Itgb1 (integrin subunit beta 1) - Rat Genome Database

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Pathways
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Gene: Itgb1 (integrin subunit beta 1) Ictidomys tridecemlineatus
Analyze
Symbol: Itgb1
Name: integrin subunit beta 1
RGD ID: 12728486
Description: ENCODES a protein that exhibits actin binding (ortholog); alpha-actinin binding (ortholog); C-X3-C chemokine binding (ortholog); INVOLVED IN axon extension (ortholog); bicellular tight junction assembly (ortholog); calcium-independent cell-matrix adhesion (ortholog); PARTICIPATES IN altered Reelin signaling pathway; glomerulonephritis pathway; integrin mediated signaling pathway; ASSOCIATED WITH calcinosis (ortholog); cardiomyopathy (ortholog); congestive heart failure (ortholog); FOUND IN acrosomal vesicle (ortholog); adherens junction (ortholog); basement membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: integrin beta-1; integrin subunit beta 1, transcript variant X1; integrin subunit beta 1, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934411,966,401 - 11,996,275 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365741,465,897 - 1,495,762 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365741,465,981 - 1,495,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
axon extension  (IEA,ISO)
basement membrane organization  (IEA)
bicellular tight junction assembly  (ISO)
calcium-independent cell-matrix adhesion  (IEA,ISO)
cardiac cell fate specification  (IEA,ISO)
cardiac muscle cell differentiation  (IEA,ISO)
cardiac muscle cell myoblast differentiation  (IEA,ISO)
CD40 signaling pathway  (IEA)
cell adhesion  (IEA)
cell adhesion mediated by integrin  (IEA)
cell migration  (IEA)
cell migration involved in sprouting angiogenesis  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell projection organization  (ISO)
cell-cell adhesion  (IEA)
cell-cell adhesion mediated by integrin  (IEA)
cell-matrix adhesion  (IEA,ISO)
cell-substrate adhesion  (IEA)
cellular response to ionizing radiation  (ISO)
cellular response to low-density lipoprotein particle stimulus  (IEA)
cellular response to mechanical stimulus  (ISO)
cellular response to vitamin D  (ISO)
dendrite morphogenesis  (IEA,ISO)
establishment of mitotic spindle orientation  (IEA)
establishment of Sertoli cell barrier  (ISO)
formation of radial glial scaffolds  (IEA,ISO)
G1/S transition of mitotic cell cycle  (IEA,ISO)
germ cell migration  (IEA,ISO)
heterotypic cell-cell adhesion  (IEA)
in utero embryonic development  (IEA,ISO)
integrin-mediated signaling pathway  (IEA)
lamellipodium assembly  (ISO)
leukocyte cell-cell adhesion  (IEA)
leukocyte tethering or rolling  (IEA)
maintenance of postsynaptic specialization structure  (ISO)
maternal process involved in female pregnancy  (ISO)
mesodermal cell differentiation  (IEA)
modulation of chemical synaptic transmission  (IEA)
muscle organ development  (IEA)
myoblast fate specification  (IEA,ISO)
negative regulation of anoikis  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell projection organization  (ISO)
negative regulation of neuron differentiation  (IEA,ISO)
negative regulation of Rho protein signal transduction  (IEA,ISO)
negative regulation of vasoconstriction  (IEA)
neuroblast proliferation  (IEA,ISO)
neuron differentiation  (IEA,ISO)
neuron projection development  (IEA,ISO)
phagocytosis  (ISO)
positive regulation of angiogenesis  (IEA)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of fibroblast growth factor receptor signaling pathway  (IEA)
positive regulation of fibroblast migration  (IEA)
positive regulation of glutamate uptake involved in transmission of nerve impulse  (IEA,ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of neuroblast proliferation  (IEA,ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of protein localization to plasma membrane  (IEA)
positive regulation of vascular endothelial growth factor signaling pathway  (IEA)
positive regulation of wound healing  (IEA)
protein transport within lipid bilayer  (ISO)
reactive gliosis  (IEA,ISO)
receptor internalization  (IEA)
regulation of cell cycle  (IEA,ISO)
regulation of collagen catabolic process  (IEA)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of inward rectifier potassium channel activity  (ISO)
regulation of postsynaptic neurotransmitter receptor diffusion trapping  (ISO)
regulation of spontaneous synaptic transmission  (IEA,ISO)
regulation of synapse pruning  (IEA)
response to activity  (ISO)
response to gonadotropin  (ISO)
response to muscle activity  (IEA)
response to nutrient levels  (ISO)
response to transforming growth factor beta  (ISO)
response to xenobiotic stimulus  (ISO)
sarcomere organization  (IEA,ISO)
stress fiber assembly  (ISO)
tissue homeostasis  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
visual learning  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Itgb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934411,966,401 - 11,996,275 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365741,465,897 - 1,495,762 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365741,465,981 - 1,495,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381032,900,318 - 32,958,230 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1032,887,273 - 33,005,792 (-)EnsemblGRCh38hg38GRCh38
GRCh371033,189,246 - 33,247,158 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361033,229,326 - 33,287,204 (-)NCBINCBI36Build 36hg18NCBI36
Build 341033,236,244 - 33,264,492NCBI
Celera1032,954,580 - 33,012,639 (-)NCBICelera
Cytogenetic Map10p11.22NCBI
HuRef1032,908,756 - 32,966,834 (-)NCBIHuRef
CHM1_11033,190,855 - 33,248,907 (-)NCBICHM1_1
T2T-CHM13v2.01032,929,042 - 32,986,969 (-)NCBIT2T-CHM13v2.0
Itgb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398129,412,135 - 129,460,060 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8129,412,135 - 129,459,681 (+)EnsemblGRCm39 Ensembl
