KLK7 (kallikrein related peptidase 7) - Rat Genome Database

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Gene: KLK7 (kallikrein related peptidase 7) Homo sapiens
Analyze
Symbol: KLK7
Name: kallikrein related peptidase 7
RGD ID: 1315024
HGNC Page HGNC:6368
Description: Enables peptidase activity. Involved in positive regulation of antibacterial peptide production. Located in epidermal lamellar body and extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: hK7; hSCCE; kallikrein 7 (chymotryptic, stratum corneum); kallikrein-7; kallikrein-related peptidase 7; protease, serine, 6; PRSS6; SCCE; serine protease 6; signal protein; stratum corneum chymotryptic enzyme
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,976,468 - 50,984,064 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1950,976,468 - 50,984,099 (-)EnsemblGRCh38hg38GRCh38
GRCh371951,479,724 - 51,487,320 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,171,541 - 56,178,962 (-)NCBINCBI36Build 36hg18NCBI36
Celera1948,531,233 - 48,539,211 (-)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1947,813,130 - 47,820,053 (-)NCBIHuRef
CHM1_11951,481,810 - 51,489,320 (-)NCBICHM1_1
T2T-CHM13v2.01954,064,867 - 54,072,534 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7794273   PMID:8034709   PMID:8393902   PMID:8889549   PMID:10974542   PMID:11054574   PMID:12477932   PMID:12738725   PMID:14691584   PMID:14972646   PMID:15140227   PMID:15191543  
PMID:15297163   PMID:15489334   PMID:15675955   PMID:15766562   PMID:16344560   PMID:16628198   PMID:16800723   PMID:16800724   PMID:17012259   PMID:17275179   PMID:17909180   PMID:17989887  
PMID:18163887   PMID:18325919   PMID:18329042   PMID:18343220   PMID:18774391   PMID:18953252   PMID:18976018   PMID:19085836   PMID:19091121   PMID:19118981   PMID:19350120   PMID:19423540  
PMID:19453546   PMID:19558318   PMID:19921697   PMID:20090765   PMID:20332224   PMID:20406964   PMID:20424135   PMID:20438785   PMID:20544292   PMID:20665732   PMID:20944116   PMID:21168996  
PMID:21520985   PMID:21548205   PMID:21616098   PMID:21832049   PMID:21868565   PMID:21873635   PMID:22521249   PMID:22573795   PMID:22825846   PMID:23224034   PMID:23413953   PMID:23495698  
PMID:25153388   PMID:25182706   PMID:25448018   PMID:25477184   PMID:25640309   PMID:26022646   PMID:26032414   PMID:26186194   PMID:26231762   PMID:27279059   PMID:27478344   PMID:27769847  
PMID:28479159   PMID:28514442   PMID:28636767   PMID:29229980   PMID:29319165   PMID:29498930   PMID:29779317   PMID:30644845   PMID:30705123   PMID:31180492   PMID:31883963   PMID:32323843  
PMID:33276948   PMID:33588911   PMID:33961781   PMID:34525904   PMID:36543142  


Genomics

Comparative Map Data
KLK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,976,468 - 50,984,064 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1950,976,468 - 50,984,099 (-)EnsemblGRCh38hg38GRCh38
GRCh371951,479,724 - 51,487,320 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,171,541 - 56,178,962 (-)NCBINCBI36Build 36hg18NCBI36
Celera1948,531,233 - 48,539,211 (-)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1947,813,130 - 47,820,053 (-)NCBIHuRef
CHM1_11951,481,810 - 51,489,320 (-)NCBICHM1_1
T2T-CHM13v2.01954,064,867 - 54,072,534 (-)NCBIT2T-CHM13v2.0
Klk7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,460,718 - 43,465,811 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,460,718 - 43,465,783 (+)EnsemblGRCm39 Ensembl
GRCm38743,811,294 - 43,816,387 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl743,811,294 - 43,816,359 (+)EnsemblGRCm38mm10GRCm38
MGSCv37751,066,814 - 51,071,729 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36743,679,486 - 43,684,401 (+)NCBIMGSCv36mm8
Celera739,278,059 - 39,282,925 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.27NCBI
Klk7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,403,206 - 103,407,907 (+)NCBIGRCr8
mRatBN7.2194,267,170 - 94,271,361 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,266,605 - 94,271,332 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,652,577 - 99,656,768 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,125,248 - 108,129,439 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,414,839 - 101,419,040 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,749,991 - 99,754,723 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,749,936 - 99,754,435 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01100,818,808 - 100,823,452 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,243,421 - 94,246,711 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1194,320,659 - 94,323,995 (+)NCBI
