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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Brevianamide A
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Accession:CHEBI:200715 term browser browse the term
Synonyms:exact_synonym: 10',10'-dimethylspiro[1H-indole-2,11'-3,13-diazatetracyclo[5.5.2.01,9.03,7]tetradecane]-2',3,14'-trione
 related_synonym: Formula=C21H23N3O3;   InChI=1S/C21H23N3O3/c1-18(2)14-10-19-8-5-9-24(19)17(27)20(14,23-16(19)26)11-21(18)15(25)12-6-3-4-7-13(12)22-21/h3-4,6-7,14,22H,5,8-11H2,1-2H3,(H,23,26);   InChIKey=MWOFPQAPILIIPR-UHFFFAOYSA-N;   SMILES=O=C1N2C3(C(=O)NC14C(C(C)(C)C5(C4)NC=6C=CC=CC6C5=O)C3)CCC2
 xref: Chemspider:90141;   HMDB:HMDB0030380
 xref_mesh: MESH:C006794


show annotations for term's descendants           Sort by:
Brevianamide A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcf1 ATP binding cassette subfamily F member 1 increases expression ISO brevianamide A results in increased expression of ABCF1 mRNA CTD PMID:19818335 NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433 		JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 increases expression ISO brevianamide A results in increased expression of AIMP1 mRNA CTD PMID:19818335 NCBI chr 2:223,825,930...223,849,477
Ensembl chr 2:221,151,904...221,175,728 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO brevianamide A results in increased expression of CCL11 mRNA CTD PMID:19818335 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl12 C-C motif chemokine ligand 12 decreases expression
increases expression		 ISO brevianamide A results in decreased expression of CCL12 mRNA
brevianamide A results in increased expression of CCL12 mRNA		 CTD PMID:19818335 NCBI chr10:67,567,876...67,569,426
Ensembl chr10:67,070,230...67,071,780 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 increases expression ISO brevianamide A results in increased expression of CCL19 mRNA CTD PMID:19818335 NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO brevianamide A results in decreased expression of CCL2 mRNA CTD PMID:19818335 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression
increases expression		 ISO brevianamide A results in decreased expression of CCL20 mRNA
brevianamide A results in increased expression of CCL20 mRNA		 CTD PMID:19818335 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl24 C-C motif chemokine ligand 24 increases expression ISO brevianamide A results in increased expression of CCL24 mRNA CTD PMID:19818335 NCBI chr12:26,737,423...26,741,420
Ensembl chr12:21,100,835...21,104,893 		JBrowse link
G Ccl25 C-C motif chemokine ligand 25 increases expression ISO brevianamide A results in increased expression of CCL25 mRNA CTD PMID:19818335 NCBI chr12:7,505,231...7,514,402
Ensembl chr12:2,707,398...2,716,554 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO brevianamide A results in decreased expression of CCL4 mRNA CTD PMID:19818335 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO brevianamide A results in increased expression of CCL5 mRNA CTD PMID:19818335 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression ISO brevianamide A results in decreased expression of CCL7 mRNA CTD PMID:19818335 NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Ccr10 C-C motif chemokine receptor 10 increases expression ISO brevianamide A results in increased expression of CCR10 mRNA CTD PMID:19818335 NCBI chr10:86,608,836...86,611,273
Ensembl chr10:86,108,551...86,110,988 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO brevianamide A results in increased expression of CCR2 mRNA CTD PMID:19818335 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 increases expression ISO brevianamide A results in increased expression of CCR3 mRNA CTD PMID:19818335 NCBI chr 8:132,463,533...132,511,601
Ensembl chr 8:123,616,236...123,634,990 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 increases expression ISO brevianamide A results in increased expression of CCR4 mRNA CTD PMID:19818335 NCBI chr 8:123,054,505...123,060,244
Ensembl chr 8:114,176,974...114,178,056 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 increases expression ISO brevianamide A results in increased expression of CCR6 mRNA CTD PMID:19818335 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 increases expression ISO brevianamide A results in increased expression of CCR7 mRNA CTD PMID:19818335 NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G Ccr9 C-C motif chemokine receptor 9 increases expression ISO brevianamide A results in increased expression of CCR9 mRNA CTD PMID:19818335 NCBI chr 8:132,273,581...132,287,651
Ensembl chr 8:123,395,813...123,413,969 		JBrowse link
G Cd40lg CD40 ligand increases expression ISO brevianamide A results in increased expression of CD40LG mRNA CTD PMID:19818335 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression ISO brevianamide A results in increased expression of CX3CL1 mRNA CTD PMID:19818335 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO brevianamide A results in increased expression of CXCL12 mRNA CTD PMID:19818335 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 increases expression ISO brevianamide A results in increased expression of CXCL13 mRNA CTD PMID:19818335 NCBI chr14:13,912,858...13,917,920
