Gsk3b (glycogen synthase kinase 3 beta) - Rat Genome Database

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Gene: Gsk3b (glycogen synthase kinase 3 beta) Rattus norvegicus
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Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
RGD ID: 70982
Description: Enables several functions, including ATP binding activity; protein serine/threonine kinase binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of neuron projection development; and regulation of synapse organization. Located in several cellular components, including axon; dendritic spine; and microtubule. Part of beta-catenin destruction complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study several diseases, including middle cerebral artery infarction; myocardial infarction; neurodegenerative disease (multiple); sciatic neuropathy; and vascular dementia. Biomarker of several diseases, including artery disease (multiple); depressive disorder; diabetic encephalopathy; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta); PARTICIPATES IN long term depression; Wnt signaling, canonical pathway; Bone morphogenetic proteins signaling pathway; INTERACTS WITH (R)-lipoic acid; (R)-salsolinol; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FA; factor A; glycogen synthase kinase-3 beta; GSK-3 beta; serine/threonine-protein kinase GSK3B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,004,502 - 76,154,665 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1176,009,507 - 76,153,249 (-)EnsemblGRCr8
mRatBN7.21162,498,997 - 62,648,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,504,316 - 62,648,646 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1171,316,816 - 71,460,263 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,979,039 - 64,122,494 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,029,506 - 63,172,937 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,060,884 - 65,208,842 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,066,235 - 65,209,268 (-)Ensemblrn6Rnor6.0
Rnor_5.01166,873,291 - 67,016,640 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41164,284,731 - 64,428,698 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1162,004,680 - 62,147,081 (-)NCBICelera
RGSC_v3.11164,342,319 - 64,486,287 (-)NCBI
RH 3.4 Map11501.41RGD
Cytogenetic Map11q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (IDA)
acute kidney failure  (ISO)
acute myocardial infarction  (IEP)
Alzheimer's disease  (IDA,ISO)
amyotrophic lateral sclerosis  (ISO)
bipolar disorder  (ISO)
Brain Injuries  (IEP,ISO)
Breast Neoplasms  (ISO)
Burns  (IEP)
Cardiomegaly  (IEP,ISO)
cognitive disorder  (ISO)
colon cancer  (IEP)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
congestive heart failure  (ISO)
degenerative disc disease  (ISO)
depressive disorder  (IEP,ISO)
diabetic encephalopathy  (IEP)
Diabetic Nephropathies  (IMP)
dilated cardiomyopathy  (ISO)
Drug-Induced Dyskinesia  (IMP)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Mammary Neoplasms  (IDA)
Hearing Loss, Cisplatin-Induced  (ISO)
heart disease  (IMP)
hypertension  (IEP,ISO)
intellectual disability  (ISO)
Intestinal Neoplasms  (ISO)
Liver Reperfusion Injury  (IDA)
mantle cell lymphoma  (ISO)
middle cerebral artery infarction  (IDA)
Multiple Abnormalities  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (IMP,ISO)
Myocardial Reperfusion Injury  (IDA,IEP)
Neoplastic Cell Transformation  (ISO)
neuronal ceroid lipofuscinosis 6A  (ISO)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
Parkinson's disease  (IDA)
peritonitis  (ISO)
Poisoning  (ISO)
Prostatic Neoplasms  (ISO)
schizophrenia  (IEP,ISO)
sciatic neuropathy  (IDA)
Sepsis  (IEP)
status epilepticus  (IEP)
Subarachnoid Hemorrhage  (IDA)
substance-related disorder  (IMP)
Tachycardia  (IDA)
tauopathy  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
urinary bladder cancer  (ISO)
vascular dementia  (IDA)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-salsolinol  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,8-cineole  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (EXP,ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-methylcholine  (ISO)
2-nitrotoluene  (EXP)
20-hydroxyecdysone  (EXP)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
3-methyladenine  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
5-methoxypsoralen  (ISO)
5alpha-pregnane-3,20-dione  (EXP)
6-aminonicotinamide  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (EXP)
adenosine  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alkaloid  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
alsterpaullone  (ISO)
aluminium hydroxide  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
andrographolide  (ISO)
antirheumatic drug  (ISO)
Antrocin  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
Atipamezole  (EXP)
atrazine  (ISO)
avobenzone  (ISO)
Azoxymethane  (ISO)
baicalein  (ISO)
BAPTA  (EXP)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
bellidifolin  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
brazilein  (ISO)
bromochloroacetic acid  (EXP)
Bufotalin  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calycosin  (EXP)
calyculin A  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
chaetoglobosin A  (EXP)
Chikusetsusaponin-V  (ISO)
CHIR 99021  (EXP,ISO)
chitosan  (EXP)
chloroethene  (ISO)
chlorogenic acid  (ISO)
chlorophyllin  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin 5,7-dimethyl ether  (EXP)
cilostazol  (ISO)
Cinobufagin  (ISO)
cisplatin  (EXP,ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
columbamine  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (ISO)
corynoline  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
curcumin  (EXP,ISO)
cyanidin cation  (EXP)
cycloastragenol  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP,ISO)
desmopressin  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (EXP)
diallyl disulfide  (ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
Didymin  (ISO)
