Shh (sonic hedgehog signaling molecule)

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Gene: Shh (sonic hedgehog signaling molecule) Ictidomys tridecemlineatus

Analyze

Symbol:

Shh

Name:

sonic hedgehog signaling molecule

RGD ID:

12598175

Description:

ENCODES a protein that exhibits hydrolase activity (ortholog); INVOLVED IN alpha-beta T cell differentiation (ortholog); anatomical structure development (ortholog); anatomical structure formation involved in morphogenesis (ortholog); PARTICIPATES IN altered Hedgehog signaling pathway; forkhead class A signaling pathway; glypican signaling pathway; ASSOCIATED WITH acrocallosal syndrome (ortholog); Anorectal Malformations (ortholog); atrioventricular septal defect (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); endoplasmic reticulum (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

sonic hedgehog

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	2,860,455 - 2,871,247 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	10,033,299 - 10,042,599 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936527	10,033,095 - 10,042,713 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acrocallosal syndrome (ISO)

Anorectal Malformations (ISO)

atrioventricular septal defect (ISO)

autism spectrum disorder (ISO)

autistic disorder (ISO)

basal cell carcinoma (ISO)

biliary atresia (ISO)

brachydactyly type A1 (ISO)

chronic kidney disease (ISO)

cleft palate (ISO)

colorectal cancer (ISO)

Congenital Limb Deformities (ISO)

demyelinating disease (ISO)

esophageal atresia/tracheoesophageal fistula (ISO)

Experimental Arthritis (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Eye Abnormalities (ISO)

Facial Dysmorphism with Multiple Malformations (ISO)

Failure to Thrive (ISO)

Fluoride Poisoning (ISO)

focal segmental glomerulosclerosis (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Hirschsprung's disease (ISO)

holoprosencephaly (ISO)

holoprosencephaly 3 (ISO)

Hyperoxic Lung Injury (ISO)

hypoplastic or aplastic tibia with polydactyly (ISO)

hypothyroidism (ISO)

IgA glomerulonephritis (ISO)

Isolated Microphthalmia with Coloboma 5 (ISO)

Kidney Reperfusion Injury (ISO)

membranous glomerulonephritis (ISO)

microphthalmia (ISO)

middle cerebral artery infarction (ISO)

multiple sclerosis (ISO)

myocardial infarction (ISO)

Myocardial Reperfusion Injury (ISO)

Neurodevelopmental Disorder with Dysmorphic Facies and Distal Limb Anomalies (ISO)

nevoid basal cell carcinoma syndrome (ISO)

ocular hypertension (ISO)

Parkinsonism (ISO)

Partial Agenesis of Corpus Callosum (ISO)

Patterson Stevenson Syndrome (ISO)

Peripheral Nerve Injuries (ISO)

Persistent Cloaca (ISO)

polydactyly (ISO)

pre-malignant neoplasm (ISO)

Preaxial Polydactyly II (ISO)

primary progressive multiple sclerosis (ISO)

Schizencephaly (ISO)

secondary Parkinson disease (ISO)

septooptic dysplasia (ISO)

solitary median maxillary central incisor (ISO)

Spinal Cord Injuries (ISO)

stomach cancer (ISO)

Subarachnoid Hemorrhage (ISO)

syndactyly type 4 (ISO)

temporal lobe epilepsy (ISO)

ureteral obstruction (ISO)

VACTERL association (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

alpha-beta T cell differentiation (IEA,ISO)

alpha-tubulin acetylation (IEA)

anatomical structure development (IEA,ISO)

anatomical structure formation involved in morphogenesis (IEA,ISO)

androgen metabolic process (IEA,ISO)

angiogenesis (IEA,ISO)

animal organ development (IEA)

animal organ formation (IEA,ISO)

anterior/posterior pattern specification (IEA,ISO)

apoptotic signaling pathway (IEA)

artery development (IEA,ISO)

astrocyte differentiation (IEA,ISO)

axon guidance (IEA,ISO)

