Smad7 (SMAD family member 7) - Rat Genome Database

Name: Smad7
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Smad7 (SMAD family member 7) Ictidomys tridecemlineatus

Analyze

Symbol:

Smad7

Name:

SMAD family member 7

RGD ID:

12632089

Description:

ENCODES a protein that exhibits ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); intracellular signal transduction (ortholog); negative regulation of BMP signaling pathway (ortholog); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; Bone morphogenetic proteins signaling pathway; colorectal cancer pathway; ASSOCIATED WITH atrial fibrillation (ortholog); colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); FOUND IN adherens junction (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

mothers against decapentaplegic homolog 7; SMAD family member 7, transcript variant X1; SMAD family member 7, transcript variant X2

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SMAD7 (SMAD family member 7)	NCBI	Ortholog
Mus musculus (house mouse):	Smad7 (SMAD family member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Smad7 (SMAD family member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Smad7 (SMAD family member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SMAD7 (SMAD family member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SMAD7 (SMAD family member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SMAD7 (SMAD family member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SMAD7 (SMAD family member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Smad7 (SMAD family member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	38,655,545 - 38,682,943 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936497	13,894,580 - 13,922,065 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936497	13,894,586 - 13,921,978 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atrial fibrillation (ISO)

colorectal cancer (ISO)

Colorectal Neoplasms (ISO)

endometrial cancer (ISO)

familial adenomatous polyposis 4 (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

hereditary breast ovarian cancer syndrome (ISO)

Hypoglossal Nerve Injuries (ISO)

intellectual disability (ISO)

liver cirrhosis (ISO)

nephritis (ISO)

Ovarian Neoplasms (ISO)

pancreatic adenocarcinoma (ISO)

pancreatic cancer (ISO)

Paraquat Lung (ISO)

pulmonary fibrosis (ISO)

pulmonary hypertension (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adherens junction assembly (IEA)

artery morphogenesis (IEA)

cellular response to leukemia inhibitory factor (IEA,ISO)

cellular response to transforming growth factor beta stimulus (IEA)

intracellular signal transduction (ISO)

negative regulation of BMP signaling pathway (IEA,ISO)

negative regulation of chondrocyte proliferation (IEA)

negative regulation of DNA-binding transcription factor activity (IEA)

negative regulation of DNA-templated transcription (ISO)

negative regulation of ossification (IEA)

negative regulation of pathway-restricted SMAD protein phosphorylation (IEA)

negative regulation of peptidyl-serine phosphorylation (IEA)

negative regulation of peptidyl-threonine phosphorylation (IEA)

negative regulation of protein ubiquitination (IEA)

negative regulation of T cell cytokine production (IEA)

negative regulation of T-helper 17 cell differentiation (IEA)

negative regulation of T-helper 17 type immune response (IEA)

negative regulation of transcription by competitive promoter binding (IEA)

negative regulation of transcription by RNA polymerase II (IEA)

negative regulation of transforming growth factor beta receptor signaling pathway (IEA)

negative regulation of ubiquitin-protein transferase activity (IEA)

pathway-restricted SMAD protein phosphorylation (IEA)

positive regulation of cell-cell adhesion (IEA)

positive regulation of chondrocyte hypertrophy (IEA)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (IEA)

positive regulation of protein ubiquitination (IEA)

protein stabilization (IEA)

protein-containing complex localization (IEA)

regulation of activin receptor signaling pathway (IEA)

regulation of cardiac muscle contraction (IEA)

regulation of DNA-templated transcription (IEA)

regulation of epithelial to mesenchymal transition (IEA)

regulation of transforming growth factor beta receptor signaling pathway (ISO)

response to laminar fluid shear stress (IEA)

transforming growth factor beta receptor signaling pathway (IEA,ISO)

ureteric bud development (IEA)

ventricular cardiac muscle tissue morphogenesis (IEA)

ventricular septum morphogenesis (IEA)

Cellular Component

adherens junction (IEA,ISO)

centrosome (IEA)

cytoplasm (IEA)

cytosol (IEA)

fibrillar center (IEA)

nucleoplasm (IEA)

nucleus (IEA)

plasma membrane (IEA)

protein-containing complex (IEA)

transcription regulator complex (IEA)

Molecular Function

activin binding (IEA)

beta-catenin binding (IEA)

collagen binding (IEA)