dihydrolipoic acid  (ISO)
dioxygen  (EXP,ISO)
disodium cromoglycate  (EXP)
disodium selenite  (ISO)
dizocilpine maleate  (EXP,ISO)
dobutamine  (ISO)
donepezil hydrochloride  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
entinostat  (ISO)
enzacamene  (ISO)
erastin  (ISO)
erlotinib hydrochloride  (ISO)
estragole  (EXP)
ethanol  (EXP,ISO)
ethosuximide  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
excitatory amino acid agonist  (EXP,ISO)
famotidine  (ISO)
finasteride  (ISO)
fipronil  (ISO)
fisetin  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (EXP,ISO)
Fusaric acid  (ISO)
galactose  (ISO)
Gastrodin  (EXP,ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
Gentiopicrin  (ISO)
geraniol  (EXP)
gingerol  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (EXP)
ginsenoside Rg2  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
Glutathione ethyl ester  (ISO)
glycidol  (EXP)
glycidyl methacrylate  (ISO)
GSK2193874  (ISO)
GSK690693  (ISO)
haloperidol  (EXP)
hesperetin  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
IC-87114  (ISO)
icariside II  (ISO)
Icaritin  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoorientin  (ISO)
isoprenaline  (EXP,ISO)
isorhapontigenin  (ISO)
ivermectin  (ISO)
kaempferol  (EXP)
kahweol  (ISO)
kainic acid  (ISO)
kenpaullone  (EXP,ISO)
ketamine  (EXP)
KT 5823  (ISO)
L-ascorbic acid  (EXP)
L-glutamic acid  (EXP)
L-methionine  (ISO)
L-serine  (EXP)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
liraglutide  (ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP,ISO)
lithocholic acid  (ISO)
Lobetyolin  (ISO)
loliolide  (ISO)
lonafarnib  (ISO)
losartan  (EXP)
lovastatin  (EXP,ISO)
lupeol  (EXP)
LY294002  (EXP,ISO)
lysophosphatidylethanolamine  (ISO)
magnesium atom  (ISO)
Magnolol  (EXP)
malathion  (EXP)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
melatonin  (EXP,ISO)
memantine  (EXP)
menadione  (ISO)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (EXP)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
Mizoribine  (EXP)
MK-2206  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (EXP)
monodansylcadaverine  (ISO)
morin  (EXP)
morphine  (ISO)
mycophenolic acid  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-phosphocreatine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naloxone  (ISO)
nectandrin B  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitrofurazone  (EXP)
nitroprusside  (EXP,ISO)
nordihydroguaiaretic acid  (EXP)
notoginsenoside R1  (EXP,ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleic acid  (ISO)
oleuropein  (ISO)
omethoate  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
palmatine  (ISO)
Panaxadiol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parecoxib  (ISO)
pentetrazol  (EXP)
perfluorododecanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phloretin  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phytoestrogen  (EXP)
pioglitazone  (ISO)
pirfenidone  (ISO)
Plantamajoside  (EXP,ISO)
PNU-282987  (ISO)
potassium atom  (EXP)
potassium chromate  (ISO)
proanthocyanidin  (ISO)
procyanidin B1  (ISO)
procyanidin B2  (ISO)
progesterone  (EXP,ISO)
propofol  (EXP)
propranolol  (EXP)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyrithione  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quinacrine  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raffinose  (EXP,ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
risperidone  (EXP)
Ro 31-8220  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP)
royal jelly  (EXP)
rubimaillin  (ISO)
ruthenium atom  (ISO)
Salinomycin  (ISO)
Salvianolic acid A  (ISO)
SB 203580  (ISO)
SB 415286  (EXP,ISO)
SB 431542  (ISO)
SB-239063  (EXP)
sclareol  (ISO)
selenium atom  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sesquiterpene  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sinensetin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfasalazine  (EXP)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
syringic acid  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tadalafil  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
taurine  (ISO)
taurochenodeoxycholic acid  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetrahydropalmatine  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
thymoquinone  (EXP,ISO)
tideglusib  (ISO)
titanium dioxide  (ISO)
tolonium chloride  (ISO)
toluene 2,4-diisocyanate  (ISO)
topiramate  (EXP)
topotecan  (EXP)
Torularhodin  (EXP)
trametinib  (ISO)
trichloroethene  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
Ursonic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vanillic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vitamin K  (EXP)
warfarin  (EXP)
wogonin  (EXP,ISO)
wortmannin  (EXP,ISO)
xanthosine  (EXP)
XAV939  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
autosome genomic imprinting  (ISO)
axonogenesis  (ISO)
bone remodeling  (IDA)
canonical Wnt signaling pathway  (IEA,ISO)
cell differentiation  (IBA,IEA)
cell growth involved in cardiac muscle cell development  (IDA)
cell migration  (ISO)
cellular response to amyloid-beta  (IDA)
cellular response to dopamine  (IEP)
cellular response to erythropoietin  (IEP)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (IEP)
cellular response to interleukin-3  (ISO,ISS)
cellular response to iron(II) ion  (IEP)
cellular response to lithium ion  (IEP)
cellular response to mechanical stimulus  (IDA)
cellular response to retinoic acid  (IEA,ISO)
circadian rhythm  (ISO,ISS)
conditioned place preference  (IDA)
epithelial to mesenchymal transition  (IEA,ISO,ISS)
ER overload response  (ISO)
establishment of cell polarity  (IDA,IMP)
establishment or maintenance of cell polarity  (IDA)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO,ISS)
fat cell differentiation  (ISO)
glycogen metabolic process  (IEA,ISO)
hepatic stellate cell activation  (IMP)
hepatocyte apoptotic process  (IDA)
hippocampus development  (IEA,ISO)
insulin receptor signaling pathway  (IBA,ISO)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
