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ONTOLOGY REPORT - ANNOTATIONS

Term:extracellular matrix disassembly
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Accession:GO:0022617 term browser browse the term
Definition:A process that results in the breakdown of the extracellular matrix.


show annotations for term's descendants           Sort by:
extracellular matrix disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM10 ADAM metallopeptidase domain 10 involved_in TAS Reactome Reactome:R-HSA-1474228 NCBI chr15:58,588,809...58,749,707
Ensembl chr15:58,588,809...58,749,791 		JBrowse link
G ADAM15 ADAM metallopeptidase domain 15 involved_in TAS Reactome Reactome:R-HSA-1474228 NCBI chr 1:155,051,316...155,062,775
Ensembl chr 1:155,050,566...155,062,775 		JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 involved_in TAS Reactome Reactome:R-HSA-1474228 NCBI chr10:133,262,423...133,276,868
Ensembl chr10:133,262,420...133,276,868 		JBrowse link
G ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr11:130,448,645...130,476,645
Ensembl chr11:130,448,645...130,476,645 		JBrowse link
G ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 involved_in TAS Reactome Reactome:R-HSA-1474228 NCBI chr 1:161,184,302...161,199,054
Ensembl chr 1:161,184,302...161,199,054 		JBrowse link
G ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 involved_in IEA
ISS
TAS		 Ensembl
UniProt
Reactome		 GO_REF:0000024 GO_REF:0000107 Reactome:R-HSA-1474228 NCBI chr21:26,917,922...26,967,088
Ensembl chr21:26,917,922...26,967,088 		JBrowse link
G CAPG capping actin protein, gelsolin like NOT|involved_in IMP (PMID:24236012) UniProt PMID:24236012 NCBI chr 2:85,391,602...85,419,540
Ensembl chr 2:85,394,753...85,418,432 		JBrowse link
G CMA1 chymase 1 involved_in IDA (PMID:27068509) BHF-UCL PMID:27068509 NCBI chr14:24,505,353...24,508,265
Ensembl chr14:24,505,353...24,508,265 		JBrowse link
G CTSG cathepsin G involved_in TAS Reactome Reactome:R-HSA-1474228 NCBI chr14:24,573,518...24,576,250
Ensembl chr14:24,573,518...24,576,250 		JBrowse link
G CTSK cathepsin K involved_in TAS Reactome Reactome:R-HSA-1474228 Reactome:R-HSA-1592389 NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577 		JBrowse link
G CTSS cathepsin S involved_in TAS Reactome Reactome:R-HSA-1474228 NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,079...150,765,957 		JBrowse link
G CTSV cathepsin V involved_in TAS Reactome Reactome:R-HSA-1474228 Reactome:R-HSA-1592389 NCBI chr 9:97,029,677...97,039,643
Ensembl chr 9:97,029,677...97,156,556 		JBrowse link
G ELANE elastase, neutrophil expressed involved_in TAS Reactome Reactome:R-HSA-1474228 NCBI chr19:852,303...856,243
Ensembl chr19:851,014...856,247 		JBrowse link
G ENG endoglin involved_in IMP (PMID:18223685) BHF-UCL PMID:18223685 NCBI chr 9:127,815,016...127,854,658
Ensembl chr 9:127,815,013...127,854,658 		JBrowse link
G EXOC8 exocyst complex component 8 involved_in IMP (PMID:24344185) UniProt PMID:24344185 NCBI chr 1:231,332,753...231,337,852
Ensembl chr 1:231,332,753...231,337,852 		JBrowse link
G FLOT1 flotillin 1 involved_in IMP (PMID:21119006) UniProt PMID:21119006 NCBI chr 6:30,727,709...30,742,687
Ensembl chr 6:30,727,709...30,742,732 		JBrowse link
G FURIN furin, paired basic amino acid cleaving enzyme involved_in TAS Reactome Reactome:R-HSA-1592389 NCBI chr15:90,868,588...90,883,457
Ensembl chr15:90,868,588...90,883,564 		JBrowse link
G GSN gelsolin NOT|involved_in IMP (PMID:24236012) UniProt PMID:24236012 NCBI chr 9:121,201,483...121,332,842
Ensembl chr 9:121,207,794...121,332,843 		JBrowse link
G KIF9 kinesin family member 9 involved_in IMP (PMID:21119006) UniProt PMID:21119006 NCBI chr 3:47,227,998...47,282,799
Ensembl chr 3:47,227,998...47,283,451 		JBrowse link
G KLK4 kallikrein related peptidase 4 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:22243248) Ensembl