GRCm388128,685,654 - 128,733,579 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8128,685,654 - 128,733,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv378131,209,554 - 131,257,479 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368131,571,871 - 131,619,287 (+)NCBIMGSCv36mm8
Celera8133,002,434 - 133,050,263 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map876.09NCBI
Itgb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81973,602,277 - 73,650,271 (+)NCBIGRCr8
mRatBN7.21956,705,123 - 56,753,199 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1956,705,171 - 56,753,195 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1963,495,092 - 63,543,090 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01964,355,011 - 64,403,009 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01966,437,682 - 66,485,679 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01961,677,512 - 61,725,537 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1961,677,542 - 61,725,535 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01972,324,582 - 72,372,325 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41958,600,095 - 58,647,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11958,605,791 - 58,652,463 (-)NCBI
Celera1956,037,604 - 56,085,651 (+)NCBICelera
Cytogenetic Map19q12NCBI
Itgb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554624,454,809 - 4,484,842 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554624,454,809 - 4,483,227 (+)NCBIChiLan1.0ChiLan1.0
ITGB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2845,544,239 - 45,602,146 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11045,549,559 - 45,607,471 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01033,023,573 - 33,081,384 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11033,608,978 - 33,662,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1033,608,978 - 33,644,031 (-)Ensemblpanpan1.1panPan2
ITGB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.123,728,472 - 3,757,696 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl23,670,596 - 3,756,961 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha23,811,003 - 3,857,059 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.024,006,817 - 4,053,107 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl24,006,751 - 4,081,502 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.123,785,306 - 3,831,383 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.023,819,236 - 3,865,356 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.023,939,078 - 3,985,170 (+)NCBIUU_Cfam_GSD_1.0
ITGB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1056,078,396 - 56,173,326 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11056,078,393 - 56,130,608 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21061,450,695 - 61,502,941 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1932,201,030 - 32,258,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl932,202,204 - 32,258,154 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605641,260,215 - 41,317,418 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248058,765,949 - 8,802,149 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248058,748,848 - 8,800,259 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000013463   ⟹   ENSSTOP00000012063
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365741,465,897 - 1,495,762 (-)Ensembl
RefSeq Acc Id: XM_005330822   ⟹   XP_005330879
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934411,966,401 - 11,996,275 (-)NCBI
SpeTri2.0NW_0049365741,465,982 - 1,495,714 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005330823   ⟹   XP_005330880
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934411,966,401 - 11,996,275 (-)NCBI
SpeTri2.0NW_0049365741,465,981 - 1,495,717 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005330879 (Get FASTA)   NCBI Sequence Viewer  
  XP_005330880 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000012063.2
GenBank Protein KAG3257477 (Get FASTA)   NCBI Sequence Viewer  
  KAG3257478 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005330880   ⟸   XM_005330823
- Peptide Label: isoform X2
- UniProtKB: I3ML23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005330879   ⟸   XM_005330822
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSSTOP00000012063   ⟸   ENSSTOT00000013463
Protein Domains
Integrin beta subunit cytoplasmic   Integrin beta subunit tail   Integrin beta subunit VWA   PSI


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000013459 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000013463.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
  4.10.1240.30 UniProtKB/TrEMBL
  Cytochrome c1, transmembrane anchor, C-terminal UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  ligand-binding face of the semaphorins, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
InterPro EGF_extracell UniProtKB/TrEMBL
  I-EGF_1 UniProtKB/TrEMBL
  Integrin_beta_N UniProtKB/TrEMBL
  Integrin_bsu UniProtKB/TrEMBL
  Integrin_bsu_cyt_dom UniProtKB/TrEMBL
  Integrin_bsu_tail UniProtKB/TrEMBL
  Integrin_bsu_tail_dom_sf UniProtKB/TrEMBL
  Integrin_bsu_VWA UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene Itgb1 ENTREZGENE
PANTHER PTHR10082 UniProtKB/TrEMBL
  PTHR10082:SF28 UniProtKB/TrEMBL
Pfam EGF_2 UniProtKB/TrEMBL
  I-EGF_1 UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/TrEMBL
  Integrin_beta UniProtKB/TrEMBL
  PSI_integrin UniProtKB/TrEMBL
PIRSF Integrin_B UniProtKB/TrEMBL
PRINTS INTEGRINB UniProtKB/TrEMBL
PROSITE INTEGRIN_BETA UniProtKB/TrEMBL
SMART INB UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Plexin repeat UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
  SSF69687 UniProtKB/TrEMBL
UniProt I3ML23 ENTREZGENE, UniProtKB/TrEMBL