Smad2 (SMAD family member 2) - Rat Genome Database

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Gene: Smad2 (SMAD family member 2) Ictidomys tridecemlineatus
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Symbol: Smad2
Name: SMAD family member 2
RGD ID: 12478367
Description: ENCODES a protein that exhibits chromatin binding (ortholog); co-SMAD binding (ortholog); disordered domain specific binding (ortholog); INVOLVED IN activin receptor signaling pathway (ortholog); adrenal gland development (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN activin signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; ASSOCIATED WITH acromicric dysplasia (ortholog); breast carcinoma (ortholog); cervical cancer (ortholog); FOUND IN activin responsive factor complex (ortholog); chromatin (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: mothers against decapentaplegic homolog 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494439,484,164 - 39,562,655 (+)NCBI
SpeTri2.0NW_00493649714,723,199 - 14,812,160 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (ISO)
adrenal gland development  (ISO)
anterior/posterior pattern specification  (ISO)
cell fate commitment  (ISO)
common-partner SMAD protein phosphorylation  (ISO)
developmental growth  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic foregut morphogenesis  (ISO)
embryonic pattern specification  (ISO)
endoderm development  (ISO)
endoderm formation  (ISO)
gastrulation  (ISO)
heart development  (ISO)
in utero embryonic development  (ISO)
insulin secretion  (ISO)
intracellular signal transduction  (ISO)
lung development  (ISO)
mesoderm formation  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
nodal signaling pathway  (ISO)
organ growth  (ISO)
pancreas development  (ISO)
paraxial mesoderm morphogenesis  (ISO)
pattern specification process  (ISO)
pericardium development  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
post-embryonic development  (ISO)
protein phosphorylation  (ISO)
regulation of binding  (ISO)
regulation of transforming growth factor beta receptor signaling pathway  (ISO)
response to cholesterol  (ISO)
response to glucose  (ISO)
secondary palate development  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
SMAD protein complex assembly  (ISO)
SMAD protein signal transduction  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
ureteric bud development  (ISO)
wound healing  (ISO)
zygotic specification of dorsal/ventral axis  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
Smad2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494439,484,164 - 39,562,655 (+)NCBI
SpeTri2.0NW_00493649714,723,199 - 14,812,160 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1847,808,957 - 47,931,146 (-)EnsemblGRCh38hg38GRCh38
GRCh381847,808,957 - 47,931,188 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371845,335,328 - 45,457,243 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361843,613,464 - 43,711,510 (-)NCBINCBI36hg18NCBI36
Build 341843,618,434 - 43,710,924NCBI
Celera1842,208,816 - 42,306,655 (-)NCBI
Cytogenetic Map18q21.1NCBI
HuRef1842,208,822 - 42,306,925 (-)NCBIHuRef
CHM1_11845,354,416 - 45,452,506 (-)NCBICHM1_1
Smad2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391876,369,898 - 76,444,819 (+)NCBIGRCm39mm39
GRCm39 Ensembl1876,374,651 - 76,444,034 (+)Ensembl
GRCm381876,241,090 - 76,311,748 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1876,241,580 - 76,310,963 (+)EnsemblGRCm38mm10GRCm38
MGSCv371876,401,579 - 76,465,385 (+)NCBIGRCm37mm9NCBIm37
MGSCv361876,367,290 - 76,431,096 (+)NCBImm8
Celera1877,499,761 - 77,546,271 (+)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1851.42NCBI
Smad2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21869,849,884 - 69,918,926 (+)NCBI
Rnor_6.0 Ensembl1872,550,219 - 72,612,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01872,550,107 - 72,612,078 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01871,672,879 - 71,735,128 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41873,180,520 - 73,241,707 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11873,253,792 - 73,314,980 (+)NCBI
Celera1868,381,756 - 68,443,610 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
Smad2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540233,136,778 - 33,216,844 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540233,131,760 - 33,217,144 (-)NCBIChiLan1.0ChiLan1.0
SMAD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11844,572,213 - 44,669,008 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1844,580,905 - 44,668,530 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01841,213,001 - 41,309,902 (-)NCBIMhudiblu_PPA_v0panPan3
SMAD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1743,696,883 - 43,778,063 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl743,700,445 - 43,769,983 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha743,181,631 - 43,262,778 (+)NCBI
ROS_Cfam_1.0743,649,238 - 43,731,066 (+)NCBI
UMICH_Zoey_3.1743,350,952 - 43,432,066 (+)NCBI
UNSW_CanFamBas_1.0743,405,083 - 43,486,241 (+)NCBI
UU_Cfam_GSD_1.0743,688,637 - 43,769,813 (+)NCBI
SMAD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl197,415,716 - 97,511,358 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1197,415,360 - 97,511,388 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21106,898,131 - 106,991,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11833,017,138 - 33,105,320 (+)NCBI
ChlSab1.1 Ensembl1833,017,492 - 33,104,606 (+)Ensembl
Smad2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477811,380,656 - 11,460,566 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005323082   ⟹   XP_005323139
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494439,484,164 - 39,562,655 (+)NCBI
SpeTri2.0NW_00493649714,723,199 - 14,812,160 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021725027   ⟹   XP_021580702
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494439,484,164 - 39,562,655 (+)NCBI
SpeTri2.0NW_00493649714,723,221 - 14,812,160 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021725028   ⟹   XP_021580703
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494439,484,164 - 39,562,655 (+)NCBI
SpeTri2.0NW_00493649714,723,221 - 14,812,160 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021725029   ⟹   XP_021580704
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494439,484,164 - 39,562,650 (+)NCBI
SpeTri2.0NW_00493649714,723,220 - 14,812,160 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005323139 (Get FASTA)   NCBI Sequence Viewer  
  XP_021580702 (Get FASTA)   NCBI Sequence Viewer  
  XP_021580703 (Get FASTA)   NCBI Sequence Viewer  
  XP_021580704 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005323139   ⟸   XM_005323082
- Peptide Label: isoform X1
- UniProtKB: I3M2Z7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021580704   ⟸   XM_021725029
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021580702   ⟸   XM_021725027
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021580703   ⟸   XM_021725028
- Peptide Label: isoform X1
- Sequence:
Protein Domains
MH1   MH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003788 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000003397 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003791 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.10 UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/TrEMBL
NCBI Gene Smad2 ENTREZGENE
PANTHER PTHR13703 UniProtKB/TrEMBL
Pfam MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
PROSITE MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
SMART DWA UniProtKB/TrEMBL
  DWB UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/TrEMBL
  SSF56366 UniProtKB/TrEMBL
UniProt I3M2Z7 ENTREZGENE, UniProtKB/TrEMBL