RGD Reference Report - Protective actions of melatonin against heart damage during chronic Chagas disease. - Rat Genome Database
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Protective actions of melatonin against heart damage during chronic Chagas disease.

Authors: Oliveira, LG  Kuehn, CC  Santos, CD  Miranda, MA  Da Costa, CM  Mendonca, VJ  Do Prado JC, JUNIOR 
Citation: Oliveira LG, etal., Acta Trop. 2013 Sep 19. pii: S0001-706X(13)00249-0. doi: 10.1016/j.actatropica.2013.09.014.
RGD ID: 7364866
Pubmed: (View Article at PubMed) PMID:24055715
DOI: Full-text: DOI:10.1016/j.actatropica.2013.09.014

Chronic cardiomyopathy is the most important clinical form of Chagas disease, and it is characterised by myocarditis that is associated with fibrosis and organ dysfunction. Alternative treatment options are important tools to modulate host immune responses. The main goal of this work was to evaluate the anti-inflammatory actions of melatonin during the chronic phase of Chagas disease. TNF-alpha, IL-10 and nitrite concentrations were evaluated as predictive factors of immune modulation. Creatine phosphokinase-MB (CK-MB), cardiac inflammatory foci and heart weight were assessed to evaluate the efficacy of the melatonin treatment. Male Wistar rats were infected with 1x105 blood trypomastigotes of the Y strain of Trypanosoma cruzi and kept untreated for 60 days to mimic chronic infection. After this period, the rats were orally treated with melatonin 50mg/kg/day, and the experiments were performed 90, 120, and 180 days post-infection. Melatonin treatment significantly increased the concentration of IL-10 and reduced the concentrations of NO and TNF-alpha produced by cardiomyocytes. Furthermore, it led to decreased heart weight, serum CK-MB levels and inflammatory foci when compared to the untreated and infected control groups. We conclude that melatonin therapy is effective at protecting animals against the harmful cardiac inflammatory response that is characteristic of chronic T. cruzi infection.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


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