TPSAB1 (tryptase alpha/beta 1) - Rat Genome Database

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Gene: TPSAB1 (tryptase alpha/beta 1) Homo sapiens
Analyze
Symbol: TPSAB1
Name: tryptase alpha/beta 1
RGD ID: 1605426
HGNC Page HGNC:12019
Description: Enables identical protein binding activity. Involved in extracellular matrix disassembly and proteolysis. Located in peptidase complex. Colocalizes with collagen-containing extracellular matrix.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: mast cell alpha II tryptase; mast cell beta I tryptase; mast cell tryptase; MGC104064; TPS1; TPS2; TPSB1; TPSB2; tryptase alpha II; tryptase alpha-1; tryptase alpha/beta-1; tryptase beta 1; tryptase beta I; tryptase beta-1; Tryptase beta-2; tryptase I; Tryptase II; tryptase, alpha; tryptase-1; Tryptase-2; tryptase-I; tryptase-III
RGD Orthologs
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,240,705 - 1,242,554 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl161,240,379 - 1,242,554 (+)EnsemblGRCh38hg38GRCh38
GRCh37161,290,706 - 1,292,555 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,230,679 - 1,232,556 (+)NCBINCBI36Build 36hg18NCBI36
Celera161,494,229 - 1,494,587 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,211,394 - 1,224,921 (-)NCBIHuRef
CHM1_1161,289,978 - 1,291,845 (+)NCBICHM1_1
T2T-CHM13v2.0161,259,422 - 1,261,271 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
Seizure  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2187193   PMID:2203827   PMID:2677049   PMID:3161948   PMID:7009736   PMID:7730649   PMID:8434231   PMID:8598474   PMID:8675637   PMID:9077541   PMID:9300715   PMID:9485375  
PMID:9521329   PMID:9920877   PMID:10391906   PMID:10500112   PMID:10514402   PMID:10708850   PMID:10708866   PMID:10843716   PMID:10898108   PMID:11157797   PMID:11325588   PMID:11533057  
PMID:11568008   PMID:11792624   PMID:11876641   PMID:11906611   PMID:12100045   PMID:12217407   PMID:12391231   PMID:12397176   PMID:12477932   PMID:12742661   PMID:12874242   PMID:15567416  
PMID:15638376   PMID:16027150   PMID:16414069   PMID:16517749   PMID:17146627   PMID:17205215   PMID:17449330   PMID:17474147   PMID:17635650   PMID:17655281   PMID:18079491   PMID:18359288  
PMID:18790994   PMID:18854315   PMID:19100407   PMID:19250736   PMID:19535787   PMID:19625657   PMID:19697770   PMID:19748655   PMID:20087660   PMID:20540319   PMID:20551380   PMID:20718781  
PMID:21493897   PMID:21707711   PMID:21791437   PMID:21873635   PMID:22046132   PMID:22102069   PMID:22194960   PMID:22363824   PMID:22613992   PMID:23018683   PMID:23330964   PMID:23559352  
PMID:23991686   PMID:24054365   PMID:24155887   PMID:24237068   PMID:24372627   PMID:24507159   PMID:24565497   PMID:24726923   PMID:24806698   PMID:24830464   PMID:24915568   PMID:25797204  
PMID:25957593   PMID:26044856   PMID:26089601   PMID:27068509   PMID:27288661   PMID:27545065   PMID:27749843   PMID:28049209   PMID:28319085   PMID:28514442   PMID:29661938   PMID:30463901  
PMID:30641266   PMID:31209239   PMID:31337736   PMID:32709152   PMID:32717252   PMID:32777817  


Genomics

Comparative Map Data
TPSAB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,240,705 - 1,242,554 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl161,240,379 - 1,242,554 (+)EnsemblGRCh38hg38GRCh38
GRCh37161,290,706 - 1,292,555 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,230,679 - 1,232,556 (+)NCBINCBI36Build 36hg18NCBI36
Celera161,494,229 - 1,494,587 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,211,394 - 1,224,921 (-)NCBIHuRef
CHM1_1161,289,978 - 1,291,845 (+)NCBICHM1_1
T2T-CHM13v2.0161,259,422 - 1,261,271 (-)NCBIT2T-CHM13v2.0
Tpsab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,562,219 - 25,564,536 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,562,219 - 25,564,536 (-)EnsemblGRCm39 Ensembl
