:365,834...436,528 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:19078924 PMID:21277552 RGD:4143515 RGD:5133243 NCBI chrNW_004936490:14,887,062...14,910,038
Ensembl chrNW_004936490:14,887,043...14,909,956 		JBrowse link
G Tgfa transforming growth factor alpha ISO RGD PMID:19506583 RGD:5490965 NCBI chrNW_004936491:14,659,089...14,758,614
Ensembl chrNW_004936491:14,657,100...14,758,848 		JBrowse link
altered Erk5 MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k5 mitogen-activated protein kinase kinase 5 ISO RGD PMID:16376520 RGD:2298532 NCBI chrNW_004936471:27,491,255...27,728,572
Ensembl chrNW_004936471:27,491,342...27,728,607 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO RGD PMID:16376520 RGD:2298532 NCBI chrNW_004936881:372,713...377,655
Ensembl chrNW_004936881:372,810...377,214 		JBrowse link
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 PMID:18098337 PMID:20951313 PMID:21277552 RGD:2293882 RGD:2298531 RGD:5133242 RGD:5133243 NCBI chrNW_004936592:4,728,371...4,833,830
Ensembl chrNW_004936592:4,737,011...4,834,664 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO RGD PMID:16112461 PMID:18772397 PMID:19078924 PMID:19506583 PMID:20951313 RGD:2306732 RGD:4143515 RGD:5133242 RGD:5490965 RGD:5490966 NCBI chrNW_004936548:2,078,568...2,113,877
Ensembl chrNW_004936548:2,079,036...2,110,523 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 ISO RGD PMID:20951313 PMID:21277552 RGD:5133242 RGD:5133243 NCBI chrNW_004936471:26,589,251...26,628,302
Ensembl chrNW_004936471:26,589,161...26,628,302 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 RGD:2293882 NCBI chrNW_004936602:1,089,979...1,114,376
Ensembl chrNW_004936602:1,051,205...1,117,096 		JBrowse link
altered Hedgehog signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Boc BOC cell adhesion associated, oncogene regulated ISO RGD PMID:18772397 RGD:5490966 NCBI chrNW_004936536:813,984...890,766
Ensembl chrNW_004936536:813,949...891,065 		JBrowse link
G Dhh desert hedgehog signaling molecule ISO RGD PMID:11118005 RGD:634737 NCBI chrNW_004936512:6,885,607...6,889,955
Ensembl chrNW_004936512:6,885,607...6,889,992 		JBrowse link
G Gli1 GLI family zinc finger 1 ISO RGD PMID:18772397 PMID:21186299 RGD:5490966 RGD:5491005 NCBI chrNW_004936646:1,622,308...1,629,787
Ensembl chrNW_004936646:1,622,308...1,629,779 		JBrowse link
G Gli3 GLI family zinc finger 3 ISO RGD PMID:18772397 RGD:5490966 NCBI chrNW_004936478:17,129,922...17,403,630
Ensembl chrNW_004936478:17,126,911...17,403,011 		JBrowse link
G Lrp2 LDL receptor related protein 2 ISO RGD PMID:18772397 RGD:5490966 NCBI chrNW_004936469:10,245,001...10,438,933
Ensembl chrNW_004936469:10,244,881...10,438,935 		JBrowse link
G Shh sonic hedgehog signaling molecule ISO RGD PMID:19506583 RGD:5490965 NCBI chrNW_004936527:10,033,095...10,042,713
Ensembl chrNW_004936527:10,033,299...10,042,599 		JBrowse link
G Smo smoothened, frizzled class receptor ISO RGD PMID:9422511 RGD:704355 NCBI chrNW_004936579:5,893,064...5,917,021
Ensembl chrNW_004936579:5,892,542...5,917,281 		JBrowse link
altered hypoxia inducible factor pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vhl von Hippel-Lindau tumor suppressor ISO RGD PMID:22035299 RGD:6907133 NCBI chrNW_004936602:3,135,790...3,140,622 JBrowse link
altered insulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins insulin ISO RGD PMID:9809695 RGD:2313694 NCBI chrNW_004936816:1,002,137...1,003,357
Ensembl chrNW_004936816:1,002,137...1,003,357 		JBrowse link