MGI
GO_Central
TreeGrafter		 PMID:22243248 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr19:50,906,351...50,911,395
Ensembl chr19:50,906,351...50,911,395 		JBrowse link
G KLK5 kallikrein related peptidase 5 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr19:50,943,303...50,953,038
Ensembl chr19:50,943,303...50,953,093 		JBrowse link
G KLK7 kallikrein related peptidase 7 involved_in TAS Reactome Reactome:R-HSA-1474228 NCBI chr19:50,976,468...50,984,064
Ensembl chr19:50,976,468...50,984,099 		JBrowse link
G LAMC1 laminin subunit gamma 1 involved_in IMP (PMID:15159456) HGNC-UCL PMID:15159456 NCBI chr 1:183,023,420...183,145,592
Ensembl chr 1:183,023,420...183,145,592 		JBrowse link
G LCP1 lymphocyte cytosolic protein 1 involved_in IMP (PMID:24236012) UniProt PMID:24236012 NCBI chr13:46,125,923...46,182,177
Ensembl chr13:46,125,920...46,211,871 		JBrowse link
G MMP1 matrix metallopeptidase 1 involved_in TAS Reactome Reactome:R-HSA-1474228 Reactome:R-HSA-1592389 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160 		JBrowse link
G MMP10 matrix metallopeptidase 10 involved_in TAS Reactome Reactome:R-HSA-1474228 Reactome:R-HSA-1592389 NCBI chr11:102,770,502...102,780,628
Ensembl chr11:102,770,502...102,780,628 		JBrowse link
G MMP11 matrix metallopeptidase 11 involved_in TAS Reactome Reactome:R-HSA-1592389 NCBI chr22:23,772,849...23,784,316
Ensembl chr22:23,768,226...23,784,316 		JBrowse link
G MMP12 matrix metallopeptidase 12 involved_in TAS Reactome Reactome:R-HSA-1474228 NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982 		JBrowse link
G MMP13 matrix metallopeptidase 13 involved_in IMP
IEA
TAS		 (PMID:8576151), (PMID:9065415) UniProt
Ensembl
Reactome		 PMID:8576151 PMID:9065415 GO_REF:0000107 Reactome:R-HSA-1474228 Reactome:R-HSA-1592389 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732 		JBrowse link
G MMP14 matrix metallopeptidase 14 involved_in TAS Reactome Reactome:R-HSA-1474228 Reactome:R-HSA-1592389 NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,041 		JBrowse link
G MMP15 matrix metallopeptidase 15 involved_in TAS Reactome Reactome:R-HSA-1474228 NCBI chr16:58,025,754...58,046,901
Ensembl chr16:58,025,754...58,046,901 		JBrowse link
G MMP19 matrix metallopeptidase 19 involved_in TAS Reactome Reactome:R-HSA-1474228 NCBI chr12:55,835,433...55,842,936
Ensembl chr12:55,835,433...55,842,966 		JBrowse link
G MMP2 matrix metallopeptidase 2 involved_in TAS (PMID:24970228) Reactome PMID:24970228 Reactome:R-HSA-1474228 Reactome:R-HSA-1592389 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP20 matrix metallopeptidase 20 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22243248) Ensembl
MGI		 PMID:22243248 GO_REF:0000107 NCBI chr11:102,576,832...102,625,332
Ensembl chr11:102,576,832...102,625,332 		JBrowse link
G MMP3 matrix metallopeptidase 3 involved_in TAS Reactome Reactome:R-HSA-1474228 Reactome:R-HSA-1592389 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609 		JBrowse link
G MMP7 matrix metallopeptidase 7 involved_in TAS Reactome Reactome:R-HSA-1474228 Reactome:R-HSA-1592389 NCBI chr11:102,520,508...102,530,747
Ensembl chr11:102,520,508...102,530,750 		JBrowse link
G MMP8 matrix metallopeptidase 8 involved_in TAS Reactome Reactome:R-HSA-1474228 NCBI chr11:102,711,796...102,724,954
Ensembl chr11:102,711,796...102,727,050 		JBrowse link
G MMP9 matrix metallopeptidase 9 involved_in TAS Reactome Reactome:R-HSA-1474228 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NOXO1 NADPH oxidase organizer 1 involved_in IMP (PMID:19755710) UniProt PMID:19755710 NCBI chr16:1,978,917...1,981,469
Ensembl chr16:1,978,917...1,984,192 		JBrowse link
G PBXIP1 PBX homeobox interacting protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30659184) Ensembl