GRCm381725,343,245 - 25,345,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,343,245 - 25,345,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv371725,480,364 - 25,482,423 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361725,480,190 - 25,482,472 (-)NCBIMGSCv36mm8
Celera1725,871,535 - 25,873,843 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Tpsab1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21014,360,396 - 14,362,811 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,360,396 - 14,362,811 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,100,758 - 19,103,173 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01018,589,623 - 18,592,038 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01014,088,832 - 14,091,247 (-)NCBIRnor_WKY
Rnor_6.01014,701,253 - 14,703,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,701,253 - 14,703,668 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,519,181 - 14,521,596 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,591,590 - 14,594,005 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11014,591,590 - 14,594,005 (-)NCBI
Celera1014,032,330 - 14,034,745 (-)NCBICelera
Cytogenetic Map10q12NCBI
LOC100049001
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,505,485 - 39,506,909 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,772,274 - 40,773,700 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,850,138 - 39,852,120 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1639,527,216 - 39,528,642 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,499,857 - 39,501,283 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,978,489 - 39,979,916 (+)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in TPSAB1
35 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p13.3-13.13(chr16:23141-11296695)x3 copy number gain See cases [RCV000052367] Chr16:23141..11296695 [GRCh38]
Chr16:73141..11390552 [GRCh37]
Chr16:13141..11298053 [NCBI36]
Chr16:16p13.3-13.13		 pathogenic
GRCh38/hg38 16p13.3(chr16:29941-2560460)x3 copy number gain See cases [RCV000052368] Chr16:29941..2560460 [GRCh38]
Chr16:79941..2610461 [GRCh37]
Chr16:19941..2550462 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:46566-1800860)x3 copy number gain See cases [RCV000052369] Chr16:46566..1800860 [GRCh38]
Chr16:96566..1850861 [GRCh37]
Chr16:36566..1790862 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:46766-3214623)x3 copy number gain See cases [RCV000052370] Chr16:46766..3214623 [GRCh38]
Chr16:96766..3264623 [GRCh37]
Chr16:36766..3204624 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:1221651-2233773)x3 copy number gain See cases [RCV000052373] Chr16:1221651..2233773 [GRCh38]
Chr16:1271651..2283774 [GRCh37]
Chr16:1211652..2223775 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:23141-1773349)x1 copy number loss See cases [RCV000053251] Chr16:23141..1773349 [GRCh38]
Chr16:73141..1823350 [GRCh37]
Chr16:13141..1763351 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:23141-1712523)x1 copy number loss See cases [RCV000053252] Chr16:23141..1712523 [GRCh38]
Chr16:73141..1762524 [GRCh37]
Chr16:13141..1702525 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:46766-1997582)x1 copy number loss See cases [RCV000053253] Chr16:46766..1997582 [GRCh38]
Chr16:96766..2047583 [GRCh37]
Chr16:36766..1987584 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:105429-1499893)x1 copy number loss See cases [RCV000053267] Chr16:105429..1499893 [GRCh38]
Chr16:155427..1549894 [GRCh37]
Chr16:95427..1489895 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3-13.13(chr16:46766-11525516)x3 copy number gain See cases [RCV000133780] Chr16:46766..11525516 [GRCh38]
Chr16:96766..11619372 [GRCh37]
Chr16:36766..11526873 [NCBI36]