G Insr insulin receptor ISO RGD PMID:9809695 RGD:2313694 NCBI chrNW_004936588:4,345,306...4,453,380
Ensembl chrNW_004936588:4,345,306...4,453,668 		JBrowse link
altered insulin-like growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1 insulin like growth factor 1 ISO RGD PMID:15996002 RGD:1580474 NCBI chrNW_004936492:11,709,623...11,784,028
Ensembl chrNW_004936492:11,709,222...11,778,351 		JBrowse link
altered integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ilk integrin linked kinase ISO RGD PMID:18772397 RGD:5490966 NCBI chrNW_004936842:661,961...667,993
Ensembl chrNW_004936842:661,996...667,993 		JBrowse link
G Itga1 integrin subunit alpha 1 ISO RGD PMID:10536667 RGD:1302875 NCBI chrNW_004936480:14,442,481...14,591,574
Ensembl chrNW_004936480:14,443,685...14,591,380 		JBrowse link
G Itga11 integrin subunit alpha 11 ISO RGD PMID:18772397 RGD:5490966 NCBI chrNW_004936471:28,140,602...28,255,239
Ensembl chrNW_004936471:28,140,503...28,255,462 		JBrowse link
G Itga4 integrin subunit alpha 4 ISO RGD PMID:11782963 PMID:18772397 RGD:1302879 RGD:5490966 NCBI chrNW_004936509:10,215,283...10,293,653
Ensembl chrNW_004936509:10,215,283...10,292,252 		JBrowse link
G Itga8 integrin subunit alpha 8 ISO RGD PMID:9054500 RGD:40903006 NCBI chrNW_004936574:5,985,181...6,155,067
Ensembl chrNW_004936574:5,984,939...6,155,164 		JBrowse link
G Itga9 integrin subunit alpha 9 ISO RGD PMID:18772397 RGD:5490966 NCBI chrNW_004936473:26,875,337...27,188,747
Ensembl chrNW_004936473:26,876,671...27,184,795 		JBrowse link
altered Jak-Stat signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak2 Janus kinase 2 ISO RGD PMID:12032773 RGD:1357939 NCBI chrNW_004936503:111,722...243,627
Ensembl chrNW_004936503:110,963...241,867 		JBrowse link
G Jak3 Janus kinase 3 ISO RGD PMID:12032773 RGD:1357939 NCBI chrNW_004936596:3,212,593...3,224,426
Ensembl chrNW_004936596:3,212,593...3,224,048 		JBrowse link
altered leptin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor ISO increased basal hypothalamic leptin signaling without changes in leptin receptor expression after antisense-mediated hypothalamus-specific Insr knock-down RGD PMID:17585961 RGD:2290473 NCBI chrNW_004936588:4,345,306...4,453,380
Ensembl chrNW_004936588:4,345,306...4,453,668 		JBrowse link
G Lep leptin ISO RGD PMID:11102451 PMID:15703762 RGD:1357910 RGD:61790 NCBI chrNW_004936479:15,394,966...15,411,334
Ensembl chrNW_004936479:15,394,966...15,411,334 		JBrowse link
G Lepr leptin receptor ISO RGD PMID:11102451 PMID:15703762 PMID:17229951 RGD:1357910 RGD:1600611 RGD:61790 NCBI chrNW_004936591:5,771,371...5,846,177
Ensembl chrNW_004936591:5,774,326...5,836,444 		JBrowse link
altered melanocortin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide ISO RGD PMID:15189116 RGD:1357925 NCBI chrNW_004936475:17,927,991...17,929,377
Ensembl chrNW_004936475:17,927,985...17,937,147 		JBrowse link
G Mc4r melanocortin 4 receptor ISO RGD PMID:15189116 RGD:1357925 NCBI chrNW_004936497:4,636,370...4,638,205
Ensembl chrNW_004936497:4,636,758...4,637,759 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 ISO RGD PMID:11874690 PMID:15189116 RGD:1357925 RGD:1357926 NCBI chrNW_004936523:7,009,966...7,050,300
Ensembl chrNW_004936523:7,010,068...7,050,468 		JBrowse link
G Pomc proopiomelanocortin ISO RGD PMID:11874690 PMID:15189116 RGD:1357925 RGD:1357926 NCBI chrNW_004936493:7,060,747...7,065,276
Ensembl chrNW_004936493:7,061,587...7,065,109 		JBrowse link
G Sdc1 syndecan 1 ISO RGD PMID:15189116 RGD:1357925 NCBI chrNW_004936493:11,177,804...11,199,678
