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Gene: ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif 5) Homo sapiens
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Symbol: ADAMTS5
Name: ADAM metallopeptidase with thrombospondin type 1 motif 5
RGD ID: 1343923
Description: Exhibits peptidase activity. Predicted to be involved in extracellular matrix organization and negative regulation of cold-induced thermogenesis. Predicted to localize to extracellular matrix. Implicated in osteoarthritis. Biomarker of osteoarthritis and rheumatoid arthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: a disintegrin and metalloproteinase with thrombospondin motifs 11; A disintegrin and metalloproteinase with thrombospondin motifs 5; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2); ADAM-TS 11; ADAM-TS 5; ADAM-TS5; ADAMTS-11; ADAMTS-5; ADAMTS11; ADMP-2; aggrecanase-2; FLJ36738
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2126,917,922 - 26,967,088 (-)EnsemblGRCh38hg38GRCh38
GRCh382126,917,922 - 26,967,758 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372128,290,231 - 28,339,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,212,112 - 27,260,703 (-)NCBINCBI36hg18NCBI36
Build 342127,215,656 - 27,260,703NCBI
Celera2113,473,563 - 13,522,743 (-)NCBI
Cytogenetic Map21q21.3NCBI
HuRef2113,695,092 - 13,744,202 (-)NCBIHuRef
CHM1_12127,852,147 - 27,901,362 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ADAMTS5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1343923
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.