Bergmann glial cell differentiation (IEA,ISO)

blood coagulation (IEA,ISO)

branching involved in blood vessel morphogenesis (IEA,ISO)

branching involved in prostate gland morphogenesis (IEA,ISO)

branching involved in salivary gland morphogenesis (IEA,ISO)

branching involved in ureteric bud morphogenesis (IEA,ISO)

branching morphogenesis of an epithelial tube (IEA,ISO)

bud outgrowth involved in lung branching (IEA,ISO)

camera-type eye development (IEA,ISO)

canonical Wnt signaling pathway (IEA,ISO)

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (IEA)

cell development (IEA,ISO)

cell fate commitment (IEA,ISO)

cell fate specification (IEA,ISO)

cell migration (IEA,ISO)

cell population proliferation (IEA,ISO)

cell proliferation in external granule layer (IEA,ISO)

cell-cell signaling (IEA,ISO)

cellular response to lithium ion (IEA,ISO)

central nervous system development (IEA,ISO)

cerebellar granule cell precursor proliferation (IEA,ISO)

commissural neuron axon guidance (ISO)

determination of left/right asymmetry in lateral mesoderm (IEA)

determination of left/right symmetry (IEA,ISO)

developmental growth (IEA,ISO)

digestive tract mesoderm development (ISO)

digestive tract morphogenesis (IEA,ISO)

dorsal/ventral neural tube patterning (IEA,ISO)

dorsal/ventral pattern formation (IEA,ISO)

ectoderm development (IEA,ISO)

embryonic digestive tract morphogenesis (IEA,ISO)

embryonic digit morphogenesis (IEA,ISO)

embryonic foregut morphogenesis (IEA,ISO)

embryonic forelimb morphogenesis (IEA,ISO)

embryonic hindlimb morphogenesis (IEA,ISO)

embryonic limb morphogenesis (IEA,ISO)

embryonic morphogenesis (IEA,ISO)

embryonic organ development (IEA,ISO)

embryonic skeletal system development (IEA,ISO)

endocytosis (IEA,ISO)

epithelial cell proliferation (IEA,ISO)

epithelial cell proliferation involved in prostate gland development (IEA,ISO)

epithelial cell proliferation involved in salivary gland morphogenesis (IEA,ISO)

epithelial tube branching involved in lung morphogenesis (IEA,ISO)

epithelial-mesenchymal cell signaling (IEA,ISO)

epithelial-mesenchymal signaling involved in prostate gland development (IEA,ISO)

establishment of epithelial cell polarity (IEA,ISO)

forebrain development (IEA,ISO)

forebrain regionalization (IEA,ISO)

formation of anatomical boundary (IEA,ISO)

fungiform papilla development (ISO)

fungiform papilla formation (ISO)

fungiform papilla morphogenesis (ISO)

gene expression (IEA,ISO)

hair follicle development (IEA,ISO)

hair follicle morphogenesis (IEA,ISO)

heart development (IEA,ISO)

heart looping (IEA,ISO)

hindbrain development (IEA,ISO)

hindgut morphogenesis (IEA,ISO)

inner ear development (IEA,ISO)

intein-mediated protein splicing (IEA)

intermediate filament organization (IEA,ISO)

kidney development (IEA,ISO)

left lung development (IEA,ISO)

limb bud formation (IEA,ISO)

limb development (IEA,ISO)

liver regeneration (ISO)

lung development (IEA,ISO)

lung epithelium development (IEA,ISO)

lung lobe morphogenesis (IEA,ISO)

lung morphogenesis (IEA,ISO)

lung-associated mesenchyme development (IEA,ISO)

lymphoid progenitor cell differentiation (IEA)

male genitalia development (IEA,ISO)

male genitalia morphogenesis (ISO)

mesenchymal cell apoptotic process (IEA,ISO)

mesenchymal cell proliferation (IEA,ISO)

mesenchymal cell proliferation involved in lung development (IEA,ISO)

mesenchymal smoothened signaling pathway involved in prostate gland development (IEA,ISO)

metanephric collecting duct development (IEA)

metanephric mesenchymal cell proliferation involved in metanephros development (IEA)

metanephros development (IEA)

midbrain development (IEA,ISO)

myoblast differentiation (IEA,ISO)

myotube differentiation (IEA,ISO)

