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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Phenelzine
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Accession:CHEBI:8060 term browser browse the term
Definition:A primary amine that has formula C8H12N2.
Synonyms:related_synonym: 1-hydrazino-2-phenylethane;   2-phenylethylhydrazine;   Formula=C8H12N2;   InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2;   InChIKey=RMUCZJUITONUFY-UHFFFAOYSA-N;   SMILES=NNCCc1ccccc1;   phenalzine;   phenelzine sulfate;   phenethylhydrazine
 xref: CAS:51-71-8;   Drug_Central:2123;   HMDB:HMDB0014918;   KEGG:C07430;   KEGG:D08349;   LINCS:LSM-5928
 xref_mesh: MESH:D010624


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Phenelzine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam8 ADAM metallopeptidase domain 8 increases expression ISO Phenelzine results in increased expression of ADAM8 mRNA CTD PMID:31249575 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801 		JBrowse link
G Adamts2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 increases expression ISO Phenelzine results in increased expression of ADAMTS2 mRNA CTD PMID:31249575 NCBI chr10:34,920,992...35,126,465
Ensembl chr10:34,921,049...35,123,821 		JBrowse link
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 increases expression ISO Phenelzine results in increased expression of ADAMTS9 mRNA CTD PMID:31249575 NCBI chr 4:125,290,633...125,462,988
Ensembl chr 4:125,291,490...125,462,929 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression ISO Phenelzine results in increased expression of ALOX5AP mRNA CTD PMID:31249575 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 multiple interactions ISO Phenelzine inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140 		JBrowse link
G Apoe apolipoprotein E increases expression ISO Phenelzine results in increased expression of APOE mRNA CTD PMID:31249575 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Bche butyrylcholinesterase decreases expression ISO Phenelzine results in decreased expression of BCHE protein CTD PMID:5801348 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 affects expression ISO Phenelzine affects the expression of CCR7 mRNA CTD PMID:31249575 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G Cd36 CD36 molecule increases expression ISO Phenelzine results in increased expression of CD36 mRNA CTD PMID:31249575 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cga glycoprotein hormones, alpha polypeptide increases expression
multiple interactions		 EXP Phenelzine results in increased expression of CGA mRNA
Phenelzine inhibits the reaction [Triiodothyronine results in decreased expression of CGA mRNA]; Triiodothyronine inhibits the reaction [Phenelzine results in increased expression of CGA mRNA]		 CTD PMID:20148560 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191 		JBrowse link
G Col12a1 collagen type XII alpha 1 chain increases expression ISO Phenelzine results in increased expression of COL12A1 mRNA CTD PMID:31249575 NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686 		JBrowse link
G Col15a1 collagen type XV alpha 1 chain increases expression ISO Phenelzine results in increased expression of COL15A1 mRNA CTD PMID:31249575 NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591 		JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO Phenelzine results in increased expression of COL1A2 mRNA CTD PMID:31249575 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Crh corticotropin releasing hormone decreases expression EXP Phenelzine results in decreased expression of CRH mRNA CTD PMID:1351783 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Phenelzine results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Phenelzine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity		 ISO Phenelzine inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
Phenelzine results in decreased activity of CYP2B6 protein		 CTD PMID:25656918 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity
multiple interactions		 ISO Phenelzine results in decreased activity of CYP2C8 protein
torsemide inhibits the reaction [Phenelzine results in decreased activity of CYP2C8 protein]		 CTD PMID:15304522
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Phenelzine results in decreased activity of CYP3A4 protein CTD PMID:15304522 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 increases expression ISO Phenelzine results in increased expression of EIF4EBP2 mRNA CTD PMID:31249575 NCBI chr20:29,379,444...29,400,110
Ensembl chr20:29,382,668...29,399,946 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 decreases expression ISO Phenelzine results in decreased expression of ENPP2 mRNA CTD PMID:31249575 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Phenelzine results in increased expression of FABP4 mRNA CTD PMID:31249575 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fpr2 formyl peptide receptor 2 affects expression ISO Phenelzine affects the expression of FPR2 mRNA CTD PMID:31249575 NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019 		JBrowse link
G Fut4 fucosyltransferase 4 increases expression ISO Phenelzine results in increased expression of FUT4 mRNA CTD PMID:31249575 NCBI chr 8:11,586,721...11,590,682
Ensembl chr 8:11,586,721...11,590,682 		JBrowse link
G Gpr18 G protein-coupled receptor 18 affects expression ISO Phenelzine affects the expression of GPR18 mRNA CTD PMID:31249575 NCBI chr15:98,997,427...99,001,177
Ensembl chr15:98,997,259...99,001,470 		JBrowse link
G Il12b interleukin 12B affects expression ISO Phenelzine affects the expression of IL12B mRNA CTD PMID:31249575 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta affects expression ISO Phenelzine affects the expression of IL1B mRNA CTD PMID:31249575 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 affects expression ISO Phenelzine affects the expression of IL6 mRNA CTD PMID:31249575 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO Phenelzine results in decreased expression of LDLR mRNA CTD PMID:31249575 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Maob monoamine oxidase B multiple interactions ISO Phenelzine inhibits the reaction [MAOB protein results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole] CTD PMID:26686552 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Nos2 nitric oxide synthase 2 affects expression ISO Phenelzine affects the expression of NOS2 mRNA CTD PMID:31249575 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO Phenelzine inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Plcb1 phospholipase C beta 1 decreases expression EXP Phenelzine results in decreased expression of PLCB1 mRNA; Phenelzine results in decreased expression of PLCB1 protein CTD PMID:12527476 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Serinc2 serine incorporator 2 decreases expression ISO Phenelzine results in decreased expression of SERINC2 mRNA CTD PMID:31249575 NCBI chr 5:142,592,308...142,614,628
Ensembl chr 5:142,592,309...142,618,364 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO Phenelzine results in decreased expression of SERPINE1 mRNA CTD PMID:31249575 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 increases expression ISO Phenelzine results in increased expression of SGPP1 mRNA CTD PMID:31249575 NCBI chr 6:94,425,339...94,446,534
Ensembl chr 6:94,425,339...94,446,534 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Phenelzine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Th tyrosine hydroxylase increases expression EXP Phenelzine results in increased expression of TH mRNA CTD PMID:1351783 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression ISO Phenelzine results in increased expression of TIMP3 mRNA CTD PMID:31249575 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Phenelzine results in increased expression of VCAM1 mRNA CTD PMID:31249575 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19814
      application 19658
        NMR chemical shift reference compound 17961
          ammonia 17820
            organic amino compound 17820
              amine 8281
                primary amine 6328
                  Phenelzine 40
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    main group molecular entity 19786
                      s-block molecular entity 19624
                        hydrogen molecular entity 19611
                          hydrides 19117
                            inorganic hydride 18115
                              pnictogen hydride 18104
                                nitrogen hydride 18011
                                  azane 17821
                                    ammonia 17820
                                      organic amino compound 17820
                                        primary amino compound 9312
                                          primary amine 6328
                                            Phenelzine 40
paths to the root