maintenance of cell polarity  (IMP)
meiosis I  (ISO)
mitochondrion organization  (IEA,ISO)
myoblast fusion  (ISO)
myotube differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of calcineurin-NFAT signaling cascade  (IEA,ISO,ISS)
negative regulation of canonical Wnt signaling pathway  (IBA,IEA,ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of dendrite development  (IEA,IMP)
negative regulation of dendrite morphogenesis  (IMP)
negative regulation of developmental process  (IEA)
negative regulation of dopaminergic neuron differentiation  (IMP)
negative regulation of epithelial to mesenchymal transition  (IEA,ISO,ISS)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO,ISS)
negative regulation of gene expression  (ISO)
negative regulation of glycogen biosynthetic process  (ISO)
negative regulation of insulin receptor signaling pathway  (IDA,IEA)
negative regulation of MAP kinase activity  (IMP)
negative regulation of mesenchymal stem cell differentiation  (IEA,ISO)
negative regulation of neuron maturation  (ISO)
negative regulation of neuron migration  (IMP)
negative regulation of neuron projection development  (ISO)
negative regulation of nitric-oxide synthase activity  (IMP)
negative regulation of osteoblast differentiation  (IEA,ISO)
negative regulation of protein localization to centrosome  (ISO)
negative regulation of protein localization to nucleus  (IMP)
negative regulation of protein-containing complex assembly  (IEA,ISO)
negative regulation of signal transduction  (IEA)
negative regulation of smooth muscle cell apoptotic process  (IMP)
negative regulation of synaptic assembly at neuromuscular junction  (IMP)
negative regulation of TOR signaling  (IBA,ISO)
negative regulation of TORC2 signaling  (IEA,ISO,ISS)
nervous system development  (IEA)
neuron projection development  (IEA,ISO,ISS)
neuron projection organization  (IMP)
peptidyl-serine phosphorylation  (ISO,ISS)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
phosphorylation  (ISO)
positive regulation of apoptotic process  (IDA,IMP)
positive regulation of autophagy  (IBA,ISO,ISS)
positive regulation of axon extension  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cell differentiation  (IEA,ISO)
positive regulation of cell-matrix adhesion  (IEA,ISO)
positive regulation of cilium assembly  (ISO,ISS)
positive regulation of DNA biosynthetic process  (IMP)
positive regulation of excitatory postsynaptic potential  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of mitochondrial membrane potential  (IMP)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO,ISS)
positive regulation of neuron apoptotic process  (IBA,IEA,IMP)
positive regulation of osteoblast proliferation  (IMP)
positive regulation of osteoclast differentiation  (IMP)
positive regulation of osteoclast proliferation  (IMP)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,IEA,ISO)
positive regulation of protein catabolic process  (IMP)
positive regulation of protein export from nucleus  (ISO)
positive regulation of protein localization to centrosome  (IEA,ISO)
positive regulation of protein localization to cilium  (ISO,ISS)
positive regulation of protein ubiquitination  (IEA,ISO)
positive regulation of protein-containing complex assembly  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of stem cell differentiation  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
positive regulation of synaptic assembly at neuromuscular junction  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of type I interferon production  (ISO,ISS)
presynaptic modulation of chemical synaptic transmission  (IEA,ISO)
protein autophosphorylation  (ISO)
protein export from nucleus  (ISO)
protein localization to microtubule  (ISO)
protein phosphorylation  (IDA,ISO)
re-entry into mitotic cell cycle  (ISO)
regulation of apoptotic process  (ISO)
regulation of axon extension  (IMP)
regulation of axonogenesis  (IMP)
regulation of cell growth  (ISO)
regulation of circadian rhythm  (ISO,ISS)
regulation of dendrite morphogenesis  (IMP)
regulation of long-term synaptic potentiation  (ISO,ISS)
regulation of microtubule anchoring at centrosome  (IEA,ISO)
regulation of microtubule cytoskeleton organization  (IBA,IMP)
regulation of microtubule-based process  (IEA,ISO,ISS)
regulation of modification of postsynaptic structure  (IDA,IMP)
regulation of neuron projection development  (IBA,ISO)
regulation of neuronal synaptic plasticity  (IMP)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (IDA,IMP)
regulation of osteoblast differentiation  (IMP)
regulation of protein export from nucleus  (IEA,ISO)
response to activity  (IEP)
response to angiotensin  (IEP)
response to endoplasmic reticulum stress  (IEA,ISO)
response to epinephrine  (IEP)
response to estradiol  (IEP)
response to insulin  (IEP)
response to insulin-like growth factor stimulus  (IEP)
response to L-glutamate  (IEP)
response to methamphetamine hydrochloride  (IDA)
response to ultrasound  (IEP)
response to xenobiotic stimulus  (IEP)
response to zinc ion  (IDA)
rhythmic process  (IEA)
superior temporal gyrus development  (IEA,ISO)
Wnt signaling pathway  (IEA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
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69. Gene Data Set MGD Curation, June 12, 2002
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74. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
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82. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
83. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
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89. GOA pipeline RGD automated data pipeline
90. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
91. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
92. PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3beta signaling pathway in DMH induced early colon carcinogenesis in rat. Saini MK and Sanyal SN, Exp Mol Pathol. 2012 Aug;93(1):135-46. doi: 10.1016/j.yexmp.2012.04.019. Epub 2012 Apr 25.
