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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Chagas disease
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Accession:DOID:12140 term browser browse the term
Definition:Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
Synonyms:exact_synonym: American Trypanosomiasis;   South American Trypanosomiasis;   chagas' disease with digestive system involvement;   chagas' disease with nervous system involvement;   chagas' disease with other organ involvement
 primary_id: MESH:D014355;   RDO:0005180
 xref: GARD:6030;   ICD9CM:086.2
For additional species annotation, visit the Alliance of Genome Resources.


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Chagas disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 IEP RGD PMID:16844401 RGD:2307145 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 IEP RGD PMID:16844401 RGD:2307145 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IMP RGD PMID:20452453 RGD:4889906 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 ISO RGD PMID:9148906 RGD:5509585 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G F2 coagulation factor II ISO protein:increased expression:blood plasma (human) RGD PMID:20699256, PMID:21866301 RGD:5147778, RGD:40818435 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 ISO RGD PMID:21801456 RGD:6218957 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Ifng interferon gamma IDA RGD PMID:10684988 RGD:10755744 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il23a interleukin 23 subunit alpha susceptibility ISO RGD PMID:23182712 RGD:39457956 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 susceptibility ISO DNA:polymorphisms:exon (human) RGD PMID:19811437 RGD:5147589 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G Vim vimentin severity IEP
ISO
protein:increased expression:plasma RGD PMID:22199233, PMID:22199233 RGD:6480538, RGD:6480538 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
Chagas Cardiomyopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 treatment IDA RGD PMID:24055715 RGD:7364866 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il23a interleukin 23 subunit alpha ISO RGD PMID:28356392 RGD:39457935 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Mbl2 mannose binding lectin 2 severity ISO RGD PMID:26745156 RGD:11076757 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Pcna proliferating cell nuclear antigen IEP protein:increased expression:myocardium: RGD PMID:12435130 RGD:10448990 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma disease_progression ISO mRNA:increased expression:heart (mouse)
mRNA:increased expression:heart (human)
RGD PMID:29666415, PMID:29666415, PMID:29666415 RGD:38599151, RGD:38599151, RGD:38599151 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 susceptibility ISO DNA:polymorphism:exon (human) RGD PMID:19811437 RGD:5147589 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16035
    disease by infectious agent 1775
      parasitic infectious disease 240
        parasitic protozoa infectious disease 143
          trypanosomiasis 23
            Chagas disease 14
              Chagas Cardiomyopathy 6
Path 2
Term Annotations click to browse term
  disease 16035
    disease by infectious agent 1775
      parasitic infectious disease 240
        parasitic protozoa infectious disease 143
          Euglenozoa Infections 68
            trypanosomiasis 23
              Chagas disease 14
                Chagas Cardiomyopathy 6
paths to the root