Ensembl chrNW_004936493:11,177,708...11,199,804 		JBrowse link
altered Notch signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 ISO RGD PMID:12548545 RGD:1334460 NCBI chrNW_004936871:666,961...670,910
Ensembl chrNW_004936871:666,938...670,916 		JBrowse link
G Numb NUMB endocytic adaptor protein ISO RGD PMID:15492044 RGD:1334451 NCBI chrNW_004936488:2,579,017...2,742,961 JBrowse link
altered Notch signaling pathway involving promoters term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 ISO RGD PMID:12548545 RGD:1334460 NCBI chrNW_004936871:666,961...670,910
Ensembl chrNW_004936871:666,938...670,916 		JBrowse link
altered Notch signaling pathway involving the macromolecules modifying the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Numb NUMB endocytic adaptor protein ISO RGD PMID:15492044 RGD:1334451 NCBI chrNW_004936488:2,579,017...2,742,961 JBrowse link
G Psen2 presenilin 2 ISO C. elegans transgenics expressing wild-type and mutant PSEN2 RGD PMID:16474849 RGD:2302525 NCBI chrNW_004936526:3,584,194...3,611,719
Ensembl chrNW_004936526:3,584,188...3,614,074 		JBrowse link
altered Notch signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll3 delta like canonical Notch ligand 3 ISO Mutations in the gene have been associated with Spondylocostal dysostosis RGD PMID:12141422 RGD:1304493 NCBI chrNW_004936661:2,322,531...2,330,150
Ensembl chrNW_004936661:2,322,531...2,329,953 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISO RGD PMID:15057910 RGD:1334443 NCBI chrNW_004936485:8,857,688...8,894,270
Ensembl chrNW_004936485:8,857,669...8,895,315 		JBrowse link
G Notch1 notch receptor 1 ISO Mutations in the dimerization and/or PEST domain have been associated with human acute T-lymphoblastic leukemias RGD PMID:15472075 RGD:1334450 NCBI chrNW_004936669:1,292,016...1,334,061
Ensembl chrNW_004936669:1,292,088...1,332,428 		JBrowse link
G Notch3 notch receptor 3 ISO Mutations are predominantly found in the EGF repeats and clustered within the first five RGD PMID:9388399 RGD:1334441 NCBI chrNW_004936596:5,265,984...5,301,430
Ensembl chrNW_004936596:5,265,999...5,300,429 		JBrowse link
altered p53 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ets1 ETS proto-oncogene 1, transcription factor ISO RGD PMID:22713868 RGD:8663430 NCBI chrNW_004936572:3,728,971...3,795,612
Ensembl chrNW_004936572:3,730,327...3,795,625 		JBrowse link
G Mdm2 MDM2 proto-oncogene ISO RGD PMID:19165225 PMID:23262034 RGD:2316186 RGD:8663434 NCBI chrNW_004936545:6,709,903...6,732,334 JBrowse link
G Mdm4 MDM4 regulator of p53 ISO RGD PMID:23262034 RGD:8663434 NCBI chrNW_004936567:268,151...299,494
Ensembl chrNW_004936567:268,151...299,494 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease ISO RGD PMID:23263379 RGD:8663431 NCBI chrNW_004936674:466,495...528,072
Ensembl chrNW_004936674:466,456...530,317 		JBrowse link
G Nfya nuclear transcription factor Y subunit alpha ISO RGD PMID:22713868 PMID:23263379 RGD:8663430 RGD:8663431 NCBI chrNW_004936476:18,728,575...18,750,917
Ensembl chrNW_004936476:18,725,907...18,750,864 		JBrowse link
G Nfyb nuclear transcription factor Y subunit beta ISO RGD PMID:22713868 PMID:23263379 RGD:8663430 RGD:8663431 NCBI chrNW_004936492:10,359,387...10,377,537 JBrowse link
G Nfyc nuclear transcription factor Y subunit gamma ISO RGD PMID:22713868 PMID:23263379 RGD:8663430 RGD:8663431 NCBI chrNW_004936474:22,368,279...22,432,671
Ensembl chrNW_004936474:22,369,313...22,433,166 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO RGD PMID:22713868 RGD:8663430 NCBI chrNW_004936659:309,530...321,294