negative regulation of alpha-beta T cell differentiation (IEA,ISO)

negative regulation of apoptotic process (IEA,ISO)

negative regulation of canonical Wnt signaling pathway (IEA,ISO)

negative regulation of cell migration (IEA,ISO)

negative regulation of cholesterol efflux (IEA)

negative regulation of dopaminergic neuron differentiation (IEA)

negative regulation of gene expression (IEA)

negative regulation of kidney smooth muscle cell differentiation (IEA)

negative regulation of mesenchymal cell apoptotic process (IEA,ISO)

negative regulation of neuron death (ISO)

negative regulation of neuron differentiation (IEA,ISO)

negative regulation of proteasomal ubiquitin-dependent protein catabolic process (IEA,ISO)

negative regulation of protein binding (IEA,ISO)

negative regulation of protein catabolic process (IEA,ISO)

negative regulation of T cell differentiation in thymus (IEA,ISO)

negative regulation of T cell proliferation (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

negative regulation of transcription elongation by RNA polymerase II (IEA,ISO)

negative regulation of ureter smooth muscle cell differentiation (IEA)

negative regulation of Wnt signaling pathway (IEA,ISO)

negative thymic T cell selection (IEA)

neural crest cell migration (IEA,ISO)

neural tube formation (ISO)

neuroblast proliferation (IEA,ISO)

neuron differentiation (IEA,ISO)

neuron fate commitment (IEA,ISO)

odontogenesis (IEA,ISO)

odontogenesis of dentin-containing tooth (IEA,ISO)

oligodendrocyte development (IEA,ISO)

oligodendrocyte differentiation (IEA,ISO)

osteoblast development (IEA,ISO)

pancreas development (IEA,ISO)

pattern specification process (IEA,ISO)

polarity specification of anterior/posterior axis (IEA)

positive regulation of alpha-beta T cell differentiation (IEA)

positive regulation of astrocyte differentiation (IEA,ISO)

positive regulation of cell division (IEA)

positive regulation of cell population proliferation (IEA,ISO)

positive regulation of cerebellar granule cell precursor proliferation (IEA,ISO)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of endothelial cell chemotaxis (ISO)

positive regulation of epithelial cell proliferation (IEA,ISO)

positive regulation of epithelial cell proliferation involved in prostate gland development (IEA,ISO)

positive regulation of gene expression (IEA,ISO)

positive regulation of hh target transcription factor activity (IEA,ISO)

positive regulation of immature T cell proliferation in thymus (IEA)

positive regulation of kidney smooth muscle cell differentiation (IEA)

positive regulation of mesenchymal cell proliferation (IEA,ISO)

positive regulation of mesenchymal cell proliferation involved in ureter development (IEA)

positive regulation of neuroblast proliferation (IEA,ISO)

positive regulation of neuron differentiation (ISO)

positive regulation of neurotrophin production (ISO)

positive regulation of oligodendrocyte differentiation (IEA,ISO)

positive regulation of oligodendrocyte progenitor proliferation (ISO)

positive regulation of penile erection (ISO)

positive regulation of photoreceptor cell differentiation (ISO)

positive regulation of protein import into nucleus (IEA,ISO)

positive regulation of sclerotome development (IEA)

positive regulation of skeletal muscle cell proliferation (IEA,ISO)

positive regulation of skeletal muscle tissue development (IEA,ISO)

positive regulation of smoothened signaling pathway (IEA)

positive regulation of sprouting angiogenesis (ISO)

positive regulation of striated muscle cell differentiation (IEA,ISO)

positive regulation of T cell differentiation in thymus (IEA)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of ureter smooth muscle cell differentiation (IEA)

positive regulation of Wnt signaling pathway (IEA,ISO)

positive thymic T cell selection (IEA)

primary prostatic bud elongation (IEA,ISO)

prostate epithelial cord elongation (IEA,ISO)

prostate gland development (IEA,ISO)

prostatic bud formation (ISO)

protein autoprocessing (IEA)

protein import into nucleus (IEA,ISO)

protein localization to nucleus (IEA,ISO)

proteolysis (IEA)

regulation of cell population proliferation (ISO)

