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ONTOLOGY REPORT - ANNOTATIONS

Term:estrogen metabolic process
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Accession:GO:0008210 term browser browse the term
Definition:The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
Synonyms:exact_synonym: estrogen metabolism;   oestrogen metabolic process;   oestrogen metabolism


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estrogen metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chst10 carbohydrate sulfotransferase 10 involved_in ISO
IEA		 (PMID:23269668)
GO_REF:0000107		 RGD
Ensembl		 PMID:23269668 GO_REF:0000107 NCBI chr 9:41,092,805...41,122,737
Ensembl chr 9:41,092,808...41,122,503 		JBrowse link
G Comt catechol-O-methyltransferase IMP RGD PMID:11071850 RGD:2289790 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 involved_in ISO
ISS		 (PMID:11555828), (PMID:12865317), (PMID:14559847)
GO_REF:0000024		 RGD
UniProt		 PMID:11555828 PMID:12865317 PMID:14559847 GO_REF:0000024 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 involved_in ISO
ISS
IEA		 (PMID:11555828), (PMID:12865317)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:11555828 PMID:12865317 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 involved_in IMP
IDA
IEA
ISO		 GO_REF:0000107
(PMID:11555828), (PMID:12865317), (PMID:23821647)
(MGI:5574571|PMID:23821647)		 Ensembl
RGD		 PMID:11555828 PMID:12865317 PMID:23821647 PMID:16893557 PMID:23821647 GO_REF:0000107 MGI:5574571, RGD:1599718, RGD:7829732 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 involved_in ISO (PMID:12865317), (PMID:14559847) RGD PMID:12865317 PMID:14559847
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 involved_in ISO (PMID:12865317) RGD PMID:12865317 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 involved_in ISO (PMID:11555828), (PMID:12865317), (PMID:14559847) RGD PMID:11555828 PMID:12865317 PMID:14559847 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 involved_in ISO (PMID:12865317) RGD PMID:12865317 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 involved_in ISO
IBA
IEA
ISS		 (PMID:12917011)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:12917011 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:21,089,142...21,091,603
Ensembl chr  X:21,089,122...21,109,488 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 involved_in ISO
IEA		 (PMID:7487879)
GO_REF:0000107		 RGD
Ensembl		 PMID:7487879 GO_REF:0000107 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 acts_upstream_of_or_within ISO (PMID:9712896) RGD PMID:9712896 NCBI chr20:4,826,725...4,828,742
Ensembl chr20:4,822,026...4,828,742 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1914283 (PMID:19056881)		 Ensembl
RGD		 PMID:19056881 GO_REF:0000107 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Plekha1 pleckstrin homology domain containing A1 acts_upstream_of_or_within ISO MGI:97530 (PMID:19056881) RGD PMID:19056881 NCBI chr 1:185,427,982...185,479,157
Ensembl chr 1:185,428,048...185,479,156 		JBrowse link
G Schip1 schwannomin interacting protein 1 acts_upstream_of_or_within ISO MGI:97530 (PMID:19056881) RGD PMID:19056881 NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585 		JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3526851 (PMID:19056881)		 Ensembl
RGD		 PMID:19056881 GO_REF:0000107 NCBI chr20:29,047,793...29,094,209
Ensembl chr20:29,047,796...29,094,084 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 involved_in IMP
ISO		 estradiol sulfation
(PMID:16221673)		 RGD PMID:16221673 PMID:14742143 RGD:2301073 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 acts_upstream_of_or_within
involved_in		 TAS
ISO
ISS		 MGI:3529586 (PMID:15685171)
(MGI:5447633|PMID:9765259)
GO_REF:0000024
(PMID:11884392)		 RGD
UniProt		 PMID:9765259 PMID:11884392 PMID:15685171 PMID:7857871 GO_REF:0000024 MGI:5447633, RGD:1299062 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase acts_upstream_of_or_within ISO MGI:3526866 (PMID:19056881) RGD PMID:19056881 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 involved_in ISO (PMID:15472229), (PMID:18719240), (PMID:19830808) RGD PMID:15472229 PMID:18719240 PMID:19830808 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 involved_in ISO (PMID:18719240) RGD PMID:18719240 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 involved_in ISO
IBA
IDA		 (PMID:18719240)
GO_REF:0000033		 RGD
GO_Central		 PMID:18719240 PMID:18719240 GO_REF:0000033, RGD:40902964 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 involved_in ISS
IBA		 GO_REF:0000024
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
G Ugt2b34l1 UDP glucuronosyltransferase 2 family, polypeptide B34 like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704 		JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 involved_in ISS
IBA		 GO_REF:0000024
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr14:20,853,441...20,891,039
Ensembl chr14:20,853,587...20,891,037 		JBrowse link
G Ugt2b37 UDP-glucuronosyltransferase 2 family, member 37 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:20,817,285...20,833,917
Ensembl chr14:20,817,285...20,833,917 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:18719240)		 UniProt
GO_Central
RGD		 PMID:18719240 GO_REF:0000024 GO_REF:0000033 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IDA estrone RGD PMID:19665544 RGD:4891164 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 involved_in IDA
IBA
ISO
IEA		 estradiol
GO_REF:0000033
(MGI:1267145|PMID:9658408)
GO_REF:0000041
(PMID:8994190)		 GO_Central
RGD
UniProt		 PMID:8994190 PMID:9658408 PMID:8612487 GO_REF:0000033 GO_REF:0000041 MGI:1267145, RGD:728619 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 involved_in IDA
IEA
ISO		 estrone
GO_REF:0000107
(PMID:11940569)		 Ensembl
RGD		 PMID:11940569 PMID:8612487 GO_REF:0000107, RGD:728619 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 involved_in IDA
ISO
IEA		 PMID:9658408
(MGI:1267145|PMID:9658408), (MGI:2662631|PMID:12732193)
(PMID:12732193)
GO_REF:0000107
GO_REF:0000041		 RGD
Ensembl
UniProt		 PMID:9658408 PMID:12732193 PMID:9658408 GO_REF:0000041 GO_REF:0000107 MGI:1267145 MGI:2662631, RGD:30309934 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017 		JBrowse link
G Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 involved_in IEA
IBA
ISO
ISS		 GO_REF:0000041
GO_REF:0000033
GO_REF:0000107
(PMID:17978863)
GO_REF:0000024		 UniProt
GO_Central
Ensembl
RGD		 PMID:17978863 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 NCBI chr20:4,826,725...4,828,742
Ensembl chr20:4,822,026...4,828,742 		JBrowse link
G Rdh8 retinol dehydrogenase 8 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:19,353,191...19,360,462
Ensembl chr 8:19,353,191...19,360,462 		JBrowse link
G Star steroidogenic acute regulatory protein IMP estradiol; positive regulation RGD PMID:16579833 RGD:1600078 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
estrogen catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sult1e1 sulfotransferase family 1E member 1 involved_in ISO
IEA		 (PMID:23207770)
GO_REF:0000107		 RGD
Ensembl		 PMID:23207770 GO_REF:0000107 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C IDA RGD PMID:15502008 RGD:2317077 NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
negative regulation of estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin involved_in ISO (PMID:24530842) RGD PMID:24530842 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    metabolic process 11456
      hormone metabolic process 251
        estrogen metabolic process 38
          estrogen biosynthetic process + 9
          estrogen catabolic process 2
Path 2
Term Annotations click to browse term
  biological_process 19692
    metabolic process 11456
      primary metabolic process 10015
        lipid metabolic process 1453
          steroid metabolic process 353
            estrogen metabolic process 38
              estrogen biosynthetic process + 9
              estrogen catabolic process 2
paths to the root