MGI		 PMID:30659184 GO_REF:0000107 NCBI chr 1:154,944,080...154,956,099
Ensembl chr 1:154,944,076...154,956,123 		JBrowse link
G PLG plasminogen involved_in IDA (PMID:14699093) BHF-UCL PMID:14699093 NCBI chr 6:160,702,193...160,754,097
Ensembl chr 6:160,702,194...160,754,097 		JBrowse link
G PRSS1 serine protease 1 involved_in TAS Reactome Reactome:R-HSA-1592389 NCBI chr 7:142,749,472...142,753,072
Ensembl chr 7:142,749,468...142,753,072 		JBrowse link
G PRSS2 serine protease 2 involved_in TAS Reactome Reactome:R-HSA-1592389 NCBI chr 7:142,770,970...142,774,560
Ensembl chr 7:142,760,398...142,774,564 		JBrowse link
G SH3PXD2B SH3 and PX domains 2B involved_in IMP (PMID:19755710) UniProt PMID:19755710 NCBI chr 5:172,325,181...172,454,525
Ensembl chr 5:172,325,000...172,454,525 		JBrowse link
G TMPRSS6 transmembrane serine protease 6 involved_in TAS Reactome Reactome:R-HSA-1474228 NCBI chr22:37,065,436...37,110,536
Ensembl chr22:37,065,436...37,109,713 		JBrowse link
G TPSAB1 tryptase alpha/beta 1 involved_in IDA (PMID:27068509) BHF-UCL PMID:27068509 NCBI chr16:1,240,705...1,242,554
Ensembl chr16:1,239,266...1,242,554 		JBrowse link
G WASHC1 WASH complex subunit 1 involved_in IMP (PMID:24344185) UniProt PMID:24344185 NCBI chr 9:14,513...30,487
Ensembl chr 9:14,475...73,865 		JBrowse link
G WDR72 WD repeat domain 72 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26247047) Ensembl
MGI		 PMID:26247047 GO_REF:0000107 NCBI chr15:53,513,741...53,762,878
Ensembl chr15:53,513,741...53,762,878 		JBrowse link
basement membrane disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMA1 chymase 1 involved_in IDA (PMID:27068509) BHF-UCL PMID:27068509 NCBI chr14:24,505,353...24,508,265
Ensembl chr14:24,505,353...24,508,265 		JBrowse link
G CTSS cathepsin S involved_in IDA (PMID:22952693) BHF-UCL PMID:22952693 NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,079...150,765,957 		JBrowse link
G HPN hepsin involved_in IDA (PMID:16908524) UniProt PMID:16908524 NCBI chr19:35,040,506...35,066,573
Ensembl chr19:35,040,506...35,066,573 		JBrowse link
biofilm matrix disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTSG cathepsin G involved_in IDA (PMID:32995850) UniProt PMID:32995850 NCBI chr14:24,573,518...24,576,250
Ensembl chr14:24,573,518...24,576,250 		JBrowse link
negative regulation of extracellular matrix disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CST3 cystatin C involved_in IC
IMP		 (PMID:7890620)
(PMID:10545518)		 BHF-UCL PMID:7890620 PMID:10545518 NCBI chr20:23,626,706...23,637,955
Ensembl chr20:23,626,706...23,638,473 		JBrowse link
G DPP4 dipeptidyl peptidase 4 involved_in IDA (PMID:16651416) UniProt PMID:16651416 NCBI chr 2:161,992,245...162,074,215
Ensembl chr 2:161,992,245...162,074,394 		JBrowse link
G FAP fibroblast activation protein alpha involved_in IDA (PMID:16651416) UniProt PMID:16651416 NCBI chr 2:162,170,684...162,243,445
Ensembl chr 2:162,170,684...162,245,151 		JBrowse link
G MIR29B1 microRNA 29b-1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 7:130,877,459...130,877,539
Ensembl chr 7:130,877,459...130,877,539 		JBrowse link
G MIR29B2 microRNA 29b-2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 1:207,802,443...207,802,523
Ensembl chr 1:207,802,443...207,802,523 		JBrowse link
G MIR98 microRNA 98 involved_in IDA (PMID:26587789) ARUK-UCL PMID:26587789 NCBI chr  X:53,556,223...53,556,341
Ensembl chr  X:53,556,223...53,556,341 		JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in TAS (PMID:22269326) BHF-UCL PMID:22269326 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
positive regulation of extracellular matrix disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARMIL2 capping protein regulator and myosin 1 linker 2 involved_in IDA (PMID:26466680), (PMID:26578515) UniProt PMID:26466680 PMID:26578515 NCBI chr16:67,645,144...67,657,569