I-SMAD binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

transcription regulator inhibitor activity (IEA)

type I transforming growth factor beta receptor binding (IEA)

ubiquitin protein ligase binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

altered transforming growth factor-beta Smad dependent signaling pathway (ISO)

Bone morphogenetic proteins signaling pathway (ISO)

colorectal cancer pathway (ISO)

transforming growth factor-beta Smad dependent signaling pathway (ISO)

type II interferon signaling pathway (ISO)

References

Genomics

Comparative Map Data

Smad7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	38,655,545 - 38,682,943 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936497	13,894,580 - 13,922,065 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936497	13,894,586 - 13,921,978 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SMAD7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	48,919,853 - 48,950,965 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	18	48,919,853 - 48,950,965 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	46,446,223 - 46,477,335 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	44,700,221 - 44,731,079 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	44,700,221 - 44,731,079	NCBI
Celera	18	43,299,268 - 43,330,141 (-)	NCBI		Celera
Cytogenetic Map	18	q21.1	NCBI
HuRef	18	43,299,249 - 43,329,936 (-)	NCBI		HuRef
CHM1_1	18	46,441,162 - 46,472,026 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	49,115,112 - 49,146,228 (-)	NCBI		T2T-CHM13v2.0

Smad7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	75,500,436 - 75,529,006 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	75,500,600 - 75,529,006 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	75,367,365 - 75,395,935 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	75,367,529 - 75,395,935 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	75,527,019 - 75,555,588 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	75,492,894 - 75,521,292 (+)	NCBI		MGSCv36	mm8
Celera	18	76,602,062 - 76,630,688 (+)	NCBI		Celera
Cytogenetic Map	18	E3	NCBI

Smad7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	68,988,429 - 69,016,774 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	68,988,429 - 69,016,765 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	71,094,956 - 71,123,284 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	18	71,764,762 - 71,793,114 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	18	69,620,987 - 69,649,318 (+)	NCBI	Rnor_WKY
Rnor_6.0	18	71,395,830 - 71,424,164 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	71,395,830 - 71,424,157 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	70,530,559 - 70,558,932 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	72,294,803 - 72,323,354 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	72,368,075 - 72,396,625 (+)	NCBI
Celera	18	67,155,575 - 67,183,461 (+)	NCBI		Celera
Cytogenetic Map	18	q12.2	NCBI

Smad7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	34,028,063 - 34,058,291 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	34,028,184 - 34,058,949 (-)	NCBI	ChiLan1.0	ChiLan1.0

SMAD7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	18	52,147,312 - 52,178,129 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	42,306,324 - 42,337,214 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	45,659,375 - 45,689,505 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

SMAD7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	79,706,485 - 79,734,673 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	79,706,705 - 79,734,749 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	79,113,271 - 79,142,567 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	79,776,182 - 79,805,641 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	79,776,387 - 79,805,516 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	79,490,141 - 79,519,361 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	79,520,644 - 79,548,552 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	79,805,995 - 79,834,706 (+)	NCBI		UU_Cfam_GSD_1.0

SMAD7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	98,514,267 - 98,542,382 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	98,512,800 - 98,543,924 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	108,087,677 - 108,118,319 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SMAD7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	31,993,543 - 32,024,088 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	31,993,681 - 32,024,850 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	6,227,954 - 6,258,760 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Smad7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624778	12,415,282 - 12,444,835 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624778	12,415,364 - 12,444,882 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005323077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005323078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040273272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSTOT00000023561 ⟹ ENSSTOP00000015647

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936497	13,894,580 - 13,922,065 (+)	Ensembl

RefSeq Acc Id:

XM_005323077 ⟹ XP_005323134

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404944	38,655,545 - 38,682,943 (+)	NCBI
SpeTri2.0	NW_004936497	13,894,586 - 13,921,978 (+)	NCBI