Chr16:16p13.3-13.13		 pathogenic
GRCh38/hg38 16p13.3(chr16:46766-1544014)x1 copy number loss See cases [RCV000134917] Chr16:46766..1544014 [GRCh38]
Chr16:96766..1594015 [GRCh37]
Chr16:36766..1534016 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:46766-4247185)x3 copy number gain See cases [RCV000136687] Chr16:46766..4247185 [GRCh38]
Chr16:96766..4297186 [GRCh37]
Chr16:36766..4237187 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:46722-1867327)x1 copy number loss See cases [RCV000137826] Chr16:46722..1867327 [GRCh38]
Chr16:96722..1917328 [GRCh37]
Chr16:36722..1857329 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3-13.12(chr16:43732-13326806)x3 copy number gain See cases [RCV000139166] Chr16:43732..13326806 [GRCh38]
Chr16:93732..13420663 [GRCh37]
Chr16:33732..13328164 [NCBI36]
Chr16:16p13.3-13.12		 pathogenic
GRCh38/hg38 16p13.3(chr16:925267-1324901)x3 copy number gain See cases [RCV000142458] Chr16:925267..1324901 [GRCh38]
Chr16:975267..1374902 [GRCh37]
Chr16:915268..1314903 [NCBI36]
Chr16:16p13.3		 likely pathogenic|uncertain significance
GRCh38/hg38 16p13.3-13.11(chr16:666662-15743104)x3 copy number gain See cases [RCV000143710] Chr16:666662..15743104 [GRCh38]
Chr16:716662..15836961 [GRCh37]
Chr16:656663..15744462 [NCBI36]
Chr16:16p13.3-13.11		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:102839-28327676)x3 copy number gain See cases [RCV000203445] Chr16:102839..28327676 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Ductal breast carcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2		 uncertain significance
GRCh37/hg19 16p13.3-12.3(chr16:1274615-19073133)x3 copy number gain Ductal breast carcinoma [RCV000207326] Chr16:1274615..19073133 [GRCh37]
Chr16:16p13.3-12.3		 uncertain significance
GRCh37/hg19 16p13.3(chr16:88165-1715454)x1 copy number loss See cases [RCV000239415] Chr16:88165..1715454 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:72769-1511716)x1 copy number loss See cases [RCV000240294] Chr16:72769..1511716 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:1278591-1306880)x3 copy number gain See cases [RCV000447023] Chr16:1278591..1306880 [GRCh37]
Chr16:16p13.3		 benign
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-13.2(chr16:78801-9169448) copy number gain See cases [RCV000446555] Chr16:78801..9169448 [GRCh37]
Chr16:16p13.3-13.2		 pathogenic
GRCh37/hg19 16p13.3(chr16:97133-5122974)x3 copy number gain See cases [RCV000445663] Chr16:97133..5122974 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:1278591-1306279)x3 copy number gain See cases [RCV000447716] Chr16:1278591..1306279 [GRCh37]
Chr16:16p13.3		 benign
NC_000016.9:g.(?_1239945)_(1300070_?)del deletion Schizophrenia [RCV000416764] Chr16:1239945..1300070 [GRCh37]
Chr16:1179946..1240071 [NCBI36]
Chr16:16p13.3		 likely pathogenic
GRCh37/hg19 16p13.3(chr16:1279620-1306279)x3 copy number gain See cases [RCV000448751] Chr16:1279620..1306279 [GRCh37]
Chr16:16p13.3		 benign|likely benign
GRCh37/hg19 16p13.3(chr16:643377-3125125)x3 copy number gain See cases [RCV000510815] Chr16:643377..3125125 [GRCh37]
Chr16:16p13.3		 uncertain significance
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-12.2(chr16:85880-22442007)x3 copy number gain See cases [RCV000511360] Chr16:85880..22442007 [GRCh37]
Chr16:16p13.3-12.2		 pathogenic
GRCh37/hg19 16p13.3-13.2(chr16:85880-9883129)x3 copy number gain See cases [RCV000510698] Chr16:85880..9883129 [GRCh37]
Chr16:16p13.3-13.2		 pathogenic
GRCh37/hg19 16p13.3-12.3(chr16:85880-19806921)x3 copy number gain See cases [RCV000512194] Chr16:85880..19806921 [GRCh37]
