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Gene: TMPRSS6 (transmembrane serine protease 6) Homo sapiens
Symbol: TMPRSS6
Name: transmembrane serine protease 6
Description: Predicted to have serine-type endopeptidase activity. Involved in iron ion homeostasis; negative regulation of transcription, DNA-templated; and proteolysis. Localizes to extracellular space and plasma membrane. Implicated in microcytic anemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IRIDA; matriptase-2; membrane-bound mosaic serine proteinase matriptase-2; MT2; transmembrane protease serine 6; transmembrane protease, serine 6; type II transmembrane serine protease 6
Mus musculus (house mouse) : Tmprss6 (transmembrane serine protease 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tmprss6 (transmembrane serine protease 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tmprss6 (transmembrane serine protease 6)
Pan paniscus (bonobo/pygmy chimpanzee) : TMPRSS6 (transmembrane serine protease 6)
Canis lupus familiaris (dog) : TMPRSS6 (transmembrane serine protease 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tmprss6 (transmembrane serine protease 6)
Sus scrofa (pig) : TMPRSS6 (transmembrane serine protease 6)
Chlorocebus sabaeus (African green monkey) : TMPRSS6 (transmembrane serine protease 6)
Heterocephalus glaber (naked mole-rat) : Tmprss6 (transmembrane serine protease 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2237,065,436 - 37,109,713 (-)EnsemblGRCh38hg38GRCh38
GRCh382237,065,436 - 37,110,625 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372237,461,476 - 37,499,693 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,791,425 - 35,829,639 (-)NCBINCBI36hg18NCBI36
Build 342235,785,978 - 35,824,193NCBI
Celera2221,262,809 - 21,300,772 (-)NCBI
Cytogenetic Map22q12.3NCBI
HuRef2220,426,706 - 20,464,791 (-)NCBIHuRef
CHM1_12237,420,980 - 37,464,830 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TMPRSS6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316154
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.