93. Nuclear expression of glycogen synthase kinase-3ß and lack of membranous ß-catenin is correlated with poor survival in colon cancer. Salim T, etal., Int J Cancer. 2013 Aug 15;133(4):807-15. doi: 10.1002/ijc.28074. Epub 2013 Mar 9.
94. Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling. Sanchez JF, etal., Mol Cell Biol 2003 Jul;23(13):4649-62.
95. Protective effect of erythropoietin against ketamine-induced apoptosis in cultured rat cortical neurons: involvement of PI3K/Akt and GSK-3 beta pathway. Shang Y, etal., Apoptosis. 2007 Dec;12(12):2187-95.
96. Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival. Song B, etal., J Biol Chem. 2010 Dec 24;285(52):41122-34. doi: 10.1074/jbc.M110.130351. Epub 2010 Sep 14.
97. Recruitment of active glycogen synthase kinase-3 into neuronal lipid rafts. Sui Z, etal., Biochem Biophys Res Commun. 2006 Jul 14;345(4):1643-8. Epub 2006 May 24.
98. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling. Sunters A, etal., J Biol Chem. 2010 Mar 19;285(12):8743-58. doi: 10.1074/jbc.M109.027086. Epub 2009 Dec 30.
99. Association analysis of the GSK-3beta T-50C gene polymorphism with schizophrenia and bipolar disorder. Szczepankiewicz A, etal., Neuropsychobiology. 2006;53(1):51-6. Epub 2006 Jan 4.
100. Prenatal stress decreases glycogen synthase kinase-3 phosphorylation in the rat frontal cortex. Szymanska M, etal., Pharmacol Rep. 2009 Jul-Aug;61(4):612-20.
101. DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3ß and expressions of cyclin D1 and TCF7L2 in cancer model mice. Takahashi-Yanaga F, etal., Biochem Pharmacol. 2014 Jun 1;89(3):340-8. doi: 10.1016/j.bcp.2014.03.006. Epub 2014 Mar 23.
102. GSK-3alpha/beta-mediated phosphorylation of CRMP-2 regulates activity-dependent dendritic growth. Tan M, etal., J Neurochem. 2013 Jun;125(5):685-97. doi: 10.1111/jnc.12230. Epub 2013 Mar 25.
103. Mitotic clonal expansion: a synchronous process required for adipogenesis. Tang QQ, etal., Proc Natl Acad Sci U S A 2003 Jan 7;100(1):44-9. Epub 2002 Dec 26.
104. Increased GSK-3ß expression in DRG microglia in response to sciatic nerve crush. Tang W, etal., Acta Biochim Biophys Sin (Shanghai). 2016 Jun;48(6):581-3. doi: 10.1093/abbs/gmw027. Epub 2016 Apr 28.
105. Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains. Tian M, etal., FEBS Lett. 2012 Oct 19;586(20):3737-45. doi: 10.1016/j.febslet.2012.09.004. Epub 2012 Sep 13.
106. Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons. Tong N, etal., Eur J Neurosci. 2001 May;13(10):1913-22.
107. Iron-induced oxidative injury differentially regulates PI3K/Akt/GSK3beta pathway in synaptic endings from adult and aged rats. Uranga RM, etal., Toxicol Sci. 2009 Oct;111(2):331-44. doi: 10.1093/toxsci/kfp152. Epub 2009 Jul 16.
108. Glycogen synthase kinase 3 beta regulates ethanol consumption and is a risk factor for alcohol dependence. van der Vaart A, etal., Neuropsychopharmacology. 2018 Sep 6. pii: 10.1038/s41386-018-0202-x. doi: 10.1038/s41386-018-0202-x.
109. Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity. Vohra BP, etal., J Neurosci. 2007 Aug 29;27(35):9458-68.
110. Upregulation of glycogen synthase kinase 3ß in human colorectal adenocarcinomas correlates with accumulation of CTNNB1. Wang HL, etal., Clin Colorectal Cancer. 2011 Mar 1;10(1):30-6. doi: 10.3816/CCC.2011.n.004.
111. Calycosin ameliorates diabetes-induced cognitive impairments in rats by reducing oxidative stress via the PI3K/Akt/GSK-3ß signaling pathway. Wang X and Zhao L, Biochem Biophys Res Commun. 2016 Apr 29;473(2):428-34. doi: 10.1016/j.bbrc.2016.03.024. Epub 2016 Mar 10.
112. [Expression and significance of p-AKT, p-GSK3ß and ß-catenin in epithelial carcinoma of ovary]. Wei X, etal., Zhonghua Bing Li Xue Za Zhi. 2012 Feb;41(2):86-90.
113. Microtubule stabilization specifies initial neuronal polarization. Witte H, etal., J Cell Biol. 2008 Feb 11;180(3):619-32. doi: 10.1083/jcb.200707042.
114. Molecular cloning and expression of glycogen synthase kinase-3/factor A. Woodgett JR EMBO J 1990 Aug;9(8):2431-8.
115. Purinergic P2X7 receptor mediates acetaldehyde-induced hepatic stellate cells activation via PKC-dependent GSK3ß pathway. Wu X, etal., Int Immunopharmacol. 2017 Feb;43:164-171. doi: 10.1016/j.intimp.2016.12.017. Epub 2017 Jan 3.