Chr16:16p13.3-12.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-1498731)x1 copy number loss not provided [RCV000683740] Chr16:85880..1498731 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-1875694)x1 copy number loss not provided [RCV000683741] Chr16:85880..1875694 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-3216551)x3 copy number gain not provided [RCV000683742] Chr16:85880..3216551 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3-13.13(chr16:85880-11209288)x3 copy number gain not provided [RCV000683743] Chr16:85880..11209288 [GRCh37]
Chr16:16p13.3-13.13		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:61451-1593645)x1 copy number loss not provided [RCV000751445] Chr16:61451..1593645 [GRCh37]
Chr16:16p13.3		 pathogenic
NM_003294.4(TPSAB1):c.644C>G (p.Thr215Ser) single nucleotide variant not provided [RCV001541480] Chr16:1241971 [GRCh38]
Chr16:1291972 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.734G>A (p.Gly245Asp) single nucleotide variant not provided [RCV001707391] Chr16:1242146 [GRCh38]
Chr16:1292147 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.663+30C>A single nucleotide variant not provided [RCV001645601] Chr16:1242020 [GRCh38]
Chr16:1292021 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.711G>A (p.Leu237=) single nucleotide variant not provided [RCV001669372] Chr16:1242123 [GRCh38]
Chr16:1292124 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.647G>A (p.Arg216Gln) single nucleotide variant not provided [RCV001692680] Chr16:1241974 [GRCh38]
Chr16:1291975 [GRCh37]
Chr16:16p13.3		 benign
GRCh37/hg19 16p13.3(chr16:109978-4316797) copy number gain Chromosome 16p13.3 duplication syndrome [RCV000767731] Chr16:109978..4316797 [GRCh37]
Chr16:16p13.3		 pathogenic
NC_000016.9:g.(?_624055)_(2148005_?)del deletion Tuberous sclerosis 2 [RCV001033183] Chr16:624055..2148005 [GRCh37]
Chr16:16p13.3		 pathogenic
NC_000016.9:g.(?_624055)_(2115656_?)del deletion Tuberous sclerosis 2 [RCV000811345] Chr16:624055..2115656 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:1134638-1295079)x4 copy number gain not provided [RCV000848315] Chr16:1134638..1295079 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3(chr16:85880-2053328)x1 copy number loss not provided [RCV000849039] Chr16:85880..2053328 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-1468459)x1 copy number loss not provided [RCV000848130] Chr16:85880..1468459 [GRCh37]
Chr16:16p13.3		 pathogenic
NM_003294.4(TPSAB1):c.233+30G>C single nucleotide variant not provided [RCV001663146] Chr16:1241354 [GRCh38]
Chr16:1291355 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.663+28G>C single nucleotide variant not provided [RCV001645225] Chr16:1242018 [GRCh38]
Chr16:1292019 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.663+37C>T single nucleotide variant not provided [RCV001660800] Chr16:1242027 [GRCh38]
Chr16:1292028 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.661C>A (p.Gln221Lys) single nucleotide variant not provided [RCV001671960] Chr16:1241988 [GRCh38]
Chr16:1291989 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.396C>G (p.Asn132Lys) single nucleotide variant not provided [RCV001676226] Chr16:1241596 [GRCh38]
Chr16:1291597 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.233+12G>A single nucleotide variant not provided [RCV001620522] Chr16:1241336 [GRCh38]
Chr16:1291337 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.253G>A (p.Ala85Thr) single nucleotide variant not provided [RCV001654952] Chr16:1241453 [GRCh38]
Chr16:1291454 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.484G>A (p.Asp162Asn) single nucleotide variant not provided [RCV001656431] Chr16:1241684 [GRCh38]
Chr16:1291685 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.421A>G (p.Thr141Ala) single nucleotide variant not provided [RCV001596702] Chr16:1241621 [GRCh38]
Chr16:1291622 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.664-38A>G single nucleotide variant not provided [RCV001656503] Chr16:1242038 [GRCh38]
Chr16:1292039 [GRCh37]