Ensembl chrNW_004936659:309,506...321,334 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 ISO RGD PMID:22713868 PMID:23263379 RGD:8663430 RGD:8663431 NCBI chrNW_004936492:115,923...174,614
Ensembl chrNW_004936492:115,821...174,775 		JBrowse link
G Tp53 tumor protein p53 ISO RGD PMID:18772397 PMID:19078924 PMID:19165225 PMID:20951313 PMID:22713868 More... RGD:2316186 RGD:4143515 RGD:5133242 RGD:5490966 RGD:8663430 RGD:8663431 RGD:8693397 NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425 		JBrowse link
G Tp63 tumor protein p63 ISO RGD PMID:22713868 PMID:23263379 RGD:8663430 RGD:8663431 NCBI chrNW_004936578:492,267...705,282
Ensembl chrNW_004936578:491,507...705,729 		JBrowse link
G Tp73 tumor protein p73 ISO RGD PMID:22713868 PMID:23263379 RGD:8663430 RGD:8663431 NCBI chrNW_004936737:171,894...211,464
Ensembl chrNW_004936737:172,467...211,464 		JBrowse link
G Vdr vitamin D receptor ISO RGD PMID:22713868 RGD:8663430 NCBI chrNW_004936512:5,741,836...5,800,999
Ensembl chrNW_004936512:5,740,748...5,801,109 		JBrowse link
altered phosphatidylinositol 3-kinase signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO RGD PMID:23759327 RGD:8693397 NCBI chrNW_004936566:3,924,013...3,951,052
Ensembl chrNW_004936566:3,923,934...3,951,073 		JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:23759327 RGD:8693397 NCBI chrNW_004936735:1,252,414...1,338,318
Ensembl chrNW_004936735:1,252,414...1,338,323 		JBrowse link
altered phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:18955974 PMID:21277552 RGD:2313763 RGD:5133243 NCBI chrNW_004936621:620,163...639,115
Ensembl chrNW_004936621:620,074...639,093 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO RGD PMID:15166380 PMID:18955974 PMID:19506583 RGD:2313408 RGD:2313763 RGD:5490965 NCBI chrNW_004936661:2,652,568...2,694,039
Ensembl chrNW_004936661:2,652,566...2,694,086 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 ISO RGD PMID:18955974 RGD:2313763 NCBI chrNW_004936526:6,944,056...7,201,226
Ensembl chrNW_004936526:6,944,005...7,200,583 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO RGD PMID:18955974 PMID:19078924 PMID:20951313 PMID:21277552 RGD:2313763 RGD:4143515 RGD:5133242 RGD:5133243 NCBI chrNW_004936566:3,924,013...3,951,052
Ensembl chrNW_004936566:3,923,934...3,951,073 		JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:18008377 PMID:18955974 PMID:19078924 PMID:19506583 PMID:20951313 RGD:2313763 RGD:2326139 RGD:4143515 RGD:5133242 RGD:5490965 NCBI chrNW_004936735:1,252,414...1,338,318
Ensembl chrNW_004936735:1,252,414...1,338,323 		JBrowse link
altered Reelin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dab1 DAB adaptor protein 1 ISO RGD PMID:12670697 PMID:12764038 PMID:16266828 RGD:1358468 RGD:2324967 RGD:727518 NCBI chrNW_004936522:3,498,395...4,612,560
Ensembl chrNW_004936522:4,333,647...4,616,044 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO RGD PMID:12778121 RGD:2324970 NCBI chrNW_004936679:388,500...588,518
Ensembl chrNW_004936679:387,387...443,880 		JBrowse link
G Itga3 integrin subunit alpha 3 ISO RGD PMID:15583703 RGD:2325851 NCBI chrNW_004936490:11,553,904...11,583,387
Ensembl chrNW_004936490:11,553,861...11,583,380 		JBrowse link
G Itgb1 integrin subunit beta 1 ISO RGD PMID:15583703 RGD:2325851 NCBI chrNW_004936574:1,465,981...1,495,717
Ensembl chrNW_004936574:1,465,897...1,495,762 		JBrowse link
G Lrp8 LDL receptor related protein 8 ISO RGD PMID:19846452 RGD:2324974 NCBI chrNW_004936522:7,740,887...7,820,488