116. Zinc stimulates glucose consumption by modulating the insulin signaling pathway in L6 myotubes: essential roles of Akt-GLUT4, GSK3ß and mTOR-S6K1. Wu Y, etal., J Nutr Biochem. 2016 Aug;34:126-35. doi: 10.1016/j.jnutbio.2016.05.008. Epub 2016 May 31.
117. Protective Effect of Antenatal Antioxidant on Nicotine-Induced Heart Ischemia-Sensitive Phenotype in Rat Offspring. Xiao D, etal., PLoS One. 2016 Feb 26;11(2):e0150557. doi: 10.1371/journal.pone.0150557. eCollection 2016.
118. Role of glycogen synthase kinase 3 in ischemia-induced blood-brain barrier disruption in aged female rats. Xiao H, etal., J Neurochem. 2017 Jul;142(2):194-203. doi: 10.1111/jnc.14051. Epub 2017 May 26.
119. Inhibition of Glycogen Synthase Kinase-3ß (GSK-3ß) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats. Xie CL, etal., Sci Rep. 2016 Mar 21;6:23527. doi: 10.1038/srep23527.
120. Caspase-dependent and caspase-independent induction of apoptosis in breast cancer by fucoidan via the PI3K/AKT/GSK3ß pathway in vivo and in vitro. Xue M, etal., Biomed Pharmacother. 2017 Oct;94:898-908. doi: 10.1016/j.biopha.2017.08.013. Epub 2017 Aug 12.
121. Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos. Yamamoto H, etal., Mol Cell Biol 1998 May;18(5):2867-75.
122. Cannabidiol attenuates methamphetamine-induced conditioned place preference via the Sigma1R/AKT/GSK-3β/CREB signaling pathway in rats. Yang G, etal., Toxicol Res (Camb). 2020 May 9;9(3):202-211. doi: 10.1093/toxres/tfaa021. eCollection 2020 Jun.
123. Bu-Shen-Huo-Xue-Fang (BSHXF) modulates nucleus pulposus cell proliferation and extracellular matrix (ECM) remodeling in intervertebral disc degeneration through miR-483 regulation of Wnt pathway. Yang S, etal., J Cell Biochem. 2018 Feb 2. doi: 10.1002/jcb.26760.
124. Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain. Yin J, etal., J Pineal Res. 2006 Sep;41(2):124-9.
125. Glycogen synthase kinase 3ß inhibition as a therapeutic approach in the treatment of endometrial cancer. Yin Y, etal., Int J Mol Sci. 2013 Aug 12;14(8):16617-37. doi: 10.3390/ijms140816617.
126. Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor-dependent inhibition of glycogen synthase kinase-3 beta and a receptor-independent anti-oxidative action. Yu Y, etal., J Neurochem. 2008 Feb;104(4):946-56. Epub 2007 Nov 14.
127. 14-3-3 binds to and mediates phosphorylation of microtubule-associated tau protein by Ser9-phosphorylated glycogen synthase kinase 3beta in the brain. Yuan Z, etal., J Biol Chem 2004 Jun 18;279(25):26105-14. Epub 2004 Apr 8.
128. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
129. Inhibitory effect of oxymatrine on hepatocyte apoptosis via TLR4/PI3K/Akt/GSK-3ß signaling pathway. Zhang X, etal., World J Gastroenterol. 2017 Jun 7;23(21):3839-3849. doi: 10.3748/wjg.v23.i21.3839.
130. Activation of Akt/GSK-3beta/beta-catenin signaling pathway is involved in survival of neurons after traumatic brain injury in rats. Zhao S, etal., Neurol Res. 2012 May;34(4):400-7. doi: 10.1179/1743132812Y.0000000025.
131. The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation. Zhou F, et al., J Biol Chem. 2008 May 23;283(21):14506-15. doi: 10.1074/jbc.M706136200. Epub 2008 Mar 26.
132. [Impact of glycogen synthase kinase-3ß (GSK-3ß) inhibitor on Wnt and NF-¿B signal pathways in a rat model of diabetic nephropathy]. Zhou Y, etal., Zhonghua Bing Li Xue Za Zhi. 2015 Nov;44(11):783-7.