Chr16:16p13.3		 benign
GRCh37/hg19 16p13.3(chr16:1129080-2021055)x3 copy number gain not provided [RCV002473769] Chr16:1129080..2021055 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_003294.4(TPSAB1):c.664-26C>T single nucleotide variant not provided [RCV001688024] Chr16:1242050 [GRCh38]
Chr16:1292051 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.663+12C>G single nucleotide variant not provided [RCV001684687] Chr16:1242002 [GRCh38]
Chr16:1292003 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.153C>T (p.His51=) single nucleotide variant not provided [RCV001638777] Chr16:1241244 [GRCh38]
Chr16:1291245 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.1-105C>A single nucleotide variant not provided [RCV001684941] Chr16:1240834 [GRCh38]
Chr16:1290835 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.672C>T (p.Ser224=) single nucleotide variant not provided [RCV001651999] Chr16:1242084 [GRCh38]
Chr16:1292085 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.62-40C>G single nucleotide variant not provided [RCV001677621] Chr16:1241113 [GRCh38]
Chr16:1291114 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.226G>C (p.Val76Leu) single nucleotide variant not provided [RCV001715245] Chr16:1241317 [GRCh38]
Chr16:1291318 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.*16G>T single nucleotide variant not provided [RCV001598270] Chr16:1242256 [GRCh38]
Chr16:1292257 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.83G>A (p.Arg28Gln) single nucleotide variant not provided [RCV001617464] Chr16:1241174 [GRCh38]
Chr16:1291175 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.62-27C>T single nucleotide variant not provided [RCV001674440] Chr16:1241126 [GRCh38]
Chr16:1291127 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.503G>C (p.Arg168Pro) single nucleotide variant not provided [RCV001684406] Chr16:1241830 [GRCh38]
Chr16:1291831 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.216A>G (p.Ala72=) single nucleotide variant not provided [RCV001649198] Chr16:1241307 [GRCh38]
Chr16:1291308 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.*13T>G single nucleotide variant not provided [RCV001648075] Chr16:1242253 [GRCh38]
Chr16:1292254 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.664-35C>T single nucleotide variant not provided [RCV001668982] Chr16:1242041 [GRCh38]
Chr16:1292042 [GRCh37]
Chr16:16p13.3		 benign
NC_000016.9:g.(?_1203718)_(2185710_?)del deletion Tuberous sclerosis 2 [RCV001033886] Chr16:1203718..2185710 [GRCh37]
Chr16:16p13.3		 pathogenic
NC_000016.9:g.(?_624055)_(2550979_?)dup duplication Idiopathic generalized epilepsy [RCV001033790] Chr16:624055..2550979 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3(chr16:84485-5251013)x3 copy number gain not provided [RCV001537890] Chr16:84485..5251013 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:1233996-1509217)x3 copy number gain not provided [RCV001259760] Chr16:1233996..1509217 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3(chr16:85880-5249457)x3 copy number gain not provided [RCV001259749] Chr16:85880..5249457 [GRCh37]
Chr16:16p13.3		 pathogenic
NM_003294.4(TPSAB1):c.663+21G>C single nucleotide variant not provided [RCV001538491] Chr16:1242011 [GRCh38]
Chr16:1292012 [GRCh37]
Chr16:16p13.3		 benign
NC_000016.9:g.(?_624055)_(2153916_?)dup duplication Epilepsy [RCV001344085]|Idiopathic generalized epilepsy [RCV001316565] Chr16:624055..2153916 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_003294.4(TPSAB1):c.61+75T>C single nucleotide variant not provided [RCV001688213] Chr16:1241074 [GRCh38]
Chr16:1291075 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.657A>C (p.Ser219=) single nucleotide variant not provided [RCV001691840] Chr16:1241984 [GRCh38]