Sequence:

show sequence

GCCGCCGCCGCTCCTGCCCGGGCCCCTGCTGTTGCTGTTGTCGCCTGCGCCTGCTGCCCCAACT
CGGCGCCCGACTTCTTCATGGTGTGCGGAGGTCATGTTCGCTCCTTAGCCGGCAAACGACTTTT
CTCCTCGCCTCCTCGCCCCGCATGTTCAGGACCAAACGATCTGCGCTCGTCCGGCGTCTCTGGA
GAAGCCGAGCGCCCGGCGGCGAGGACGAGGAGGAGGGCGCTGGGGGAGGCGGAGGAGGAGGCGA
GCTGCGGGGAGAAGGGGCGACGGACGGCCGGGCGCATGGGGCCGGTGGCGGCGGCGTGGGCAGG
GCTGGCTGCTGCCTGGGCAAGGCAGTCCGAGGTGCCAAAGGTCACCACCATCCCCATCCCCCAG
CCGCGGGCGCCGGCGCGGCCGGGGGCACCGAAGCGGATCTGAAGGCGCTCACGCACTCGGTGCT
TAAGAAACTGAAGGAGCGGCAGCTGGAGCTGCTGCTTCAGGCCGTGGAGTCCCGCGGCGGTACG
CGCACCGCGTGCCTCCTGCTGCCTGGCCGCCTGGACTGCAGGCTGGGCCCGGGGGCTCCCGCCA
GTGCGCAACCCGCGCAGCCGCCCTCGTCCTACTCGCTCCCCCTCCTGCTGTGCAAAGTGTTCAG
GTGGCCGGATCTCAGGCATTCCTCGGAAGTCAAGAGGCTGTGTTGCTGTGAATCTTACGGGAAG
ATCAACCCCGAGCTGGTGTGCTGCAACCCCCATCACCTTAGCAGACTCTGCGAACTAGAGTCTC
CCCCCCCTCCCTACTCCAGATACCCGATGGATTTTCTCAAGCCAACTGCAGACTGTCCAGATGC
TGTGCCTTCCTCCGCTGAAACAGGGGGAACAAATTATCTGGCCCCTGGGGGGCTTTCAGATTCC
CAACTTCTTCTGGAGCCTGGGGATCGGTCACACTGGTGCGTGGTGGCATACTGGGAGGAGAAGA
CGAGAGTGGGGAGGCTCTACTGTGTCCAGGAGCCTTCCCTGGATATCTTCTATGATCTACCTCA
GGGGAATGGCTTTTGCCTTGGACAGCTCAATTCCGACAACAAGAGTCAGCTGGTGCAGAAGGTG
CGGAGCAAGATCGGCTGCGGCATCCAGCTGACTCGGGAAGTGGACGGTGTGTGGGTGTACAACC
GCAGCAGTTACCCCATCTTCATCAAGTCCGCCACACTGGACAACCCAGACTCCAGGACGCTGCT
GGTGCACAAGGTGTTCCCCGGATTCTCCATCAAGGCTTTCGATTACGAGAAGGCGTACAGCCTG
CAGCGGCCCAACGACCACGAGTTCATGCAGCAGCCGTGGACGGGCTTCACCGTGCAGATCAGCT
TCGTGAAGGGCTGGGGCCAGTGCTACACCCGCCAGTTCATCAGCAGCTGCCCGTGCTGGCTAGA
GGTCATCTTCAACAGCCGGTAGCCGCTGGGGAGAGGACAGAGGTGGAGGTGGGGAGAGGACGAG
CGGGAGCCGGGCAGGCCACCATTCAAAACTACTTTGCTGCTAATCTTTTCCTCCCGAGTGCTTG
CTCTTCATGCAAACTCTTTGGTCGTTTCTTTTTGTTGTTCTTGTTGGTTTTTTTTTCTTTTTTG
TTGTTGTTGTCGATCTTGTCTGTGTTCTCTTTTGTTATTTGAGAAATAGCTTATGAAAAGAATT
GTTGGGTTTTTTTTTTTTTTTTTTGGAGGGGGTGGGTGTGGCTGGCAGGACATCCCTATCGGAA
GAGGGGAAACGAAAGTTGGAGTCCCGCCAAACACAGCGTATGAATGGGGGGCGCCCCTCCACTT
TTGGATCAGCATTTCATTTGTCGTGAGTGTGTGCATTTGTGTGTGTGCACGTGTGCGTGCGTGC
GTGCCTATGTGTGCATGAATGCGTGTGAACAGATGAGGAGTGAGTCCTCCGTGAGTTCCTTATG
GATGTCCCCGCTGGAGACGTTTGCGGTTTCAAGCTGTGTGTGTCTCATGCCCTTTGGACATGCT
CAGTGGGACAGAGGCTCTACCTGGCCAGGCTGGGGGCAGAGGCCCAGCAGCTGCCAGAAGCGAG
GTTCTGCCCAGCCTGGGAAGCCCCCTCCCCTCCTCCCTCTTTTAGGACACGGGCCTATCCACAG
GCTTCTGAGAAGCCAGCCTGCTAGAGGCTGAACCAGAACCAATTGCTTTCACCTTGTCCCGCTC
CCCTCCGCCAGCCTGCTGCCACTGTAGCATCTGTCTGTTTGGCCATCTGCTCCTGGCTTTCTCT
GAGATGGGCTTCCTGAGGGCTGCTGGGGCAGTACTGCTCACCTGGGGCCCTCGGGGGCCCTCCG
GCCTCTCCCCCTGCCCTGGTTCCATCACGTTTCTCCCAGGCTTCCAAGCCAGCTCAGCTCGCCC
CTCCCCTCCCCAGCTTTGTGTTGAGCTCTGCTGTTAGGCCAGCACCGGGGAGGGACCTGCTCCT
GGCCCCCTTCCCTCCAAGAAGGATCTGGTCCATCCTAACCCAAGGTACCACCCTAGCTGACACC
TAACCTCCTCCCATTCTTCTACAACTCATACGCTCGTATGATACTTTGACACTGTTCTTAGCTC
AATGAGCATGTTTAGACTTTAACATAAGCTATTTTTCTAACTACAAAGGTTTAAATGAACAAGA
GAAGCATTCTCATTGGAAATTTAGCATTGTAGTGCTTTGAGAGAGAAAGGACTCCTGGAAAAAA
GAAACCTGAGATTTATTAAAGAAAAAAAAATGTATTTTATGTTATATATAAATATATTATTACT
TGTAAATATAAAGACGTTTTATAAGCATCATTATTTATGTATTGTGCAATGTGTATAAACAAGA
AAAATAAAGAAAAGATGCACTTTGCTTTAATATAAATGCAAATAACAAATGCCAAATTAAAAAC
GATAAACACAAGATTGGTGTTTTTTCTATGGGTGTTATCACCTGGCTGAATGTTTTTCTAAAGG
AGTTTATGTTCCATTAAACAATTTTTAAAATGTA