Celera188,535,508 - 88,538,798 (+)NCBICelera
Cytogenetic Map1q22NCBI
Klk7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555581,490,120 - 1,494,993 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555581,490,884 - 1,494,843 (+)NCBIChiLan1.0ChiLan1.0
KLK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22057,046,646 - 57,053,670 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11958,967,738 - 58,974,995 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01947,944,072 - 47,951,506 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KLK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,891,206 - 105,895,441 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,464,096 - 105,467,219 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,399,900 - 106,404,253 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1106,400,435 - 106,403,750 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11106,071,917 - 106,075,040 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,713,325 - 105,716,448 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,508,823 - 106,511,946 (+)NCBIUU_Cfam_GSD_1.0
Klk7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,761,330 - 22,766,037 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889637,996 - 641,126 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936889637,526 - 641,126 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,644,628 - 55,648,961 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,644,627 - 55,649,000 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KLK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1643,998,661 - 44,021,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607324,022,871 - 24,029,762 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klk7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248323,775,252 - 3,778,432 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248323,774,837 - 3,778,646 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KLK7
27 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.33-13.43(chr19:50191219-58535818)x3 copy number gain See cases [RCV000050883] Chr19:50191219..58535818 [GRCh38]
Chr19:50694476..59047185 [GRCh37]
Chr19:55386288..63738997 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:49907832-58557889)x3 copy number gain See cases [RCV000052925] Chr19:49907832..58557889 [GRCh38]
Chr19:50411089..59069256 [GRCh37]
Chr19:55102901..63761068 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50152520-58581203)x3 copy number gain See cases [RCV000135843] Chr19:50152520..58581203 [GRCh38]
Chr19:50655777..59092570 [GRCh37]
Chr19:55347589..63784382 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:50489390-59095359)x3 copy number gain See cases [RCV000445925] Chr19:50489390..59095359 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:50740074-59097160)x3 copy number gain not provided [RCV000740208] Chr19:50740074..59097160 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
NM_005046.4(KLK7):c.624G>T (p.Pro208=) single nucleotide variant not provided [RCV000962711] Chr19:50977674 [GRCh38]
Chr19:51480930 [GRCh37]
Chr19:19q13.41		 benign
NM_005046.4(KLK7):c.678C>T (p.Cys226=) single nucleotide variant not provided [RCV000966620] Chr19:50977620 [GRCh38]
Chr19:51480876 [GRCh37]
Chr19:19q13.41		 benign
NM_005046.4(KLK7):c.441C>T (p.Ser147=) single nucleotide variant not provided [RCV000951348] Chr19:50980268 [GRCh38]
Chr19:51483524 [GRCh37]
Chr19:19q13.41		 benign
NM_005046.4(KLK7):c.725C>T (p.Thr242Ile) single nucleotide variant not provided [RCV000955570] Chr19:50977573 [GRCh38]
Chr19:51480829 [GRCh37]
Chr19:19q13.41		 benign
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42		 pathogenic
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871) copy number gain not provided [RCV001249294] Chr19:47939842..54626871 [GRCh37]
Chr19:19q13.32-13.42		 not provided
GRCh37/hg19 19q13.33-13.41(chr19:50469730-51916485)x3 copy number gain not provided [RCV001007055] Chr19:50469730..51916485 [GRCh37]
Chr19:19q13.33-13.41		 uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3 copy number gain not provided [RCV001259944] Chr19:48463931..57095254 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19q13.33-13.41(chr19:49911081-53127438) copy number gain not specified [RCV002052689] Chr19:49911081..53127438 [GRCh37]
Chr19:19q13.33-13.41		 likely pathogenic
NM_005046.4(KLK7):c.341T>C (p.Met114Thr) single nucleotide variant Inborn genetic diseases [RCV003256906] Chr19:50980368 [GRCh38]