Chr16:1291985 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.664-38A>C single nucleotide variant not provided [RCV001696445] Chr16:1242038 [GRCh38]
Chr16:1292039 [GRCh37]
Chr16:16p13.3		 benign
NM_003294.4(TPSAB1):c.663+35A>C single nucleotide variant not provided [RCV001670407] Chr16:1242025 [GRCh38]
Chr16:1292026 [GRCh37]
Chr16:16p13.3		 benign
GRCh37/hg19 16p13.3(chr16:85880-1468828) copy number loss not specified [RCV002052500] Chr16:85880..1468828 [GRCh37]
Chr16:16p13.3		 pathogenic
NC_000016.9:g.(?_256302)_(5971108_?)dup duplication Familial Mediterranean fever [RCV001877532]|Fanconi anemia [RCV001877533]|not provided [RCV001877531] Chr16:256302..5971108 [GRCh37]
Chr16:16p13.3		 uncertain significance
NC_000016.9:g.(?_256302)_(4852572_?)dup duplication Epilepsy [RCV003113403]|Idiopathic generalized epilepsy [RCV003109446]|Saldino-Mainzer syndrome [RCV003113404] Chr16:256302..4852572 [GRCh37]
Chr16:16p13.3		 uncertain significance
NC_000016.9:g.(?_256302)_(1843653_?)del deletion Idiopathic generalized epilepsy [RCV003109815] Chr16:256302..1843653 [GRCh37]
Chr16:16p13.3		 uncertain significance
NC_000016.9:g.(?_256302)_(1657267_?)del deletion Saldino-Mainzer syndrome [RCV003116765]|not provided [RCV003116766] Chr16:256302..1657267 [GRCh37]
Chr16:16p13.3		 pathogenic
NC_000016.9:g.(?_256302)_(1918176_?)del deletion not provided [RCV003119703] Chr16:256302..1918176 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3(chr16:111043-6627459)x3 copy number gain See cases [RCV002292215] Chr16:111043..6627459 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85881-1350186)x1 copy number loss not provided [RCV002474576] Chr16:85881..1350186 [GRCh37]
Chr16:16p13.3		 pathogenic
NM_003294.4(TPSAB1):c.98G>A (p.Gly33Glu) single nucleotide variant Inborn genetic diseases [RCV002683285] Chr16:1241189 [GRCh38]
Chr16:1291190 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_003294.4(TPSAB1):c.547A>G (p.Met183Val) single nucleotide variant Inborn genetic diseases [RCV002991151] Chr16:1241874 [GRCh38]
Chr16:1291875 [GRCh37]
Chr16:16p13.3		 likely benign
NM_003294.4(TPSAB1):c.356G>A (p.Gly119Glu) single nucleotide variant Inborn genetic diseases [RCV002732492] Chr16:1241556 [GRCh38]
Chr16:1291557 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_003294.4(TPSAB1):c.353T>C (p.Ile118Thr) single nucleotide variant Inborn genetic diseases [RCV002950965] Chr16:1241553 [GRCh38]
Chr16:1291554 [GRCh37]
Chr16:16p13.3		 likely benign
NM_003294.4(TPSAB1):c.346G>A (p.Ala116Thr) single nucleotide variant Inborn genetic diseases [RCV002950964] Chr16:1241546 [GRCh38]
Chr16:1291547 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_003294.4(TPSAB1):c.230G>A (p.Gly77Glu) single nucleotide variant Inborn genetic diseases [RCV002980498] Chr16:1241321 [GRCh38]
Chr16:1291322 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_003294.4(TPSAB1):c.284T>C (p.Leu95Pro) single nucleotide variant Inborn genetic diseases [RCV002916531] Chr16:1241484 [GRCh38]
Chr16:1291485 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_003294.4(TPSAB1):c.344C>T (p.Thr115Ile) single nucleotide variant Inborn genetic diseases [RCV002955880] Chr16:1241544 [GRCh38]
Chr16:1291545 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_003294.4(TPSAB1):c.503G>A (p.Arg168His) single nucleotide variant Inborn genetic diseases [RCV002665785] Chr16:1241830 [GRCh38]
Chr16:1291831 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_003294.4(TPSAB1):c.226G>A (p.Val76Met) single nucleotide variant Inborn genetic diseases [RCV002644629] Chr16:1241317 [GRCh38]
Chr16:1291318 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_003294.4(TPSAB1):c.38C>A (p.Ala13Glu) single nucleotide variant Inborn genetic diseases [RCV002835542] Chr16:1240976 [GRCh38]