hide sequence

RefSeq Acc Id:

XM_005323078 ⟹ XP_005323135

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404944	38,655,545 - 38,682,943 (+)	NCBI
SpeTri2.0	NW_004936497	13,894,586 - 13,921,978 (+)	NCBI

Sequence:

show sequence

GCCGCCGCCGCTCCTGCCCGGGCCCCTGCTGTTGCTGTTGTCGCCTGCGCCTGCTGCCCCAACT
CGGCGCCCGACTTCTTCATGGTGTGCGGAGGTCATGTTCGCTCCTTAGCCGGCAAACGACTTTT
CTCCTCGCCTCCTCGCCCCGCATGTTCAGGACCAAACGATCTGCGCTCGTCCGGCGTCTCTGGA
GAAGCCGAGCGCCCGGCGGCGAGGACGAGGAGGAGGGCGCTGGGGGAGGCGGAGGAGGAGGCGA
GCTGCGGGGAGAAGGGGCGACGGACGGCCGGGCGCATGGGGCCGGTGGCGGCGGCGTGGGCAGG
GCTGGCTGCTGCCTGGGCAAGGCAGTCCGAGGTGCCAAAGGTCACCACCATCCCCATCCCCCAG
CCGCGGGCGCCGGCGCGGCCGGGGGCACCGAAGCGGATCTGAAGGCGCTCACGCACTCGGTGCT
TAAGAAACTGAAGGAGCGGCAGCTGGAGCTGCTGCTTCAGGCCGTGGAGTCCCGCGGCGGTACG
CGCACCGCGTGCCTCCTGCTGCCTGGCCGCCTGGACTGCAGGCTGGGCCCGGGGGCTCCCGCCA
GTGCGCAACCCGCGCAGCCGCCCTCGTCCTACTCGCTCCCCCTCCTGCTGTGCAAAGTGTTCAG
GTGGCCGGATCTCAGGCATTCCTCGGAAGTCAAGAGGCTGTGTTGCTGTGAATCTTACGGGAAG
ATCAACCCCGAGCTGGTGTGCTGCAACCCCCATCACCTTAGCAGACTCTGCGAACTAGAGTCTC
CCCCCCCTCCCTACTCCAGATACCCGATGGATTTTCTCAAGCCAACTGACTGTCCAGATGCTGT
GCCTTCCTCCGCTGAAACAGGGGGAACAAATTATCTGGCCCCTGGGGGGCTTTCAGATTCCCAA
CTTCTTCTGGAGCCTGGGGATCGGTCACACTGGTGCGTGGTGGCATACTGGGAGGAGAAGACGA
GAGTGGGGAGGCTCTACTGTGTCCAGGAGCCTTCCCTGGATATCTTCTATGATCTACCTCAGGG
GAATGGCTTTTGCCTTGGACAGCTCAATTCCGACAACAAGAGTCAGCTGGTGCAGAAGGTGCGG
AGCAAGATCGGCTGCGGCATCCAGCTGACTCGGGAAGTGGACGGTGTGTGGGTGTACAACCGCA
GCAGTTACCCCATCTTCATCAAGTCCGCCACACTGGACAACCCAGACTCCAGGACGCTGCTGGT
GCACAAGGTGTTCCCCGGATTCTCCATCAAGGCTTTCGATTACGAGAAGGCGTACAGCCTGCAG
CGGCCCAACGACCACGAGTTCATGCAGCAGCCGTGGACGGGCTTCACCGTGCAGATCAGCTTCG