Chr19:51483624 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.261C>G (p.Asp87Glu) single nucleotide variant Inborn genetic diseases [RCV002682075] Chr19:50980448 [GRCh38]
Chr19:51483704 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.127T>C (p.Trp43Arg) single nucleotide variant Inborn genetic diseases [RCV002754352] Chr19:50981861 [GRCh38]
Chr19:51485117 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.493T>A (p.Cys165Ser) single nucleotide variant Inborn genetic diseases [RCV002777552] Chr19:50979901 [GRCh38]
Chr19:51483157 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.515C>G (p.Ser172Cys) single nucleotide variant Inborn genetic diseases [RCV002837037] Chr19:50979879 [GRCh38]
Chr19:51483135 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.232G>A (p.Val78Met) single nucleotide variant Inborn genetic diseases [RCV002694615] Chr19:50980477 [GRCh38]
Chr19:51483733 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.595A>C (p.Asn199His) single nucleotide variant Inborn genetic diseases [RCV002789257] Chr19:50979799 [GRCh38]
Chr19:51483055 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.26T>A (p.Leu9Gln) single nucleotide variant Inborn genetic diseases [RCV002850387] Chr19:50982374 [GRCh38]
Chr19:51485630 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.458C>T (p.Thr153Met) single nucleotide variant Inborn genetic diseases [RCV003004772] Chr19:50980251 [GRCh38]
Chr19:51483507 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.533A>G (p.Lys178Arg) single nucleotide variant Inborn genetic diseases [RCV002764415] Chr19:50979861 [GRCh38]
Chr19:51483117 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.415C>T (p.Pro139Ser) single nucleotide variant Inborn genetic diseases [RCV002649039] Chr19:50980294 [GRCh38]
Chr19:51483550 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.151A>C (p.Asn51His) single nucleotide variant Inborn genetic diseases [RCV003212948] Chr19:50981837 [GRCh38]
Chr19:51485093 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.275G>C (p.Arg92Thr) single nucleotide variant Inborn genetic diseases [RCV003208066] Chr19:50980434 [GRCh38]
Chr19:51483690 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.328G>A (p.Val110Ile) single nucleotide variant Inborn genetic diseases [RCV003218599] Chr19:50980381 [GRCh38]
Chr19:51483637 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.720G>C (p.Lys240Asn) single nucleotide variant Inborn genetic diseases [RCV003194232] Chr19:50977578 [GRCh38]
Chr19:51480834 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.307G>A (p.Gly103Ser) single nucleotide variant Inborn genetic diseases [RCV003261845] Chr19:50980402 [GRCh38]
Chr19:51483658 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_005046.4(KLK7):c.468T>A (p.Asp156Glu) single nucleotide variant Inborn genetic diseases [RCV003370780] Chr19:50980241 [GRCh38]
Chr19:51483497 [GRCh37]
Chr19:19q13.41		 uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:49625130-57647352)x3 copy number gain not provided [RCV003485200] Chr19:49625130..57647352 [GRCh37]
Chr19:19q13.33-13.43		 likely pathogenic
GRCh37/hg19 19q13.33-13.41(chr19:48905537-51614930)x3 copy number gain not specified [RCV003986127] Chr19:48905537..51614930 [GRCh37]
Chr19:19q13.33-13.41		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1915
Count of miRNA genes:787
Interacting mature miRNAs:864
Transcripts:ENST00000304045, ENST00000336317, ENST00000391807, ENST00000593904, ENST00000595638, ENST00000595820, ENST00000597707
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D19S1082  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371951,480,648 - 51,480,751UniSTSGRCh37
Build 361956,172,460 - 56,172,563RGDNCBI36
Celera1948,532,152 - 48,532,251RGD
Cytogenetic Map19q13.41UniSTS
HuRef1947,814,043 - 47,814,142UniSTS
KLK7_7860  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371951,480,402 - 51,480,865UniSTSGRCh37
Build 361956,172,214 - 56,172,677RGDNCBI36
Celera1948,531,906 - 48,532,365RGD
HuRef1947,813,797 - 47,814,256UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 31
Medium 56 1 24 110 2 1339 7 551 55 205 58 117 194 724
Low 439 232 263 68 222 17 902 293 1805 111 535 454 56 1 299 672 4 2