Additional References at PubMed
PMID:8382613   PMID:8638126   PMID:9072970   PMID:9601641   PMID:10318824   PMID:11104755   PMID:11782539   PMID:11955436   PMID:12130654   PMID:12154096   PMID:12432063   PMID:12526086  
PMID:12750461   PMID:12805290   PMID:12874278   PMID:14660640   PMID:14690523   PMID:14698990   PMID:14730361   PMID:14744935   PMID:14749367   PMID:14976126   PMID:15001529   PMID:15075227  
PMID:15132987   PMID:15192701   PMID:15282335   PMID:15448698   PMID:15456937   PMID:15465828   PMID:15525785   PMID:15574412   PMID:15632182   PMID:15668231   PMID:15731007   PMID:15737742  
PMID:15799972   PMID:15819880   PMID:15950778   PMID:16133867   PMID:16142243   PMID:16155008   PMID:16181430   PMID:16188939   PMID:16300633   PMID:16306159   PMID:16315267   PMID:16343426  
PMID:16365045   PMID:16478771   PMID:16516918   PMID:16537926   PMID:16543145   PMID:16600022   PMID:16645641   PMID:16680013   PMID:16794215   PMID:16810687   PMID:16816118   PMID:16854843  
PMID:16890161   PMID:16912034   PMID:16981698   PMID:16982692   PMID:17026964   PMID:17046157   PMID:17109063   PMID:17114649   PMID:17119919   PMID:17139249   PMID:17157278   PMID:17182001  
PMID:17203200   PMID:17242403   PMID:17292911   PMID:17330951   PMID:17427960   PMID:17450314   PMID:17555552   PMID:17562708   PMID:17675573   PMID:17711861   PMID:17852410   PMID:17931653  
PMID:17986005   PMID:17989287   PMID:17993264   PMID:17996850   PMID:18031715   PMID:18041091   PMID:18089761   PMID:18156211   PMID:18183482   PMID:18195042   PMID:18291594   PMID:18323734  
PMID:18342477   PMID:18348280   PMID:18387957   PMID:18424437   PMID:18437149   PMID:18461448   PMID:18467435   PMID:18508033   PMID:18569012   PMID:18624766   PMID:18643871   PMID:18675800  
PMID:18689794   PMID:18716223   PMID:18723505   PMID:18787224   PMID:18802025   PMID:18805899   PMID:18824542   PMID:18846110   PMID:18983912   PMID:19038973   PMID:19071093   PMID:19141611  
PMID:19201691   PMID:19218353   PMID:19274437   PMID:19364825   PMID:19432589   PMID:19505811   PMID:19549690   PMID:19581563   PMID:19706605   PMID:19801631   PMID:19830702   PMID:19833727  
PMID:19875195   PMID:19920216   PMID:20015977   PMID:20093356   PMID:20111716   PMID:20123978   PMID:20143200   PMID:20219996   PMID:20362550   PMID:20371704   PMID:20427381   PMID:20467782  
PMID:20526333   PMID:20549454   PMID:20623542   PMID:20659131   PMID:20684275   PMID:20692265   PMID:20864106   PMID:20890042   PMID:20937854   PMID:20981553   PMID:21047779   PMID:21061060  
PMID:21072211   PMID:21118991   PMID:21194439   PMID:21232147   PMID:21246087   PMID:21289184   PMID:21295697   PMID:21316358   PMID:21399614   PMID:21443457   PMID:21500552   PMID:21505854  
PMID:21607291   PMID:21660051   PMID:21700708   PMID:21709260   PMID:21867737   PMID:21875668   PMID:21911068   PMID:21935433   PMID:22039465   PMID:22057101   PMID:22064483   PMID:22294054  
PMID:22427704   PMID:22460328   PMID:22472057   PMID:22490960   PMID:22496446   PMID:22504905   PMID:22505033   PMID:22539723   PMID:22554777   PMID:22577147   PMID:22660580   PMID:22676038  
PMID:22796213   PMID:22828498   PMID:22899650   PMID:22910909   PMID:22965877   PMID:22975711   PMID:23002080   PMID:23015435   PMID:23028846   PMID:23074275   PMID:23147208   PMID:23168994  
PMID:23184662   PMID:23192081   PMID:23246341   PMID:23408424   PMID:23426897   PMID:23439225   PMID:23469846   PMID:23475611   PMID:23685950   PMID:23719092   PMID:23751897   PMID:23853095  
PMID:23860320   PMID:23940672   PMID:23943518   PMID:23948897   PMID:24070631   PMID:24165455   PMID:24178833   PMID:24213808   PMID:24227739   PMID:24248537   PMID:24270208   PMID:24275526  
PMID:24288674   PMID:24319657   PMID:24391509   PMID:24425879   PMID:24623780   PMID:24631206   PMID:24675471   PMID:24691545   PMID:24722055   PMID:24763696   PMID:24884462   PMID:24950409  
PMID:24967390   PMID:24974728   PMID:25118933   PMID:25126703   PMID:25169083   PMID:25231981   PMID:25265211   PMID:25284613   PMID:25323773   PMID:25367884   PMID:25390651   PMID:25394244  
PMID:25448005   PMID:25451640   PMID:25454285   PMID:25484286   PMID:25646586   PMID:25655048   PMID:25661318   PMID:25801253   PMID:25813855   PMID:25840567   PMID:25883115   PMID:25897075  
PMID:25935310   PMID:25986948   PMID:26093674   PMID:26104971   PMID:26160071   PMID:26184774   PMID:26242887   PMID:26271595   PMID:26305322   PMID:26554621   PMID:26719331   PMID:26804375  
PMID:26838164   PMID:27019634   PMID:27097102   PMID:27255602   PMID:27431999   PMID:27545607   PMID:27580017   PMID:27624386   PMID:27717746   PMID:27771700   PMID:27783302   PMID:27866373  
PMID:27991911   PMID:28057765   PMID:28126496   PMID:28143715   PMID:28276718   PMID:28286769   PMID:28298517   PMID:28383811   PMID:28447730   PMID:28553165   PMID:28556462   PMID:28595035  
PMID:28622174   PMID:28656644   PMID:28718684   PMID:28957873   PMID:29215720   PMID:29327199   PMID:29506051   PMID:29688389   PMID:29768193   PMID:29987974   PMID:30053369   PMID:30129387  
PMID:30143583   PMID:30173372   PMID:30176218   PMID:30203709   PMID:30249754   PMID:30539783   PMID:30660367   PMID:30703695   PMID:30710530   PMID:30868494   PMID:31197456   PMID:31234955  
PMID:31467921   PMID:31561361   PMID:31916218   PMID:32108985   PMID:32186754   PMID:32196616   PMID:32377749   PMID:32463939   PMID:32819597   PMID:32991876   PMID:33075004   PMID:33359910  
PMID:33392916   PMID:33559827   PMID:34047419   PMID:34399774   PMID:34948382   PMID:34975828   PMID:34979196   PMID:35168370   PMID:35182545   PMID:35951283   PMID:36315357   PMID:36372121  
PMID:36555273   PMID:37071257   PMID:37567011   PMID:37667918   PMID:37714275   PMID:37863169   PMID:38227464   PMID:38372092   PMID:38950736  


Genomics

Comparative Map Data
Gsk3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,004,502 - 76,154,665 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1176,009,507 - 76,153,249 (-)EnsemblGRCr8
