Tp63 (tumor protein p63) - Rat Genome Database

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Pathways
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Gene: Tp63 (tumor protein p63) Ictidomys tridecemlineatus
Analyze
Symbol: Tp63
Name: tumor protein p63
RGD ID: 12481462
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); animal organ morphogenesis (ortholog); cellular senescence (ortholog); PARTICIPATES IN altered p53 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); ADULT syndrome (ortholog); amenorrhea (ortholog); FOUND IN dendrite (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tumor protein 63; tumor protein p63, transcript variant X1; tumor protein p63, transcript variant X2; tumor protein p63, transcript variant X3; tumor protein p63, transcript variant X4; tumor protein p63, transcript variant X5; tumor protein p63, transcript variant X6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602114,397,903 - 114,613,831 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936578491,507 - 705,729 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936578492,267 - 705,282 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
ADULT syndrome  (ISO)
amenorrhea  (ISO)
Ankyloblepharon Filiforme Adnatum  (ISO)
ankyloblepharon-ectodermal defects-cleft lip/palate syndrome  (ISO)
Auditory Neuropathy  (ISO)
bladder exstrophy  (ISO)
bladder exstrophy-epispadias-cloacal exstrophy complex  (ISO)
breast disease  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cervix uteri carcinoma in situ  (ISO)
cleft lip  (ISO)
Cleft Lip with or without Cleft Palate, Nonsyndromic, 8  (ISO)
cleft palate  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Foot Deformities  (ISO)
Congenital Hand Deformities  (ISO)
Congenital Limb Deformities  (ISO)
Corneal Injuries  (ISO)
Craniofacial Abnormalities  (ISO)
ectodermal dysplasia  (ISO)
ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3  (ISO)
EEC syndrome  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Neoplasms  (ISO)
Female Urogenital Diseases  (ISO)
fissured tongue  (ISO)
gastroesophageal reflux disease  (ISO)
genetic disease  (ISO)
Limb-Mammary Syndrome  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
Multiple Abnormalities  (ISO)
muscular dystrophy  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
orofacial cleft 8  (ISO)
osteochondrodysplasia  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
primary ovarian insufficiency  (ISO)
Primary Ovarian Insufficiency 21  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
Rapp-Hodgkin syndrome  (ISO)
schizophrenia  (ISO)
Skin Abnormalities  (ISO)
split hand-foot malformation  (ISO)
split hand-foot malformation 4  (ISO)
squamous cell carcinoma  (ISO)
squamous cell neoplasm  (ISO)
Sweat Gland Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (IEA,ISO)
animal organ morphogenesis  (IEA,ISO)
apoptotic process  (IEA)
cellular senescence  (IEA,ISO)
chromatin remodeling  (IEA,ISO)
cloacal septation  (IEA,ISO)
cranial skeletal system development  (IEA,ISO)
determination of adult lifespan  (IEA,ISO)
DNA damage response  (ISO)
ectoderm and mesoderm interaction  (IEA,ISO)
embryonic forelimb morphogenesis  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA,ISO)
embryonic limb morphogenesis  (IEA,ISO)
epidermal cell differentiation  (IEA,ISO)
epidermal cell division  (IEA,ISO)
epidermis development  (IEA,ISO)
epithelial cell development  (IEA,ISO)
epithelial cell differentiation  (IEA,ISO)
establishment of planar polarity  (IEA,ISO)
establishment of skin barrier  (IEA)
female genitalia morphogenesis  (IEA,ISO)
hair follicle development  (IEA,ISO)
hair follicle morphogenesis  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
keratinocyte differentiation  (IEA,ISO)
keratinocyte proliferation  (IEA,ISO)
morphogenesis of a polarized epithelium  (IEA,ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of intracellular estrogen receptor signaling pathway  (IEA)
negative regulation of keratinocyte differentiation  (IEA,ISO)
negative regulation of mesoderm development  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
Notch signaling pathway  (IEA,ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
pattern specification process  (IEA,ISO)
polarized epithelial cell differentiation  (IEA,ISO)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of cell cycle G1/S phase transition  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of fibroblast apoptotic process  (IEA)
positive regulation of keratinocyte proliferation  (IEA,ISO)
positive regulation of Notch signaling pathway  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of somatic stem cell population maintenance  (IEA)
positive regulation of stem cell proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
post-anal tail morphogenesis  (IEA,ISO)
prostate gland development  (IEA,ISO)
prostatic bud formation  (IEA,ISO)