Below cutoff 1742 2300 1090 187 920 187 1791 1641 1285 95 602 955 1 619 1213 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001207053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_139277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A42048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AA101043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC011483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF166330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF243527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF332583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF411214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF411215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI049783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY601109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY646152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ785390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA243628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA307925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ018784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF963189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF963190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF963191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF963192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF963193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX519464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX519465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L33404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN510775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN510776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000304045   ⟹   ENSP00000304791
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1950,976,482 - 50,984,099 (-)Ensembl
RefSeq Acc Id: ENST00000391807   ⟹   ENSP00000375683
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1950,976,488 - 50,983,815 (-)Ensembl
RefSeq Acc Id: ENST00000593904   ⟹   ENSP00000470084
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1950,980,286 - 50,983,914 (-)Ensembl
RefSeq Acc Id: ENST00000595638
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1950,982,095 - 50,984,064 (-)Ensembl
RefSeq Acc Id: ENST00000595820   ⟹   ENSP00000470538
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1950,976,468 - 50,983,917 (-)Ensembl
RefSeq Acc Id: ENST00000597707   ⟹   ENSP00000469950
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1950,977,359 - 50,984,038 (-)Ensembl
RefSeq Acc Id: NM_001207053   ⟹   NP_001193982
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381950,976,468 - 50,983,917 (-)NCBI
GRCh371951,479,735 - 51,487,320 (-)ENTREZGENE
HuRef1947,813,130 - 47,820,053 (-)ENTREZGENE
CHM1_11951,481,810 - 51,489,320 (-)NCBI
T2T-CHM13v2.01954,064,867 - 54,072,387 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001243126   ⟹   NP_001230055
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381950,976,479 - 50,984,064 (-)NCBI
GRCh371951,479,735 - 51,487,320 (-)NCBI
HuRef1947,813,130 - 47,820,053 (-)NCBI
CHM1_11951,481,810 - 51,489,320 (-)NCBI
T2T-CHM13v2.01954,064,878 - 54,072,534 (-)NCBI
Sequence:
RefSeq Acc Id: NM_005046   ⟹   NP_005037
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381950,976,468 - 50,983,917 (-)NCBI
GRCh371951,479,735 - 51,487,320 (-)ENTREZGENE
Build 361956,171,541 - 56,178,962 (-)NCBI Archive
HuRef1947,813,130 - 47,820,053 (-)ENTREZGENE
CHM1_11951,481,810 - 51,489,320 (-)NCBI
T2T-CHM13v2.01954,064,867 - 54,072,387 (-)NCBI
Sequence:
RefSeq Acc Id: NM_139277   ⟹   NP_644806
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381950,976,479 - 50,983,815 (-)NCBI
GRCh371951,479,735 - 51,487,320 (-)ENTREZGENE
Build 361956,171,541 - 56,178,883 (-)NCBI Archive
HuRef1947,813,130 - 47,820,053 (-)ENTREZGENE
CHM1_11951,481,810 - 51,489,071 (-)NCBI
T2T-CHM13v2.01954,064,878 - 54,072,285 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001193982 (Get FASTA)   NCBI Sequence Viewer  
  NP_001230055 (Get FASTA)   NCBI Sequence Viewer  
  NP_005037 (Get FASTA)   NCBI Sequence Viewer  
  NP_644806 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC37551 (Get FASTA)   NCBI Sequence Viewer  
  AAD49718 (Get FASTA)   NCBI Sequence Viewer  
  AAG33360 (Get FASTA)   NCBI Sequence Viewer  
  AAH32005 (Get FASTA)   NCBI Sequence Viewer  
  AAK69624 (Get FASTA)   NCBI Sequence Viewer  
  AAN03662 (Get FASTA)   NCBI Sequence Viewer  
  AAN03663 (Get FASTA)   NCBI Sequence Viewer  
  AAT66047 (Get FASTA)   NCBI Sequence Viewer  
  AAU04540 (Get FASTA)   NCBI Sequence Viewer  
  AAY97797 (Get FASTA)   NCBI Sequence Viewer  
  AHN52223 (Get FASTA)   NCBI Sequence Viewer  
  AHN52224 (Get FASTA)   NCBI Sequence Viewer  
  AQM73456 (Get FASTA)   NCBI Sequence Viewer  