Chr16:1290977 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_003294.4(TPSAB1):c.169C>T (p.His57Tyr) single nucleotide variant Inborn genetic diseases [RCV002702947] Chr16:1241260 [GRCh38]
Chr16:1291261 [GRCh37]
Chr16:16p13.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1498
Count of miRNA genes:474
Interacting mature miRNAs:528
Transcripts:ENST00000338844, ENST00000461509, ENST00000561736, ENST00000562432
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH80805  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37161,292,287 - 1,292,534UniSTSGRCh37
Build 36161,232,288 - 1,232,535RGDNCBI36
Celera161,494,250 - 1,494,497RGD
Cytogenetic Map16p13.3UniSTS
HuRef161,211,415 - 1,211,662UniSTS
HuRef161,223,075 - 1,223,322UniSTS
GeneMap99-GB4 RH Map1645.24UniSTS
RH78261  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37161,292,377 - 1,292,521UniSTSGRCh37
GRCh37161,278,370 - 1,278,514UniSTSGRCh37
Build 36161,218,371 - 1,218,515RGDNCBI36
Celera161,494,263 - 1,494,407RGD
Cytogenetic Map16p13.3UniSTS
HuRef161,211,428 - 1,211,572UniSTS
HuRef161,223,088 - 1,223,232UniSTS
GeneMap99-GB4 RH Map1630.02UniSTS
RH78935  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37161,292,538 - 1,292,668UniSTSGRCh37
GRCh37161,278,223 - 1,278,353UniSTSGRCh37
Build 36161,218,224 - 1,218,354RGDNCBI36
Celera161,494,116 - 1,494,246RGD
Cytogenetic Map16p13.3UniSTS
HuRef161,211,281 - 1,211,411UniSTS
HuRef161,222,941 - 1,223,071UniSTS
GeneMap99-GB4 RH Map1630.02UniSTS
RH69115  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37161,292,311 - 1,292,459UniSTSGRCh37
GRCh37161,278,432 - 1,278,580UniSTSGRCh37
Build 36161,218,433 - 1,218,581RGDNCBI36
Celera161,494,325 - 1,494,473RGD
Cytogenetic Map16p13.3UniSTS
HuRef161,211,490 - 1,211,638UniSTS
HuRef161,223,150 - 1,223,298UniSTS
GeneMap99-GB4 RH Map1638.83UniSTS
UniSTS:482183  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37161,290,697 - 1,292,276UniSTSGRCh37
GRCh37161,278,615 - 1,280,195UniSTSGRCh37
HuRef161,223,333 - 1,224,902UniSTS
UniSTS:480727  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37161,290,680 - 1,292,291UniSTSGRCh37


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 2082 714 110 167 277 22 2706 904 553 141 698 716 146 1093 1495
Low 227 1822 1170 364 645 347 1310 1173 405 141 498 531 16 110 1223 1
Below cutoff 24 413 382 68 434 68 165 82 2335 72 135 163 1 1 1 69

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_003293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AE006466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF098328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF099144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF206665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF206666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF206667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ931117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ931118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M33491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M33494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M37488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000338844   ⟹   ENSP00000343577
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl161,240,705 - 1,242,554 (+)Ensembl
RefSeq Acc Id: ENST00000461509   ⟹   ENSP00000418247
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl161,240,724 - 1,242,554 (+)Ensembl
RefSeq Acc Id: ENST00000561736   ⟹   ENSP00000456821
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl161,240,705 - 1,242,516 (+)Ensembl
RefSeq Acc Id: ENST00000562432
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl161,240,938 - 1,242,093 (+)Ensembl
RefSeq Acc Id: ENST00000677899   ⟹   ENSP00000502948
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl161,240,379 - 1,242,554 (+)Ensembl
RefSeq Acc Id: NM_003294   ⟹   NP_003285