TGAAGGGCTGGGGCCAGTGCTACACCCGCCAGTTCATCAGCAGCTGCCCGTGCTGGCTAGAGGT
CATCTTCAACAGCCGGTAGCCGCTGGGGAGAGGACAGAGGTGGAGGTGGGGAGAGGACGAGCGG
GAGCCGGGCAGGCCACCATTCAAAACTACTTTGCTGCTAATCTTTTCCTCCCGAGTGCTTGCTC
TTCATGCAAACTCTTTGGTCGTTTCTTTTTGTTGTTCTTGTTGGTTTTTTTTTCTTTTTTGTTG
TTGTTGTCGATCTTGTCTGTGTTCTCTTTTGTTATTTGAGAAATAGCTTATGAAAAGAATTGTT
GGGTTTTTTTTTTTTTTTTTTGGAGGGGGTGGGTGTGGCTGGCAGGACATCCCTATCGGAAGAG
GGGAAACGAAAGTTGGAGTCCCGCCAAACACAGCGTATGAATGGGGGGCGCCCCTCCACTTTTG
GATCAGCATTTCATTTGTCGTGAGTGTGTGCATTTGTGTGTGTGCACGTGTGCGTGCGTGCGTG
CCTATGTGTGCATGAATGCGTGTGAACAGATGAGGAGTGAGTCCTCCGTGAGTTCCTTATGGAT
GTCCCCGCTGGAGACGTTTGCGGTTTCAAGCTGTGTGTGTCTCATGCCCTTTGGACATGCTCAG
TGGGACAGAGGCTCTACCTGGCCAGGCTGGGGGCAGAGGCCCAGCAGCTGCCAGAAGCGAGGTT
CTGCCCAGCCTGGGAAGCCCCCTCCCCTCCTCCCTCTTTTAGGACACGGGCCTATCCACAGGCT
TCTGAGAAGCCAGCCTGCTAGAGGCTGAACCAGAACCAATTGCTTTCACCTTGTCCCGCTCCCC
TCCGCCAGCCTGCTGCCACTGTAGCATCTGTCTGTTTGGCCATCTGCTCCTGGCTTTCTCTGAG
ATGGGCTTCCTGAGGGCTGCTGGGGCAGTACTGCTCACCTGGGGCCCTCGGGGGCCCTCCGGCC
TCTCCCCCTGCCCTGGTTCCATCACGTTTCTCCCAGGCTTCCAAGCCAGCTCAGCTCGCCCCTC
CCCTCCCCAGCTTTGTGTTGAGCTCTGCTGTTAGGCCAGCACCGGGGAGGGACCTGCTCCTGGC
CCCCTTCCCTCCAAGAAGGATCTGGTCCATCCTAACCCAAGGTACCACCCTAGCTGACACCTAA
CCTCCTCCCATTCTTCTACAACTCATACGCTCGTATGATACTTTGACACTGTTCTTAGCTCAAT
GAGCATGTTTAGACTTTAACATAAGCTATTTTTCTAACTACAAAGGTTTAAATGAACAAGAGAA
GCATTCTCATTGGAAATTTAGCATTGTAGTGCTTTGAGAGAGAAAGGACTCCTGGAAAAAAGAA
ACCTGAGATTTATTAAAGAAAAAAAAATGTATTTTATGTTATATATAAATATATTATTACTTGT
AAATATAAAGACGTTTTATAAGCATCATTATTTATGTATTGTGCAATGTGTATAAACAAGAAAA
ATAAAGAAAAGATGCACTTTGCTTTAATATAAATGCAAATAACAAATGCCAAATTAAAAACGAT
AAACACAAGATTGGTGTTTTTTCTATGGGTGTTATCACCTGGCTGAATGTTTTTCTAAAGGAGT
TTATGTTCCATTAAACAATTTTTAAAATGTA