Ensembl chr14:13,608,902...13,613,933 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO brevianamide A results in increased expression of CXCL2 protein CTD PMID:19818335 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO brevianamide A results in decreased expression of CXCL1 mRNA CTD PMID:19818335 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression ISO brevianamide A results in increased expression of CXCR2 mRNA CTD PMID:19818335 NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO brevianamide A results in increased expression of CXCR3 mRNA CTD PMID:19818335 NCBI chr  X:70,884,293...70,886,944
Ensembl chr  X:66,844,318...66,846,969 		JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 increases expression ISO brevianamide A results in increased expression of CXCR5 mRNA CTD PMID:19818335 NCBI chr 8:53,738,878...53,756,813
Ensembl chr 8:44,843,413...44,857,893 		JBrowse link
G Il10ra interleukin 10 receptor subunit alpha increases expression ISO brevianamide A results in increased expression of IL10RA mRNA CTD PMID:19818335 NCBI chr 8:54,459,754...54,474,786
Ensembl chr 8:45,563,137...45,578,061 		JBrowse link
G Il10rb interleukin 10 receptor subunit beta increases expression ISO brevianamide A results in increased expression of IL10RB mRNA CTD PMID:19818335 NCBI chr11:44,132,471...44,154,062
Ensembl chr11:30,652,096...30,668,074 		JBrowse link
G Il11 interleukin 11 increases expression ISO brevianamide A results in increased expression of IL11 mRNA CTD PMID:19818335 NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:69,068,137...69,076,129 		JBrowse link
G Il13 interleukin 13 increases expression ISO brevianamide A results in increased expression of IL13 mRNA CTD PMID:19818335 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 increases expression ISO brevianamide A results in increased expression of IL13RA1 mRNA CTD PMID:19818335 NCBI chr  X:120,213,670...120,294,777
Ensembl chr  X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681 		JBrowse link
G Il16 interleukin 16 increases expression ISO brevianamide A results in increased expression of IL16 mRNA CTD PMID:19818335 NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il18 interleukin 18 increases expression ISO brevianamide A results in increased expression of IL18 mRNA CTD PMID:19818335 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 increases expression ISO brevianamide A results in increased expression of IL1R1 mRNA CTD PMID:19818335 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il2rb interleukin 2 receptor subunit beta increases expression ISO brevianamide A results in increased expression of IL2RB mRNA CTD PMID:19818335 NCBI chr 7:111,913,828...111,928,537
Ensembl chr 7:110,033,341...110,048,054 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma increases expression ISO brevianamide A results in increased expression of IL2RG mRNA CTD PMID:19818335 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il6r interleukin 6 receptor increases expression ISO brevianamide A results in increased expression of IL6RA mRNA CTD PMID:19818335 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer increases expression ISO brevianamide A results in increased expression of IL6ST mRNA CTD PMID:19818335 NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:44,066,130...44,109,936 		JBrowse link
G Ltb lymphotoxin beta increases expression ISO brevianamide A results in increased expression of LTB mRNA CTD PMID:19818335 NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,627,537...3,629,381 		JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO brevianamide A results in increased expression of MIF mRNA CTD PMID:19818335 NCBI chr20:12,767,138...12,791,222
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504 		JBrowse link
G Pf4 platelet factor 4 increases expression ISO brevianamide A results in increased expression of PF4 mRNA CTD PMID:19818335 NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO brevianamide A results in increased expression of TGFB1 mRNA CTD PMID:19818335 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression		 ISO brevianamide A results in decreased expression of TNF mRNA
brevianamide A results in increased expression of TNF mRNA; brevianamide A results in increased expression of TNF protein		 CTD PMID:19818335 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO brevianamide A results in increased expression of TNFRSF1A mRNA CTD PMID:19818335 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO brevianamide A results in increased expression of TNFRSF1B mRNA CTD PMID:19818335 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19879
    chemical entity 19877
      group 19829
        polyatomic entity 19828
          molecule 19721
            cyclic compound 19516
              polycyclic compound 18828
                spiro compound 5004
                  azaspiro compound 876
                    Brevianamide A 47
Path 2
Term Annotations click to browse term
  CHEBI ontology 19879
    subatomic particle 19877
      composite particle 19877
        hadron 19877
          baryon 19877
            nucleon 19877
              atomic nucleus 19877
                atom 19877
                  main group element atom 19816
                    p-block element atom 19816
                      carbon group element atom 19756
                        carbon atom 19753
                          organic molecular entity 19753
                            organic molecule 19706
                              organic cyclic compound 19498
                                organic heterocyclic compound 18878
                                  organonitrogen heterocyclic compound 18155
                                    azaspiro compound 876
                                      Brevianamide A 47
paths to the root