Ugt2b35 (UDP glucuronosyltransferase 2 family, polypeptide B35) - Rat Genome Database

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Gene: Ugt2b35 (UDP glucuronosyltransferase 2 family, polypeptide B35) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ugt2b35
Name: UDP glucuronosyltransferase 2 family, polypeptide B35
RGD ID: 620895
Description: Enables glucuronosyltransferase activity. Involved in aromatic compound catabolic process and response to xenobiotic stimulus. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to several human genes including UGT2B10 (UDP glucuronosyltransferase family 2 member B10); UGT2B11 (UDP glucuronosyltransferase family 2 member B11); and UGT2B15 (UDP glucuronosyltransferase family 2 member B15).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93327; UDP glucuronosyltransferase 2 family, polypeptide B15; UDP glucuronosyltransferase 2 family, polypeptide B36; UDP glycosyltransferase 2 family, polypeptide B4; UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 2B12; UDP-glucuronosyltransferase 2B15; UDP-glucuronosyltransferase 2B36; UDP-glucuronosyltransferase 2B4; UDPGT 2B12; UDPGT 2B15; UDPGT 2B36; UDPGT 2B4; Ugt2b12; Ugt2b15; Ugt2b36; Ugt2b4
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,208,389 - 21,245,893 (+)NCBIGRCr8
mRatBN7.21420,853,441 - 20,891,039 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,853,587 - 20,891,037 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1421,191,279 - 21,229,131 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01422,510,208 - 22,548,062 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01421,041,310 - 21,079,160 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01422,553,633 - 22,591,461 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1422,553,650 - 22,591,461 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01422,455,301 - 22,493,180 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41422,454,256 - 22,493,510 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11422,454,274 - 22,493,504 (+)NCBI
Celera1420,358,391 - 20,395,704 (+)NCBICelera
Cytogenetic Map14p21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols. Green MD, etal., Arch Biochem Biophys 1995 Oct 1;322(2):460-8.
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. N-glucuronidation of perfluorooctanesulfonamide by human, rat, dog, and monkey liver microsomes and by expressed rat and human UDP-glucuronosyltransferases. Xu L, etal., Drug Metab Dispos. 2006 Aug;34(8):1406-10. Epub 2006 May 23.
Additional References at PubMed
PMID:1906977   PMID:12477932   PMID:28442641  


Genomics

Variants

.
Variants in Ugt2b35
335 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 1 1 1
Medium 38 38 38 13 1 1
Low 2 18 2 14 2 7 7 6 1 12 7 7
Below cutoff 6 3 1 1 12 10 17 1

Sequence


RefSeq Acc Id: ENSRNOT00000002712   ⟹   ENSRNOP00000002712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1420,853,587 - 20,891,037 (+)Ensembl
Rnor_6.0 Ensembl1422,553,662 - 22,591,461 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092201   ⟹   ENSRNOP00000074037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1422,553,650 - 22,590,423 (+)Ensembl
RefSeq Acc Id: NM_001004271   ⟹   NP_001004271
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,208,441 - 21,245,893 (+)NCBI
mRatBN7.21420,853,587 - 20,891,039 (+)NCBI
Rnor_6.01422,553,662 - 22,591,461 (+)NCBI
Rnor_5.01422,455,301 - 22,493,180 (+)NCBI
RGSC_v3.41422,454,256 - 22,493,510 (+)RGD
Celera1420,358,391 - 20,395,704 (+)RGD
Sequence:
RefSeq Acc Id: XM_008770060   ⟹   XP_008768282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,208,389 - 21,226,726 (+)NCBI
mRatBN7.21420,853,441 - 20,861,373 (+)NCBI
Rnor_6.01422,553,633 - 22,561,154 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001004271 (Get FASTA)   NCBI Sequence Viewer  
  XP_008768282 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA83404 (Get FASTA)   NCBI Sequence Viewer  
  AAA83405 (Get FASTA)   NCBI Sequence Viewer  
  AAH78782 (Get FASTA)   NCBI Sequence Viewer  
  EDL89823 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002712
  ENSRNOP00000002712.3
GenBank Protein P36511 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001004271   ⟸   NM_001004271
- Peptide Label: precursor
- UniProtKB: P36511 (UniProtKB/Swiss-Prot),   Q68G19 (UniProtKB/TrEMBL),   F7FMW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768282   ⟸   XM_008770060
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000074037   ⟸   ENSRNOT00000092201
RefSeq Acc Id: ENSRNOP00000002712   ⟸   ENSRNOT00000002712

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36511-F1-model_v2 AlphaFold P36511 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699265
Promoter ID:EPDNEW_R9780
Type:multiple initiation site
Name:Ugt2b35_1
Description:UDP glucuronosyltransferase 2 family, polypeptide B35
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01422,553,651 - 22,553,711EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620895 AgrOrtholog
BioCyc Gene G2FUF-16100 BioCyc
BioCyc Pathway PWY-5874 [heme degradation I] BioCyc
  PWY-6261 [thyroid hormone metabolism II (via conjugation and/or degradation)] BioCyc
  PWY-6313 [serotonin degradation] BioCyc
  PWY-6398 [melatonin degradation I] BioCyc
BioCyc Pathway Image PWY-5874 BioCyc
  PWY-6261 BioCyc
  PWY-6313 BioCyc
  PWY-6398 BioCyc
Ensembl Genes ENSRNOG00000001980 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002712 ENTREZGENE
  ENSRNOT00000002712.6 UniProtKB/TrEMBL
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7107952 IMAGE-MGC_LOAD
InterPro UDP_glucos_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83808 UniProtKB/TrEMBL
MGC_CLONE MGC:93327 IMAGE-MGC_LOAD
NCBI Gene 83808 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP-GLUCURONOSYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB UGT2B15 RGD
PhenoGen Ugt2b35 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001980 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F7FMW8 ENTREZGENE, UniProtKB/TrEMBL
  P36511 ENTREZGENE
  Q68G19 ENTREZGENE, UniProtKB/TrEMBL
  UDB15_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-23 Ugt2b35  UDP glucuronosyltransferase 2 family, polypeptide B35  Ugt2b15  UDP glucuronosyltransferase 2 family, polypeptide B15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-02 Ugt2b15  UDP glucuronosyltransferase 2 family, polypeptide B15  Ugt2b36  UDP glucuronosyltransferase 2 family, polypeptide B36  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Ugt2b36  UDP glucuronosyltransferase 2 family, polypeptide B36  Ugt2b4  UDP glycosyltransferase 2 family, polypeptide B4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ugt2b4  UDP glycosyltransferase 2 family, polypeptide B4  Ugt2b12  UDP-glucuronosyltransferase  Symbol and Name updated 1299863 APPROVED
2002-08-07 Ugt2b12  UDP-glucuronosyltransferase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein subunit molecular mass of 53 kDa 729992