mRatBN7.21162,498,997 - 62,648,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,504,316 - 62,648,646 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1171,316,816 - 71,460,263 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,979,039 - 64,122,494 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,029,506 - 63,172,937 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,060,884 - 65,208,842 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,066,235 - 65,209,268 (-)Ensemblrn6Rnor6.0
Rnor_5.01166,873,291 - 67,016,640 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41164,284,731 - 64,428,698 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1162,004,680 - 62,147,081 (-)NCBICelera
RGSC_v3.11164,342,319 - 64,486,287 (-)NCBI
RH 3.4 Map11501.41RGD
Cytogenetic Map11q21NCBI
GSK3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383119,821,321 - 120,094,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3119,821,321 - 120,094,994 (-)Ensemblhg38GRCh38
GRCh373119,540,168 - 119,813,294 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363121,028,233 - 121,295,203 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343121,028,237 - 121,295,203NCBI
Celera3117,949,905 - 118,223,017 (-)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3116,916,542 - 117,189,344 (-)NCBIHuRef
CHM1_13119,504,331 - 119,776,722 (-)NCBICHM1_1
T2T-CHM13v2.03122,541,048 - 122,814,129 (-)NCBIT2T-CHM13v2.0
Gsk3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391637,909,363 - 38,066,446 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1637,909,363 - 38,066,446 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381638,089,001 - 38,246,084 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,089,001 - 38,246,084 (+)Ensemblmm10GRCm38
MGSCv371638,089,087 - 38,246,165 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361638,008,240 - 38,165,318 (+)NCBIMGSCv36mm8
Celera1638,497,488 - 38,655,086 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1626.54NCBI
Gsk3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,495,422 - 19,671,137 (-)Ensembl
ChiLan1.0NW_00495542719,489,972 - 19,671,137 (-)NCBIChiLan1.0ChiLan1.0
GSK3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22117,803,084 - 118,069,881 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13117,803,362 - 118,073,878 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03116,943,205 - 117,215,001 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13123,856,047 - 124,126,747 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,861,379 - 124,126,771 (-)EnsemblpanPan2panpan1.1
GSK3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,458,369 - 23,659,878 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,463,767 - 23,659,666 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3323,488,457 - 23,689,804 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03323,696,164 - 23,823,688 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3323,714,581 - 23,900,333 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13323,500,322 - 23,702,303 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03323,541,326 - 23,742,436 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03324,104,403 - 24,306,119 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gsk3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602130,628,163 - 130,791,946 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365366,730,062 - 6,894,303 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365366,730,070 - 6,893,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSK3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,136,158 - 140,369,569 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113140,136,109 - 140,370,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213149,599,661 - 149,702,154 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.213149,431,156 - 149,510,315 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSK3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12260,732,449 - 61,002,735 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2260,733,465 - 60,997,239 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041105,307,531 - 105,584,674 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gsk3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473128,178,628 - 28,366,420 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473128,178,647 - 28,368,784 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gsk3b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1423,051,613 - 23,200,719 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gsk3b
946 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:42
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000003867
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat

Markers in Region
RH129577  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,595,373 - 62,595,562 (+)MAPPERmRatBN7.2
Rnor_6.01165,157,244 - 65,157,432NCBIRnor6.0
Rnor_5.01166,926,325 - 66,926,513UniSTSRnor5.0
RGSC_v3.41164,376,234 - 64,376,422UniSTSRGSC3.4
Celera1162,095,610 - 62,095,798UniSTS
RH 3.4 Map11500.3UniSTS
Cytogenetic Map11q21UniSTS
BE114445  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,547,085 - 62,547,238 (+)MAPPERmRatBN7.2
Rnor_6.01165,108,966 - 65,109,118NCBIRnor6.0
Rnor_5.01166,973,636 - 66,973,788UniSTSRnor5.0
RGSC_v3.41164,327,687 - 64,327,839UniSTSRGSC3.4
Celera1162,047,384 - 62,047,536UniSTS
RH 3.4 Map11499.4UniSTS
Cytogenetic Map11q21UniSTS
RH94787  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11501.41UniSTS
Cytogenetic Map11q21UniSTS
BM387580  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,644,613 - 62,644,780 (+)MAPPERmRatBN7.2
Rnor_6.01165,205,664 - 65,205,830NCBIRnor6.0
Rnor_5.01166,877,003 - 66,877,169UniSTSRnor5.0