Ensembl chr16:67,644,988...67,657,569 		JBrowse link
G CLASP1 cytoplasmic linker associated protein 1 involved_in IMP (PMID:24859005) UniProt PMID:24859005 NCBI chr 2:121,337,776...121,649,462
Ensembl chr 2:121,337,776...121,649,476 		JBrowse link
G CLASP2 cytoplasmic linker associated protein 2 involved_in IMP (PMID:24859005) UniProt PMID:24859005 NCBI chr 3:33,496,245...33,718,254
Ensembl chr 3:33,496,245...33,718,356 		JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:162,630,863...162,787,405
Ensembl chr 1:162,631,373...162,787,405 		JBrowse link
G FSCN1 fascin actin-bundling protein 1 involved_in IDA (PMID:20137952) UniProt PMID:20137952 NCBI chr 7:5,592,816...5,606,655
Ensembl chr 7:5,592,816...5,606,655 		JBrowse link
G IL6 interleukin 6 involved_in IMP (PMID:26587789) ARUK-UCL PMID:26587789 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MELTF melanotransferrin involved_in IDA (PMID:16713448) UniProt PMID:16713448 NCBI chr 3:197,001,740...197,029,817
Ensembl chr 3:196,980,590...197,029,835 		JBrowse link
G PDPN podoplanin involved_in IDA (PMID:25486435) UniProt PMID:25486435 NCBI chr 1:13,583,757...13,617,957
Ensembl chr 1:13,583,465...13,617,957 		JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISO (MGI:5688835|PMID:21984612) UniProt PMID:21984612 MGI:5688835 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
regulation of extracellular matrix disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDR1 discoidin domain receptor tyrosine kinase 1 involved_in IMP
IEA		 (PMID:12065315) UniProt
Ensembl		 PMID:12065315 GO_REF:0000107 NCBI chr 6:30,880,970...30,900,156
Ensembl chr 6:30,876,421...30,900,156 		JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 involved_in TAS (PMID:16626936) UniProt PMID:16626936 NCBI chr 1:162,630,863...162,787,405
Ensembl chr 1:162,631,373...162,787,405 		JBrowse link
G ETS1 ETS proto-oncogene 1, transcription factor ISO RGD PMID:16738537 RGD:2313717 NCBI chr11:128,458,765...128,587,558
Ensembl chr11:128,458,761...128,587,558 		JBrowse link
G FGFR4 fibroblast growth factor receptor 4 involved_in IMP (PMID:20876804) UniProt PMID:20876804 NCBI chr 5:177,086,915...177,098,144
Ensembl chr 5:177,086,905...177,098,144 		JBrowse link
G LRP1 LDL receptor related protein 1 involved_in TAS (PMID:14645246) ParkinsonsUK-UCL PMID:14645246 NCBI chr12:57,128,483...57,213,361
Ensembl chr12:57,128,483...57,213,361 		JBrowse link
G MIR195 microRNA 195 involved_in ISS (PMID:25201911) ARUK-UCL PMID:25201911 NCBI chr17:7,017,615...7,017,701
Ensembl chr17:7,017,615...7,017,701 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    cellular process 18301
      cellular component organization or biogenesis 7549
        cellular component organization 7324
          cellular component disassembly 587
            extracellular matrix disassembly 70
              basement membrane disassembly + 3
              biofilm matrix disassembly 1
              negative regulation of extracellular matrix disassembly 7
              positive regulation of extracellular matrix disassembly 9
              regulation of extracellular matrix disassembly + 21
Path 2
Term Annotations click to browse term
  biological_process 19669
    cellular process 18301
      cellular component organization or biogenesis 7549
        cellular component organization 7324
          extracellular structure organization 379
            extracellular matrix organization 378
              extracellular matrix disassembly 70
                basement membrane disassembly + 3
                biofilm matrix disassembly 1
                negative regulation of extracellular matrix disassembly 7
                positive regulation of extracellular matrix disassembly 9
                regulation of extracellular matrix disassembly + 21
paths to the root