RGD Reference Report - Transcription factor Ets-1 is essential for mesangial matrix remodeling. - Rat Genome Database

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Transcription factor Ets-1 is essential for mesangial matrix remodeling.

Authors: Mizui, M  Isaka, Y  Takabatake, Y  Sato, Y  Kawachi, H  Shimizu, F  Takahara, S  Ito, T  Imai, E 
Citation: Mizui M, etal., Kidney Int. 2006 Jul;70(2):298-305. Epub 2006 May 31.
RGD ID: 2313717
Pubmed: PMID:16738537   (View Abstract at PubMed)
DOI: DOI:10.1038/sj.ki.5001541   (Journal Full-text)

Most advanced glomerular diseases are characterized by abnormal extracellular matrix (ECM) accumulation in the glomeruli, and matrix metalloproteinases (MMPs) play a pivotal role in ECM remodeling in various glomerular diseases. The proto-oncogene, ets-1, is a transcription factor regulating the expression of various matrix proteinases, including MMP-1, MMP-3, and MMP-9. The goal of the present study was to characterize the role of Ets-1 in the progression of glomerular diseases. Overexpression of Ets-1 in cultured mesangial cells prevented transforming growth factor (TGF)-beta-induced inhibition of DNA-binding activity and TGF-beta-induced type I collagen production. In addition, exogenous Ets-1 abolished TGF-beta-induced collagen gel contraction. The in vivo transfection of the ets-1 gene into nephritic kidney resulted in the increases in glomerular MMP-1, MMP-3, and MMP-9 mRNA, decreases in mesangial ECM deposition, and attenuation of fibronectin extradomain A (EDA) and type I collagen expression. In contrast, knockdown of Ets-1 in glomeruli resulted in severe ECM deposition in diseased glomeruli. In conclusion, Ets-1 promotes degradation of ECM proteins and is critical for integral glomerular reorganization.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ets1Ratregulation of extracellular matrix disassembly  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ets1  (ETS proto-oncogene 1, transcription factor)


Additional Information