Numb (NUMB endocytic adaptor protein) - Rat Genome Database

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Gene: Numb (NUMB endocytic adaptor protein) Ictidomys tridecemlineatus
Analyze
Symbol: Numb
Name: NUMB endocytic adaptor protein
RGD ID: 12696134
Description: ENCODES a protein that exhibits alpha-catenin binding (ortholog); beta-catenin binding (ortholog); cadherin binding (ortholog); INVOLVED IN adherens junction organization (ortholog); axonogenesis (ortholog); forebrain development (ortholog); PARTICIPATES IN altered Notch signaling pathway; altered Notch signaling pathway involving the macromolecules modifying the main players; Notch signaling pathway; ASSOCIATED WITH intellectual disability (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: NUMB, endocytic adaptor protein, transcript variant X1; NUMB, endocytic adaptor protein, transcript variant X10; NUMB, endocytic adaptor protein, transcript variant X2; NUMB, endocytic adaptor protein, transcript variant X3; NUMB, endocytic adaptor protein, transcript variant X4; NUMB, endocytic adaptor protein, transcript variant X5; NUMB, endocytic adaptor protein, transcript variant X6; NUMB, endocytic adaptor protein, transcript variant X7; NUMB, endocytic adaptor protein, transcript variant X8; NUMB, endocytic adaptor protein, transcript variant X9; protein numb homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864029,325,965 - 29,488,760 (+)NCBI
SpeTri2.0NW_0049364882,579,017 - 2,742,961 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

