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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Chagas Cardiomyopathy
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Accession:DOID:9004422 term browser browse the term
Definition:A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
Synonyms:exact_synonym: Cardiovascular Trypanosomiasis;   Myocarditis, Chagas
 primary_id: MESH:D002598;   RDO:0005179
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants           Sort by:
Chagas Cardiomyopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 treatment IDA RGD PMID:24055715 RGD:7364866 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il23a interleukin 23 subunit alpha ISO RGD PMID:28356392 RGD:39457935 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Mbl2 mannose binding lectin 2 severity ISO RGD PMID:26745156 RGD:11076757 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Pcna proliferating cell nuclear antigen IEP protein:increased expression:myocardium: RGD PMID:12435130 RGD:10448990 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma disease_progression ISO mRNA:increased expression:heart (mouse)
mRNA:increased expression:heart (human)
RGD PMID:29666415, PMID:29666415, PMID:29666415 RGD:38599151, RGD:38599151, RGD:38599151 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 susceptibility ISO DNA:polymorphism:exon (human) RGD PMID:19811437 RGD:5147589 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    disease of anatomical entity 15278
      cardiovascular system disease 4424
        heart disease 2667
          cardiomyopathy 1089
            Chagas Cardiomyopathy 6
Path 2
Term Annotations click to browse term
  disease 16023
    disease by infectious agent 1774
      parasitic infectious disease 240
        parasitic protozoa infectious disease 143
          Euglenozoa Infections 68
            trypanosomiasis 23
              Chagas disease 14
                Chagas Cardiomyopathy 6
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.