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38161,240,705 - 1,242,554 (+)NCBI
GRCh37161,290,678 - 1,292,555 (+)ENTREZGENE
Build 36161,230,679 - 1,232,556 (+)NCBI Archive
CHM1_1161,289,978 - 1,291,845 (+)NCBI
T2T-CHM13v2.0161,259,422 - 1,261,271 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003285   ⟸   NM_003294
- Peptide Label: precursor
- UniProtKB: Q9UQI7 (UniProtKB/Swiss-Prot),   Q9UQI1 (UniProtKB/Swiss-Prot),   Q15661 (UniProtKB/Swiss-Prot),   P20231 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000343577   ⟸   ENST00000338844
RefSeq Acc Id: ENSP00000456821   ⟸   ENST00000561736
RefSeq Acc Id: ENSP00000418247   ⟸   ENST00000461509
RefSeq Acc Id: ENSP00000502948   ⟸   ENST00000677899
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20231-F1-model_v2 AlphaFold P20231 1-275 view protein structure
AF-Q15661-F1-model_v2 AlphaFold Q15661 1-275 view protein structure

Promoters
RGD ID:7230873
Promoter ID:EPDNEW_H21183
Type:initiation region
Name:TPSAB1_1
Description:tryptase alpha/beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21184  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38161,240,706 - 1,240,766EPDNEW
RGD ID:7230877
Promoter ID:EPDNEW_H21184
Type:initiation region
Name:TPSAB1_2
Description:tryptase alpha/beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21183  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38161,241,273 - 1,241,333EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12019 AgrOrtholog
COSMIC TPSAB1 COSMIC
Ensembl Genes ENSG00000172236 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000197253 UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000343577 ENTREZGENE
  ENSP00000343577.3 UniProtKB/Swiss-Prot
  ENSP00000418247 UniProtKB/TrEMBL
  ENSP00000456821 UniProtKB/TrEMBL
  ENSP00000456821.2 UniProtKB/Swiss-Prot
  ENSP00000482743.1 UniProtKB/Swiss-Prot
  ENSP00000502948.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000338844 ENTREZGENE
  ENST00000338844.8 UniProtKB/Swiss-Prot
  ENST00000461509 UniProtKB/TrEMBL
  ENST00000561736 UniProtKB/TrEMBL
  ENST00000561736.2 UniProtKB/Swiss-Prot
  ENST00000606293.5 UniProtKB/Swiss-Prot
  ENST00000677899.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000172236 GTEx
  ENSG00000197253 GTEx
HGNC ID HGNC:12019 ENTREZGENE
Human Proteome Map TPSAB1 Human Proteome Map
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:64499 UniProtKB/Swiss-Prot
  hsa:7177 UniProtKB/Swiss-Prot
NCBI Gene 7177 ENTREZGENE
OMIM 191080 OMIM
PANTHER TRANSMEMBRANE PROTEASE SERINE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPTASE DELTA 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36698 PharmGKB
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0C4DGM1_HUMAN UniProtKB/TrEMBL
  J3QTS8_HUMAN UniProtKB/TrEMBL
  P20231 ENTREZGENE
  Q15661 ENTREZGENE
  Q6B051_HUMAN UniProtKB/TrEMBL
  Q86TM8_HUMAN UniProtKB/TrEMBL
  Q86UA5_HUMAN UniProtKB/TrEMBL
  Q9UQI1 ENTREZGENE
  Q9UQI7 ENTREZGENE
  TRYB1_HUMAN UniProtKB/Swiss-Prot
  TRYB2_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary D2E6R9 UniProtKB/Swiss-Prot
  D2E6S0 UniProtKB/Swiss-Prot
  D2E6S1 UniProtKB/Swiss-Prot
  D2E6S2 UniProtKB/Swiss-Prot
  O95827 UniProtKB/Swiss-Prot
  P15157 UniProtKB/Swiss-Prot
  Q15663 UniProtKB/Swiss-Prot
  Q15664 UniProtKB/Swiss-Prot
  Q6B052 UniProtKB/Swiss-Prot
  Q9H2Y4 UniProtKB/Swiss-Prot
  Q9H2Y5 UniProtKB/Swiss-Prot
  Q9UQI1 UniProtKB/Swiss-Prot
  Q9UQI6 UniProtKB/Swiss-Prot
  Q9UQI7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 TPSAB1  tryptase alpha/beta 1  TPS1  tryptase, alpha  Data Merged 737654 PROVISIONAL
2016-02-18 TPS1  tryptase, alpha    mast cell protease 6  Symbol and/or name change 5135510 APPROVED
2011-08-16 TPSAB1  tryptase alpha/beta 1  TPSAB1  tryptase alpha/beta 1  Symbol and/or name change 5135510 APPROVED