RGSC_v3.41164,425,525 - 64,425,691UniSTSRGSC3.4
Celera1162,143,908 - 62,144,074UniSTS
RH 3.4 Map11500.4UniSTS
Cytogenetic Map11q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003867   ⟹   ENSRNOP00000003867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,009,853 - 76,153,249 (-)Ensembl
mRatBN7.2 Ensembl1162,504,316 - 62,648,646 (-)Ensembl
Rnor_6.0 Ensembl1165,066,235 - 65,208,837 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077612   ⟹   ENSRNOP00000075708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,017,308 - 76,153,249 (-)Ensembl
mRatBN7.2 Ensembl1162,504,316 - 62,648,643 (-)Ensembl
Rnor_6.0 Ensembl1165,073,691 - 65,209,268 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099641   ⟹   ENSRNOP00000094301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,009,507 - 76,153,249 (-)Ensembl
mRatBN7.2 Ensembl1162,504,316 - 62,648,643 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137379   ⟹   ENSRNOP00000110454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,018,135 - 76,153,249 (-)Ensembl
RefSeq Acc Id: NM_032080   ⟹   NP_114469
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,009,817 - 76,153,249 (-)NCBI
mRatBN7.21162,504,312 - 62,647,785 (-)NCBI
Rnor_6.01165,066,199 - 65,208,837 (-)NCBI
Rnor_5.01166,873,291 - 67,016,640 (+)NCBI
RGSC_v3.41164,284,731 - 64,428,698 (-)RGD
Celera1162,004,680 - 62,147,081 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248373   ⟹   XP_006248435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,004,502 - 76,154,630 (-)NCBI
mRatBN7.21162,498,997 - 62,648,661 (-)NCBI
Rnor_6.01165,060,884 - 65,208,842 (-)NCBI
Rnor_5.01166,873,291 - 67,016,640 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248375   ⟹   XP_006248437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,018,137 - 76,154,650 (-)NCBI
mRatBN7.21162,512,646 - 62,648,663 (-)NCBI
Rnor_6.01165,074,519 - 65,208,842 (-)NCBI
Rnor_5.01166,873,291 - 67,016,640 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088668   ⟹   XP_038944596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,004,502 - 76,102,010 (-)NCBI
mRatBN7.21162,498,997 - 62,596,522 (-)NCBI
RefSeq Acc Id: XM_039088669   ⟹   XP_038944597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,004,502 - 76,102,024 (-)NCBI
mRatBN7.21162,498,997 - 62,596,538 (-)NCBI
RefSeq Acc Id: XM_063270791   ⟹   XP_063126861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,017,308 - 76,154,665 (-)NCBI
RefSeq Acc Id: XM_063270792   ⟹   XP_063126862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,018,137 - 76,154,614 (-)NCBI
RefSeq Acc Id: XM_063270793   ⟹   XP_063126863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,004,502 - 76,102,004 (-)NCBI
RefSeq Acc Id: NP_114469   ⟸   NM_032080
- UniProtKB: P18266 (UniProtKB/Swiss-Prot),   A6IR80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248435   ⟸   XM_006248373
- Peptide Label: isoform X1
- UniProtKB: P18266 (UniProtKB/Swiss-Prot),   A0A0G2JSH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248437   ⟸   XM_006248375
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GL38 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075708   ⟸   ENSRNOT00000077612
Ensembl Acc Id: ENSRNOP00000003867   ⟸   ENSRNOT00000003867
RefSeq Acc Id: XP_038944597   ⟸   XM_039088669
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038944596   ⟸   XM_039088668
- Peptide Label: isoform X4
- UniProtKB: P18266 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000094301   ⟸   ENSRNOT00000099641
RefSeq Acc Id: XP_063126863   ⟸   XM_063270793
- Peptide Label: isoform X6
- UniProtKB: P18266 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063126861   ⟸   XM_063270791
- Peptide Label: isoform X2
- UniProtKB: A0A0G2KB98 (UniProtKB/TrEMBL),   A0A8I6GL38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126862   ⟸   XM_063270792
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GL38 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110454   ⟸   ENSRNOT00000137379
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18266-F1-model_v2 AlphaFold P18266 1-420 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698170
Promoter ID:EPDNEW_R8695
Type:single initiation site
Name:Gsk3b_1
Description:glycogen synthase kinase 3 beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,208,801 - 65,208,861EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70982 AgrOrtholog
BioCyc Gene G2FUF-21266 BioCyc
Ensembl Genes ENSRNOG00000002833 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000003867 ENTREZGENE
  ENSRNOT00000077612 ENTREZGENE
  ENSRNOT00000137379 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro GSK-3 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  STKc_GSK3 UniProtKB/Swiss-Prot
KEGG Report rno:84027 UniProtKB/Swiss-Prot
NCBI Gene 84027 ENTREZGENE
PANTHER GLYCOGEN SYNTHASE KINASE-3 ALPHA UniProtKB/Swiss-Prot
  PTHR24057:SF8 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Gsk3b PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002833 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0G2JSH4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KB98 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GL38 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LVW2_RAT UniProtKB/TrEMBL
  A6IR79_RAT UniProtKB/TrEMBL
  A6IR80 ENTREZGENE, UniProtKB/TrEMBL
  A6IR81_RAT UniProtKB/TrEMBL
  GSK3B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Gsk3b  glycogen synthase kinase 3 beta      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function serine/threonine kinase 70606
gene_function phosphorylates several substrates, including b-catenin, glycogen synthase, transcriptional factors and the translation initiation factor Eif2b 70606
gene_process regulates apoptosis downstream of PI3-kinase/Akt signaling 70606
gene_process plays a role in coupling metabolism and protein synthesis to growth factor stimulation 70606