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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:altered mitogen activated protein kinase pathway
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Accession:PW:0000421 term browser browse the term
Definition:A mitogen activated protein kinase pathway that deviates from what its normal course should be. Altered MAPK pathways have been linked to a spectrum of conditions.
Synonyms:related_synonym: altered MAPK signaling pathway


show annotations for term's descendants           Sort by:
altered Erk5 MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k5 mitogen activated protein kinase kinase 5 ISO RGD PMID:16376520 RGD:2298532 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO RGD PMID:16376520 RGD:2298532 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 PMID:21277552 PMID:20951313 PMID:18098337 RGD:2293882, RGD:5133243, RGD:5133242, RGD:2298531 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Kras KRAS proto-oncogene, GTPase TAS
ISO		 RGD PMID:16112461 PMID:19078924 PMID:20951313 PMID:19506583 PMID:18772397 RGD:2306732, RGD:4143515, RGD:5133242, RGD:5490965, RGD:5490966 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO RGD PMID:20951313 PMID:21277552 RGD:5133242, RGD:5133243 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 RGD:2293882 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      mitogen activated protein kinase signaling pathway 299
        altered mitogen activated protein kinase pathway 6
          altered Erk5 MAPK signaling pathway 2
          altered extracellular signal-regulated Raf/Mek/Erk signaling pathway 4
          altered stress-regulated MAPK signaling pathway + 0
Path 2
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      altered signaling pathway 116
        altered kinase mediated signaling pathway 13
          altered serine/threonine-specific kinase mediated signaling pathway 11
            altered mitogen activated protein kinase pathway 6
              altered Erk5 MAPK signaling pathway 2
              altered extracellular signal-regulated Raf/Mek/Erk signaling pathway 4
              altered stress-regulated MAPK signaling pathway + 0
paths to the root