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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:trypanosomiasis
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Accession:DOID:10113 term browser browse the term
Definition:A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans. (DO)
Synonyms:exact_synonym: Trypanosomiases
 primary_id: MESH:D014352
 xref: ICD10CM:B57.2;   ICD9CM:086
For additional species annotation, visit the Alliance of Genome Resources.


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trypanosomiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IEP RGD PMID:17722867 RGD:10046041 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Ada adenosine deaminase IEP RGD PMID:20809996 RGD:5128861 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Bche butyrylcholinesterase IEP protein:decreased expression:plasma RGD PMID:20138875 RGD:5687328 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Cd1d1 CD1d1 molecule exacerbates ISO RGD PMID:15731095 RGD:127345115 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Hp haptoglobin ISO protein:increased expression:plasma RGD PMID:19567273 RGD:11041867 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Il4 interleukin 4 treatment IEP RGD PMID:24731531 RGD:10402804 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Prf1 perforin 1 ISO RGD PMID:19651871 RGD:6482814 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701 		JBrowse link
G Tlr9 toll-like receptor 9 ISO mRNA:increased expression:liver (mouse) RGD PMID:18565585 RGD:18337478 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
Chagas Cardiomyopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 treatment IDA RGD PMID:24055715 RGD:7364866 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il23a interleukin 23 subunit alpha ISO RGD PMID:28356392 RGD:39457935 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Mbl2 mannose binding lectin 2 severity ISO RGD PMID:26745156 RGD:11076757 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Pcna proliferating cell nuclear antigen IEP protein:increased expression:myocardium: RGD PMID:12435130 RGD:10448990 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma disease_progression ISO mRNA:increased expression:heart (mouse)
mRNA:increased expression:heart (human)		 RGD PMID:29666415 PMID:29666415 PMID:29666415 RGD:38599151, RGD:38599151, RGD:38599151 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 susceptibility ISO DNA:polymorphism:exon (human) RGD PMID:19811437 RGD:5147589 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
Chagas disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 IEP RGD PMID:16844401 RGD:2307145 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 IEP RGD PMID:16844401 RGD:2307145 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IMP RGD PMID:20452453 RGD:4889906 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 ISO RGD PMID:9148906 RGD:5509585 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G F2 coagulation factor II, thrombin ISO protein:increased expression:blood plasma (human) RGD PMID:20699256 PMID:21866301 RGD:5147778, RGD:40818435 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 ISO RGD PMID:21801456 RGD:6218957 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Ifng interferon gamma IDA RGD PMID:10684988 RGD:10755744 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il23a interleukin 23 subunit alpha susceptibility ISO RGD PMID:23182712 RGD:39457956 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Prg2 proteoglycan 2, pro eosinophil major basic protein ISO mRNA:increased expression:plancenta (human) RGD PMID:29545200 RGD:40902989 NCBI chr 3:70,062,535...70,066,102
Ensembl chr 3:70,062,535...70,066,101 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 susceptibility ISO DNA:polymorphisms:exon (human) RGD PMID:19811437 RGD:5147589 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G Soat1 sterol O-acyltransferase 1 ameliorates ISO DNA:SNP:exon: rs1044925 (human) RGD PMID:31236660 RGD:126925205 NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494 		JBrowse link
G Vim vimentin severity IEP
ISO		 protein:increased expression:plasma RGD PMID:22199233 PMID:22199233 RGD:6480538, RGD:6480538 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
sleeping sickness term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEP RGD PMID:25595977 RGD:405650615 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Hcrt hypocretin neuropeptide precursor IEP RGD PMID:25595977 RGD:405650615 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Nos2 nitric oxide synthase 2 IEP protein:altered activity:brain, peritoneal macrophage RGD PMID:20169057 RGD:4891375 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pmch pro-melanin-concentrating hormone IEP RGD PMID:25595977 RGD:405650615 NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250 		JBrowse link
G Tslp thymic stromal lymphopoietin susceptibility ISO protein:increased expression:serum (mouse) RGD PMID:28769924 RGD:38549587 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18970
    disease by infectious agent 2216
      parasitic infectious disease 327
        parasitic protozoa infectious disease 176
          trypanosomiasis 29
            Bovine Trypanosomiasis 0
            Chagas disease + 16
            Dourine 0
            sleeping sickness 5
Path 2
Term Annotations click to browse term
  disease 18970
    disease by infectious agent 2216
      parasitic infectious disease 327
        parasitic protozoa infectious disease 176
          Euglenozoa Infections 86
            trypanosomiasis 29
              Bovine Trypanosomiasis 0
              Chagas disease + 16
              Dourine 0
              sleeping sickness 5
paths to the root