hide sequence

RefSeq Acc Id:

XM_040273272 ⟹ XP_040129206

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404944	38,655,551 - 38,682,943 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005323134	(Get FASTA)	NCBI Sequence Viewer
	XP_005323135	(Get FASTA)	NCBI Sequence Viewer
	XP_040129206	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	KAG3293905	(Get FASTA)	NCBI Sequence Viewer
	KAG3293906	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_005323134 ⟸ XM_005323077
- Peptide Label:	isoform X1
- UniProtKB:	I3MU52 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFRTKRSALVRRLWRSRAPGGEDEEEGAGGGGGGGELRGEGATDGRAHGAGGGGVGRAGCCLGK AVRGAKGHHHPHPPAAGAGAAGGTEADLKALTHSVLKKLKERQLELLLQAVESRGGTRTACLLL PGRLDCRLGPGAPASAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVC CNPHHLSRLCELESPPPPYSRYPMDFLKPTADCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPG DRSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCG IQLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHE FMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNSR hide sequence

RefSeq Acc Id:

XP_005323135 ⟸ XM_005323078

- Peptide Label:

isoform X2

- Sequence:

show sequence

MFRTKRSALVRRLWRSRAPGGEDEEEGAGGGGGGGELRGEGATDGRAHGAGGGGVGRAGCCLGK
AVRGAKGHHHPHPPAAGAGAAGGTEADLKALTHSVLKKLKERQLELLLQAVESRGGTRTACLLL
PGRLDCRLGPGAPASAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVC
CNPHHLSRLCELESPPPPYSRYPMDFLKPTDCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPGD
RSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGI
QLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEF
MQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNSR

hide sequence

RefSeq Acc Id:	XP_040129206 ⟸ XM_040273272
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSSTOP00000015647 ⟸ ENSSTOT00000023561

Protein Domains

MH1 MH2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000020985	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSSTOP00000015647	ENTREZGENE
	ENSSTOP00000015647.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000023561.2	UniProtKB/TrEMBL
Gene3D-CATH	2.60.200.10	UniProtKB/TrEMBL
	3.90.520.10	UniProtKB/TrEMBL
InterPro	Dwarfin	UniProtKB/TrEMBL
	MAD_homology1_Dwarfin-type	UniProtKB/TrEMBL
	MAD_homology_MH1	UniProtKB/TrEMBL
	SMAD-like_dom_sf	UniProtKB/TrEMBL
	SMAD_dom_Dwarfin-type	UniProtKB/TrEMBL
	SMAD_FHA_dom_sf	UniProtKB/TrEMBL
	SMAD_MH1_sf	UniProtKB/TrEMBL
NCBI Gene	Smad7	ENTREZGENE
PANTHER	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7	UniProtKB/TrEMBL
	PTHR13703	UniProtKB/TrEMBL
Pfam	MH1	UniProtKB/TrEMBL
	MH2	UniProtKB/TrEMBL
PROSITE	MH1	UniProtKB/TrEMBL
	MH2	UniProtKB/TrEMBL
SMART	DWA	UniProtKB/TrEMBL
	DWB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49879	UniProtKB/TrEMBL
	SSF56366	UniProtKB/TrEMBL
UniProt	I3MU52	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)