Ensembl chrNW_004936522:7,740,887...7,816,297 		JBrowse link
G Pafah1b1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 ISO RGD PMID:17330141 RGD:4107040 NCBI chrNW_004936538:8,612,142...8,693,698
Ensembl chrNW_004936538:8,612,049...8,694,015 		JBrowse link
G Pafah1b2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 ISO RGD PMID:17330141 RGD:4107040 NCBI chrNW_004936542:2,390,904...2,417,596
Ensembl chrNW_004936542:2,390,513...2,414,882 		JBrowse link
G Pafah1b3 platelet activating factor acetylhydrolase 1b catalytic subunit 3 ISO RGD PMID:17330141 RGD:4107040 NCBI chrNW_004936706:212,635...215,498
Ensembl chrNW_004936706:212,096...215,497 		JBrowse link
G Reln reelin ISO RGD PMID:12670697 PMID:12764038 RGD:1358468 RGD:727518 NCBI chrNW_004936479:19,628,488...20,088,278
Ensembl chrNW_004936479:19,628,940...20,087,250 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:18237558 RGD:2325284 NCBI chrNW_004936561:3,826,802...3,844,406
Ensembl chrNW_004936561:3,825,787...3,844,483 		JBrowse link
G Vldlr very low density lipoprotein receptor ISO RGD PMID:12764038 RGD:1358468 NCBI chrNW_004936503:2,407,040...2,440,366
Ensembl chrNW_004936503:2,405,689...2,440,502 		JBrowse link
altered scatter factor/hepatocyte growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Met MET proto-oncogene, receptor tyrosine kinase ISO RGD PMID:19506583 PMID:20519133 PMID:20951313 PMID:21277552 RGD:5133241 RGD:5133242 RGD:5133243 RGD:5490965 NCBI chrNW_004936589:2,280,803...2,390,179
Ensembl chrNW_004936589:2,280,799...2,390,179 		JBrowse link
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad2 SMAD family member 2 ISO RGD PMID:17613544 PMID:18662538 RGD:2306282 RGD:2308865 NCBI chrNW_004936497:14,723,199...14,812,160
Ensembl chrNW_004936497:14,723,199...14,801,697 		JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:17613544 PMID:18772397 RGD:2306282 RGD:5490966 NCBI chrNW_004936471:27,080,662...27,185,861
Ensembl chrNW_004936471:27,080,575...27,189,793 		JBrowse link
G Smad4 SMAD family member 4 ISO RGD PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2306282 RGD:2308865 RGD:5490965 RGD:5490966 NCBI chrNW_004936497:12,242,869...12,278,012
Ensembl chrNW_004936497:12,249,140...12,278,123 		JBrowse link
G Smad7 SMAD family member 7 ISO RGD PMID:18662538 RGD:2308865 NCBI chrNW_004936497:13,894,586...13,921,978
Ensembl chrNW_004936497:13,894,580...13,922,065 		JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO RGD PMID:17613544 PMID:18313409 RGD:2299005 RGD:2306282 NCBI chrNW_004936661:3,742,080...3,758,266
Ensembl chrNW_004936661:3,742,066...3,758,272 		JBrowse link
G Tgfbr1 transforming growth factor beta receptor 1 ISO RGD PMID:17613544 PMID:18313409 RGD:2299005 RGD:2306282 NCBI chrNW_004936524:7,656,523...7,680,043
Ensembl chrNW_004936524:7,655,847...7,681,097 		JBrowse link
G Tgfbr2 transforming growth factor beta receptor 2 ISO RGD PMID:17613544 PMID:18313409 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2299005 RGD:2306282 RGD:2308865 RGD:5490965 RGD:5490966 NCBI chrNW_004936473:21,324,669...21,409,430
Ensembl chrNW_004936473:21,324,658...21,409,430 		JBrowse link
altered vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt4 fms related receptor tyrosine kinase 4 ISO RGD PMID:15563310 RGD:1334463 NCBI chrNW_004936739:240,572...281,925
Ensembl chrNW_004936739:236,510...281,729 		JBrowse link
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdr kinase insert domain receptor ISO RGD PMID:18221855 RGD:2292019 NCBI chrNW_004936482:17,537,697...17,581,320