regulation of DNA-templated transcription (IEA,ISO)

regulation of epithelial cell differentiation (ISO)

regulation of epithelial cell proliferation involved in prostate gland development (IEA,ISO)

regulation of gene expression (IEA,ISO)

regulation of glial cell proliferation (IEA,ISO)

regulation of mesenchymal cell proliferation involved in prostate gland development (IEA,ISO)

regulation of odontogenesis (IEA)

regulation of prostatic bud formation (IEA,ISO)

regulation of protein localization to nucleus (IEA)

regulation of proteolysis (IEA,ISO)

regulation of stem cell proliferation (IEA,ISO)

respiratory tube development (IEA,ISO)

response to axon injury (ISO)

response to estradiol (ISO)

response to ethanol (ISO)

response to hypoxia (ISO)

response to organonitrogen compound (ISO)

response to retinoic acid (ISO)

right lung development (IEA,ISO)

roof of mouth development (IEA,ISO)

salivary gland cavitation (IEA,ISO)

self proteolysis (IEA)

skeletal muscle cell proliferation (IEA,ISO)

skeletal muscle fiber differentiation (IEA,ISO)

skeletal muscle tissue development (IEA,ISO)

skin development (IEA,ISO)

smooth muscle tissue development (IEA)

smoothened signaling pathway (IEA,ISO)

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation (IEA,ISO)

somite development (IEA)

spinal cord dorsal/ventral patterning (IEA,ISO)

spinal cord motor neuron differentiation (IEA,ISO)

stem cell development (IEA)

stem cell proliferation (IEA,ISO)

striated muscle cell differentiation (IEA,ISO)

striated muscle tissue development (IEA,ISO)

system development (IEA)

T cell differentiation in thymus (IEA,ISO)

T cell proliferation (IEA,ISO)

telencephalon regionalization (IEA,ISO)

thalamus development (IEA,ISO)

thymus development (IEA)

thyroid gland development (IEA,ISO)

tongue development (ISO)

tongue morphogenesis (ISO)

trachea development (IEA,ISO)

trachea morphogenesis (IEA,ISO)

tracheoesophageal septum formation (IEA,ISO)

trunk neural crest cell migration (IEA,ISO)

vasculature development (IEA,ISO)

vasculogenesis (IEA,ISO)

ventral spinal cord interneuron specification (ISO)

zona limitans intrathalamica formation (ISO)

Cellular Component

axon (ISO)

cell surface (IEA)

dendrite (ISO)

endoplasmic reticulum (IEA)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (IEA)

extracellular matrix (IEA)

extracellular region (ISO)

extracellular space (IEA,ISO)

Golgi apparatus (IEA)

Golgi apparatus (ISO)

Golgi membrane (IEA)

membrane (IEA)

membrane raft (IEA)

membrane raft (ISO)

neuronal cell body (ISO)

nucleus (ISO)

plasma membrane (IEA)

synaptic vesicle (ISO)

transport vesicle (ISO)

Molecular Function

calcium ion binding (IEA)

cholesterol-protein transferase activity (IEA)

glycosaminoglycan binding (IEA)

hydrolase activity (IEA,ISO)

laminin-1 binding (IEA)

metal ion binding (IEA)

patched binding (IEA)

peptidase activity (IEA)

protein binding (ISO)

transferase activity (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

altered Hedgehog signaling pathway (ISO)

forkhead class A signaling pathway (ISO)

glypican signaling pathway (ISO)

Hedgehog signaling pathway (ISO)

pancreatic cancer pathway (ISO)

References

Genomics

Comparative Map Data

Shh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	2,860,455 - 2,871,247 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	10,033,299 - 10,042,599 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936527	10,033,095 - 10,042,713 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SHH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	155,799,980 - 155,812,463 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	7	155,799,980 - 155,812,463 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	155,592,674 - 155,605,157 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	155,288,319 - 155,297,728 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	155,095,033 - 155,104,443	NCBI
Celera	7	150,021,217 - 150,030,626 (-)	NCBI		Celera
Cytogenetic Map	7	q36.3	NCBI
HuRef	7	149,327,101 - 149,336,513 (-)	NCBI		HuRef
CHM1_1	7	155,604,000 - 155,613,409 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	156,983,127 - 156,995,607 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	154,827,119 - 154,836,528 (-)	NCBI