protein tetramerization  (IEA)
proximal/distal pattern formation  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of epidermal cell division  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
skeletal system development  (IEA,ISO)
skin epidermis development  (IEA,ISO)
skin morphogenesis  (IEA,ISO)
spermatogenesis  (ISO)
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development  (IEA,ISO)
stem cell differentiation  (IEA,ISO)
stem cell proliferation  (IEA,ISO)
sympathetic nervous system development  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tp63
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602114,397,903 - 114,613,831 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936578491,507 - 705,729 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936578492,267 - 705,282 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TP63
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383189,596,746 - 189,897,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3189,631,389 - 189,897,276 (+)EnsemblGRCh38hg38GRCh38
GRCh373189,314,535 - 189,615,065 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363190,831,910 - 191,097,759 (+)NCBINCBI36Build 36hg18NCBI36
Celera3187,783,803 - 188,042,610 (+)NCBICelera
Cytogenetic Map3q28NCBI
HuRef3186,752,882 - 187,012,887 (+)NCBIHuRef
CHM1_13189,312,090 - 189,577,623 (+)NCBICHM1_1
T2T-CHM13v2.03192,413,470 - 192,713,713 (+)NCBIT2T-CHM13v2.0
Trp63
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391625,502,513 - 25,710,842 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1625,502,513 - 25,710,852 (+)EnsemblGRCm39 Ensembl
GRCm381625,683,763 - 25,892,088 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1625,683,763 - 25,892,102 (+)EnsemblGRCm38mm10GRCm38
MGSCv371625,683,851 - 25,892,174 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361625,717,291 - 25,807,429 (+)NCBIMGSCv36mm8
Celera1626,227,614 - 26,435,704 (+)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1617.37NCBI
Tp63
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81188,343,647 - 88,554,543 (-)NCBIGRCr8
mRatBN7.21174,838,858 - 75,049,764 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1174,838,859 - 75,049,398 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1183,648,386 - 83,858,432 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01176,283,447 - 76,493,481 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01175,342,697 - 75,553,279 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01178,234,853 - 78,456,559 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,234,800 - 78,456,501 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,262,234 - 82,484,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41176,900,622 - 77,200,251 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11176,958,211 - 77,257,840 (-)NCBI
Celera1173,744,494 - 73,953,104 (-)NCBICelera
Cytogenetic Map11q22NCBI
Tp63
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542018,176,155 - 18,384,786 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542018,178,639 - 18,384,786 (-)NCBIChiLan1.0ChiLan1.0
TP63
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22187,462,332 - 187,762,966 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13187,467,050 - 187,767,682 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03186,651,879 - 186,918,300 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13195,172,810 - 195,473,085 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3195,199,167 - 195,474,104 (+)Ensemblpanpan1.1panPan2
TP63
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13421,766,861 - 21,985,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3421,766,496 - 21,983,046 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3425,860,495 - 26,078,655 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03421,700,749 - 21,919,495 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3421,700,663 - 21,918,660 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13421,716,204 - 21,934,749 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03421,710,660 - 21,927,985 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03421,951,749 - 22,170,136 (+)NCBIUU_Cfam_GSD_1.0
TP63
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13127,116,105 - 127,347,068 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113127,115,990 - 127,347,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213136,309,804 - 136,515,766 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TP63
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11583,861,489 - 84,126,675 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604157,444,595 - 57,708,553 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tp63
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473067,286,160 - 67,489,670 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473067,283,444 - 67,489,808 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000013787   ⟹   ENSSTOP00000012357