Genomics

Comparative Map Data
Numb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864029,325,965 - 29,488,760 (+)NCBI
SpeTri2.0NW_0049364882,579,017 - 2,742,961 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUMB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1473,275,107 - 73,458,617 (-)EnsemblGRCh38hg38GRCh38
GRCh381473,275,216 - 73,458,546 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371473,741,924 - 73,925,252 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361472,811,671 - 72,995,039 (-)NCBINCBI36hg18NCBI36
Build 341472,811,670 - 72,995,039NCBI
Celera1453,805,138 - 53,989,581 (-)NCBI
Cytogenetic Map14q24.2-q24.3NCBI
HuRef1453,907,407 - 54,092,058 (-)NCBIHuRef
CHM1_11473,681,206 - 73,864,710 (-)NCBICHM1_1
Numb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391283,840,808 - 83,968,713 (-)NCBIGRCm39mm39
GRCm39 Ensembl1283,840,808 - 83,968,708 (-)Ensembl
GRCm381283,794,034 - 83,921,942 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1283,794,034 - 83,921,934 (-)EnsemblGRCm38mm10GRCm38
MGSCv371285,136,389 - 85,183,293 (-)NCBIGRCm37mm9NCBIm37
MGSCv361284,685,187 - 84,732,091 (-)NCBImm8
Celera1285,241,999 - 85,288,880 (-)NCBICelera
Cytogenetic Map12D1NCBI
Numb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26103,431,400 - 103,553,422 (-)NCBI
Rnor_6.0 Ensembl6107,279,920 - 107,325,345 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06107,279,917 - 107,325,345 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06118,218,526 - 118,262,951 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46107,838,216 - 107,882,302 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16107,842,337 - 107,845,590 (-)NCBI
Celera6101,261,488 - 101,306,906 (-)NCBICelera
Cytogenetic Map6q24NCBI
Numb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555232,025,652 - 2,076,037 (+)NCBIChiLan1.0ChiLan1.0
NUMB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11472,714,555 - 72,905,062 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1472,714,555 - 72,798,037 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01453,854,280 - 54,046,410 (-)NCBIMhudiblu_PPA_v0panPan3
NUMB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1846,620,444 - 46,781,564 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl846,607,556 - 46,782,175 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha846,305,647 - 46,465,562 (-)NCBI
ROS_Cfam_1.0846,848,975 - 47,010,155 (-)NCBI
UMICH_Zoey_3.1846,516,801 - 46,677,888 (-)NCBI
UNSW_CanFamBas_1.0846,532,509 - 46,695,082 (-)NCBI
UU_Cfam_GSD_1.0846,923,765 - 47,086,380 (-)NCBI
NUMB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl796,624,260 - 96,799,975 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1796,624,270 - 96,798,690 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27102,419,471 - 102,504,648 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUMB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12450,528,839 - 50,718,288 (-)NCBI
ChlSab1.1 Ensembl2450,530,266 - 50,605,942 (-)Ensembl
Vero_WHO_p1.0NW_02366605338,714,520 - 38,899,034 (-)NCBI
Numb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473427,994,662 - 28,144,719 (+)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005321205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013356840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021723742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021723744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021723745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021723746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021723747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021723748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021723749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021723750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040275547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040275548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040275549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040275550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040275551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040275552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010003700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005321205   ⟹   XP_005321262
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864029,325,965 - 29,488,760 (+)NCBI
SpeTri2.0NW_0049364882,579,017 - 2,742,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013356840   ⟹   XP_013212294
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049364882,579,019 - 2,742,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723742   ⟹   XP_021579417
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864029,326,004 - 29,488,760 (+)NCBI
SpeTri2.0NW_0049364882,579,017 - 2,742,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723744   ⟹   XP_021579419
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864029,325,982 - 29,488,760 (+)NCBI
SpeTri2.0NW_0049364882,579,017 - 2,742,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723745   ⟹   XP_021579420
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864029,326,003 - 29,488,760 (+)NCBI
SpeTri2.0NW_0049364882,579,017 - 2,742,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723746   ⟹   XP_021579421
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049364882,579,017 - 2,742,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723747   ⟹   XP_021579422
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049364882,579,017 - 2,742,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723748   ⟹   XP_021579423
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049364882,579,017 - 2,742,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723749   ⟹   XP_021579424
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049364882,579,018 - 2,742,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723750   ⟹   XP_021579425
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049364882,579,019 - 2,742,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040275547   ⟹   XP_040131481
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864029,326,266 - 29,488,760 (+)NCBI
RefSeq Acc Id: XM_040275548   ⟹   XP_040131482
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864029,325,965 - 29,488,760 (+)NCBI
RefSeq Acc Id: XM_040275549   ⟹   XP_040131483
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864029,325,966 - 29,488,760 (+)NCBI
RefSeq Acc Id: XM_040275550   ⟹   XP_040131484
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864029,325,966 - 29,488,760 (+)NCBI
RefSeq Acc Id: XM_040275551   ⟹   XP_040131485
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864029,325,966 - 29,488,760 (+)NCBI
RefSeq Acc Id: XM_040275552   ⟹   XP_040131486
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864029,325,967 - 29,488,760 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005321262   ⟸   XM_005321205
- Peptide Label: isoform X1
- UniProtKB: A0A287DCQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013212294   ⟸   XM_013356840
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_021579423   ⟸   XM_021723748
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_021579419   ⟸   XM_021723744
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021579420   ⟸   XM_021723745
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021579422   ⟸   XM_021723747
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_021579421   ⟸   XM_021723746
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021579417   ⟸   XM_021723742
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021579424   ⟸   XM_021723749
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_021579425   ⟸   XM_021723750
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_040131482   ⟸   XM_040275548
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040131485   ⟸   XM_040275551
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040131483   ⟸   XM_040275549
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040131484   ⟸   XM_040275550
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040131486   ⟸   XM_040275552
- Peptide Label: isoform X6
RefSeq Acc Id: XP_040131481   ⟸   XM_040275547
- Peptide Label: isoform X1
Protein Domains
PID


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003900 ENTREZGENE
Ensembl Protein ENSSTOP00000031271 ENTREZGENE
NCBI Gene Numb ENTREZGENE
UniProt A0A287DCQ6 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 Numb  NUMB endocytic adaptor protein    NUMB, endocytic adaptor protein  Symbol and/or name change 5135510 APPROVED