Shh
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	28,661,838 - 28,672,099 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	28,661,813 - 28,672,254 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	28,456,840 - 28,467,101 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	28,456,815 - 28,467,256 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	28,783,380 - 28,793,641 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	28,787,627 - 28,797,875 (-)	NCBI		MGSCv36	mm8
Celera	5	25,997,895 - 26,008,156 (-)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	14.39	NCBI

Shh
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	6,954,017 - 6,963,170 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	6,954,017 - 6,963,170 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	11,962,609 - 11,971,762 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	4	7,776,827 - 7,785,980 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	4	6,123,054 - 6,132,207 (+)	NCBI	Rnor_WKY
Rnor_6.0	4	718,538 - 727,691 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	718,538 - 727,691 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	711,420 - 720,573 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	2,200,504 - 2,209,657 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	2,200,503 - 2,209,657 (+)	NCBI
Celera	4	3,316,537 - 3,325,690 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

Shh
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955491	8,647,133 - 8,657,381 (-)	NCBI	ChiLan1.0	ChiLan1.0

SHH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	7	159,116,966 - 159,126,660 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	159,114,666 - 159,126,651 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	7	147,400,112 - 147,414,036 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

SHH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	18,650,553 - 18,663,571 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	18,484,809 - 18,662,903 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	19,286,449 - 19,295,913 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	20,382,879 - 20,392,367 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	20,382,707 - 20,392,037 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	18,753,210 - 18,762,671 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	19,333,131 - 19,342,583 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	19,386,812 - 19,396,258 (-)	NCBI		UU_Cfam_GSD_1.0

SHH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	2,545,994 - 2,555,484 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	2,546,202 - 2,555,484 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	2,664,794 - 2,673,805 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SHH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	123,929,937 - 123,942,451 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	123,932,900 - 123,942,395 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	20,134,625 - 20,147,164 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Shh
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624800	2,203,393 - 2,212,068 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624800	2,202,986 - 2,215,309 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005326733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040292011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSTOT00000027983 ⟹ ENSSTOP00000015201

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936527	10,033,299 - 10,042,599 (-)	Ensembl

RefSeq Acc Id:

XM_040292011 ⟹ XP_040147945

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	2,860,455 - 2,871,247 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_040147945	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	KAG3277154	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_040147945 ⟸ XM_040292011

RefSeq Acc Id:

ENSSTOP00000015201 ⟸ ENSSTOT00000027983

Protein Domains

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Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000021031	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSSTOP00000015201.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000027983.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1380.10	UniProtKB/TrEMBL
	Hedgehog/Intein (Hint) domain	UniProtKB/TrEMBL
InterPro	Hedgehog	UniProtKB/TrEMBL
	Hedgehog_Hint	UniProtKB/TrEMBL
	Hedgehog_sig/DD-Pept_Zn-bd_sf	UniProtKB/TrEMBL
	Hedgehog_signalling_dom	UniProtKB/TrEMBL
	Hint_dom_N	UniProtKB/TrEMBL
	Hint_dom_sf	UniProtKB/TrEMBL
	Intein_N	UniProtKB/TrEMBL
NCBI Gene	Shh	ENTREZGENE
PANTHER	HEDGEHOG	UniProtKB/TrEMBL
	SONIC HEDGEHOG PROTEIN	UniProtKB/TrEMBL
Pfam	HH_signal	UniProtKB/TrEMBL
	Hint	UniProtKB/TrEMBL
PIRSF	Peptidase_C46	UniProtKB/TrEMBL
PRINTS	SONICHHOG	UniProtKB/TrEMBL
PROSITE	INTEIN_N_TER	UniProtKB/TrEMBL
	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
SMART	HintN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51294	UniProtKB/TrEMBL
	SSF55166	UniProtKB/TrEMBL
UniProt	I3MSV6_ICTTR	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-11-29	Shh	sonic hedgehog signaling molecule		sonic hedgehog	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)