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936578492,528 - 705,282 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000031810   ⟹   ENSSTOP00000029541
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936578492,809 - 705,196 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000037638   ⟹   ENSSTOP00000027874
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936578491,507 - 583,339 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000039636   ⟹   ENSSTOP00000028691
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936578505,074 - 705,729 (-)Ensembl
RefSeq Acc Id: XM_005330974   ⟹   XP_005331031
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602114,397,903 - 114,491,485 (-)NCBI
SpeTri2.0NW_004936578492,267 - 583,339 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005330976   ⟹   XP_005331033
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602114,397,903 - 114,560,152 (-)NCBI
SpeTri2.0NW_004936578504,161 - 705,282 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005330977   ⟹   XP_005331034
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602114,400,821 - 114,560,152 (-)NCBI
SpeTri2.0NW_004936578505,453 - 705,196 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021730319   ⟹   XP_021585994
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602114,400,821 - 114,491,485 (-)NCBI
SpeTri2.0NW_004936578492,267 - 583,339 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021730320   ⟹   XP_021585995
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602114,400,821 - 114,491,473 (-)NCBI
SpeTri2.0NW_004936578492,740 - 583,280 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040270151   ⟹   XP_040126085
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602114,397,903 - 114,560,152 (-)NCBI
RefSeq Acc Id: XM_040270152   ⟹   XP_040126086
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602114,397,903 - 114,560,152 (-)NCBI
RefSeq Acc Id: XM_040270153   ⟹   XP_040126087
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602114,397,903 - 114,613,831 (-)NCBI
RefSeq Acc Id: XM_040270154   ⟹   XP_040126088
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602114,412,302 - 114,491,485 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005331031   ⟸   XM_005330974
- Peptide Label: isoform X4
- UniProtKB: A0A287D2W7 (UniProtKB/TrEMBL),   I3MLP5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005331033   ⟸   XM_005330976
- Peptide Label: isoform X5
- UniProtKB: A0A287D7P9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005331034   ⟸   XM_005330977
- Peptide Label: isoform X6
- UniProtKB: A0A287D7P9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021585994   ⟸   XM_021730319
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_021585995   ⟸   XM_021730320
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_040126087   ⟸   XM_040270153
- Peptide Label: isoform X3
- UniProtKB: I3MLP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040126086   ⟸   XM_040270152
- Peptide Label: isoform X2
- UniProtKB: I3MLP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040126085   ⟸   XM_040270151
- Peptide Label: isoform X1
- UniProtKB: I3MLP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040126088   ⟸   XM_040270154
- Peptide Label: isoform X9
RefSeq Acc Id: ENSSTOP00000027874   ⟸   ENSSTOT00000037638
RefSeq Acc Id: ENSSTOP00000028691   ⟸   ENSSTOT00000039636
RefSeq Acc Id: ENSSTOP00000012357   ⟸   ENSSTOT00000013787
RefSeq Acc Id: ENSSTOP00000029541   ⟸   ENSSTOT00000031810
Protein Domains
p53 DNA-binding   p53 tetramerisation   SAM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000013771 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000013787.3 UniProtKB/TrEMBL
  ENSSTOT00000031810.1 UniProtKB/TrEMBL
  ENSSTOT00000037638.1 UniProtKB/TrEMBL
  ENSSTOT00000039636.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.60.40.720 UniProtKB/TrEMBL
  4.10.170.10 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  p53/RUNT-type_TF_DNA-bd_sf UniProtKB/TrEMBL
  p53_DNA-bd UniProtKB/TrEMBL
  p53_tetramer_sf UniProtKB/TrEMBL
  p53_tetrameristn UniProtKB/TrEMBL
  p53_tumour_suppressor UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  Tumor-p63_SAM UniProtKB/TrEMBL
NCBI Gene Tp63 ENTREZGENE
PANTHER PTHR11447 UniProtKB/TrEMBL
  PTHR11447:SF8 UniProtKB/TrEMBL
Pfam P53 UniProtKB/TrEMBL
  P53_tetramer UniProtKB/TrEMBL
  SAM_2 UniProtKB/TrEMBL
PRINTS P53SUPPRESSR UniProtKB/TrEMBL
PROSITE P53 UniProtKB/TrEMBL
SMART SAM UniProtKB/TrEMBL
Superfamily-SCOP SSF47719 UniProtKB/TrEMBL
  SSF47769 UniProtKB/TrEMBL
  SSF49417 UniProtKB/TrEMBL
UniProt A0A287D2W7 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D527_ICTTR UniProtKB/TrEMBL
  A0A287D7P9 ENTREZGENE, UniProtKB/TrEMBL
  I3MLP5 ENTREZGENE, UniProtKB/TrEMBL