  AQM73457 (Get FASTA)   NCBI Sequence Viewer  
  BAF82349 (Get FASTA)   NCBI Sequence Viewer  
  BAG58291 (Get FASTA)   NCBI Sequence Viewer  
  CAA02644 (Get FASTA)   NCBI Sequence Viewer  
  CAG17626 (Get FASTA)   NCBI Sequence Viewer  
  EAW71958 (Get FASTA)   NCBI Sequence Viewer  
  EAW71959 (Get FASTA)   NCBI Sequence Viewer  
  EAW71960 (Get FASTA)   NCBI Sequence Viewer  
  EAW71961 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000304791.2
  ENSP00000375683
  ENSP00000375683.1
  ENSP00000469950
  ENSP00000469950.1
  ENSP00000470084.1
  ENSP00000470538
  ENSP00000470538.1
GenBank Protein P49862 (Get FASTA)   NCBI Sequence Viewer  
  QIB02117 (Get FASTA)   NCBI Sequence Viewer  
  QIB02118 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001193982   ⟸   NM_001207053
- Peptide Label: isoform 2
- UniProtKB: P49862 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_005037   ⟸   NM_005046
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q8N5N9 (UniProtKB/Swiss-Prot),   A8K0U5 (UniProtKB/Swiss-Prot),   Q8NFV7 (UniProtKB/Swiss-Prot),   P49862 (UniProtKB/Swiss-Prot),   A0A024R4H6 (UniProtKB/TrEMBL),   B8K1J4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_644806   ⟸   NM_139277
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q8N5N9 (UniProtKB/Swiss-Prot),   A8K0U5 (UniProtKB/Swiss-Prot),   Q8NFV7 (UniProtKB/Swiss-Prot),   P49862 (UniProtKB/Swiss-Prot),   A0A024R4H6 (UniProtKB/TrEMBL),   B8K1J4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230055   ⟸   NM_001243126
- Peptide Label: isoform 3
- UniProtKB: P49862 (UniProtKB/Swiss-Prot),   B4DHX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000470538   ⟸   ENST00000595820
RefSeq Acc Id: ENSP00000469950   ⟸   ENST00000597707
RefSeq Acc Id: ENSP00000375683   ⟸   ENST00000391807
RefSeq Acc Id: ENSP00000304791   ⟸   ENST00000304045
RefSeq Acc Id: ENSP00000470084   ⟸   ENST00000593904
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49862-F1-model_v2 AlphaFold P49862 1-253 view protein structure

Promoters
RGD ID:13205315
Promoter ID:EPDNEW_H26238
Type:initiation region
Name:KLK7_2
Description:kallikrein related peptidase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26239  EPDNEW_H26240  EPDNEW_H26241  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381950,983,915 - 50,983,975EPDNEW
RGD ID:13205317
Promoter ID:EPDNEW_H26239
Type:initiation region
Name:KLK7_3
Description:kallikrein related peptidase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26238  EPDNEW_H26240  EPDNEW_H26241  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381950,984,038 - 50,984,098EPDNEW
RGD ID:13205319
Promoter ID:EPDNEW_H26240
Type:initiation region
Name:KLK7_4
Description:kallikrein related peptidase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26238  EPDNEW_H26239  EPDNEW_H26241  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381950,984,202 - 50,984,262EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6368 AgrOrtholog
COSMIC KLK7 COSMIC
Ensembl Genes ENSG00000169035 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000304045.6 UniProtKB/TrEMBL
  ENST00000391807 ENTREZGENE
  ENST00000391807.5 UniProtKB/Swiss-Prot
  ENST00000593904.1 UniProtKB/TrEMBL
  ENST00000595820 ENTREZGENE
  ENST00000595820.6 UniProtKB/Swiss-Prot
  ENST00000597707 ENTREZGENE
  ENST00000597707.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000169035 GTEx
HGNC ID HGNC:6368 ENTREZGENE
Human Proteome Map KLK7 Human Proteome Map
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5650 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5650 ENTREZGENE
OMIM 604438 OMIM
PANTHER KALLIKREIN-7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  RIKEN CDNA 2210010C04 GENE UniProtKB/TrEMBL
  TRYPSIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30157 PharmGKB
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R4H6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2H4GDB2_HUMAN UniProtKB/TrEMBL
  A0A2H4GDB6_HUMAN UniProtKB/TrEMBL
  A8K0U5 ENTREZGENE
  B4DHX9 ENTREZGENE, UniProtKB/TrEMBL
  B8K1J4 ENTREZGENE, UniProtKB/TrEMBL
  KLK7_HUMAN UniProtKB/Swiss-Prot
  M0QYU8_HUMAN UniProtKB/TrEMBL
  P49862 ENTREZGENE
  Q6DTY1_HUMAN UniProtKB/TrEMBL
  Q8N5N9 ENTREZGENE
  Q8NFV7 ENTREZGENE
  X2J289_HUMAN UniProtKB/TrEMBL
  X2J4X7_HUMAN UniProtKB/TrEMBL
UniProt Secondary A8K0U5 UniProtKB/Swiss-Prot
  Q8N5N9 UniProtKB/Swiss-Prot
  Q8NFV7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 KLK7  kallikrein related peptidase 7  KLK7  kallikrein-related peptidase 7  Symbol and/or name change 5135510 APPROVED