Ensembl chrNW_004936482:17,538,864...17,581,002 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
altered vascular endothelial growth factor signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt4 fms related receptor tyrosine kinase 4 ISO RGD PMID:15563310 RGD:1334463 NCBI chrNW_004936739:240,572...281,925
Ensembl chrNW_004936739:236,510...281,729 		JBrowse link
G Kdr kinase insert domain receptor ISO RGD PMID:18221855 RGD:2292019 NCBI chrNW_004936482:17,537,697...17,581,320
Ensembl chrNW_004936482:17,538,864...17,581,002 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
altered visual phototransduction pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnga1 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:20212494 RGD:8547536 NCBI chrNW_004936482:14,091,343...14,107,793
Ensembl chrNW_004936482:14,091,913...14,107,787 		JBrowse link
G Cngb1 cyclic nucleotide gated channel subunit beta 1 ISO RGD PMID:20212494 RGD:8547536 NCBI chrNW_004936475:9,844,438...9,908,009 JBrowse link
G Guca1b guanylate cyclase activator 1B ISO RGD PMID:20212494 RGD:8547536 NCBI chrNW_004936476:17,679,505...17,688,970
Ensembl chrNW_004936476:17,679,500...17,691,037 		JBrowse link
G Pde6a phosphodiesterase 6A ISO RGD PMID:20212494 RGD:8547536 NCBI chrNW_004936504:5,018,171...5,088,333
Ensembl chrNW_004936504:5,018,064...5,092,024 		JBrowse link
G Pde6b phosphodiesterase 6B ISO RGD PMID:20212494 RGD:8547536 NCBI chrNW_004936477:22,418,037...22,472,251
Ensembl chrNW_004936477:22,417,453...22,472,185 		JBrowse link
G Pde6g phosphodiesterase 6G ISO RGD PMID:20212494 RGD:8547536 NCBI chrNW_004936594:5,263,345...5,267,240
Ensembl chrNW_004936594:5,263,333...5,267,476 		JBrowse link
G Rho rhodopsin ISO RGD PMID:20212494 RGD:8547536 NCBI chrNW_004936602:896,730...901,480
Ensembl chrNW_004936602:894,617...901,664 		JBrowse link
G Sag S-antigen visual arrestin ISO RGD PMID:20212494 RGD:8547536 NCBI chrNW_004936525:3,932,118...3,965,651
Ensembl chrNW_004936525:3,931,933...3,964,834 		JBrowse link
altered Wnt signaling, canonical pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO RGD PMID:18432252 RGD:2293188 NCBI chrNW_004936531:6,899,580...7,019,016
Ensembl chrNW_004936531:6,899,788...7,019,453 		JBrowse link
G Axin1 axin 1 ISO RGD PMID:18432252 RGD:2293188 NCBI chrNW_004936501:599,963...633,837
Ensembl chrNW_004936501:599,919...633,873 		JBrowse link
G Axin2 axin 2 ISO RGD PMID:18432252 RGD:2293188 NCBI chrNW_004936541:7,155,963...7,242,466
Ensembl chrNW_004936541:7,211,985...7,242,470 		JBrowse link
G Ctnnb1 catenin beta 1 ISO RGD PMID:18432252 PMID:19078924 RGD:2293188 RGD:4143515 NCBI chrNW_004936473:29,999,542...30,034,610
Ensembl chrNW_004936473:29,999,562...30,038,293 		JBrowse link
G Lrp5 LDL receptor related protein 5 ISO RGD PMID:18432252 RGD:2293188 NCBI chrNW_004936599:1,746,309...1,814,471
Ensembl chrNW_004936599:1,746,406...1,814,321 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO RGD PMID:20128690 RGD:150573713 NCBI chrNW_004936480:11,082,811...11,156,691
Ensembl chrNW_004936480:11,083,605...11,156,691 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO RGD PMID:18772397 RGD:5490966 NCBI chrNW_004936486:3,473,877...3,660,565
Ensembl chrNW_004936486:3,473,843...3,660,576 		JBrowse link
G Wnt9a Wnt family member 9A ISO RGD PMID:18772397 RGD:5490966 NCBI chrNW_004936864:216,381...245,885
Ensembl chrNW_004936864:239,651...244,312 		JBrowse link
Term paths to the root