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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3baffects response to substanceISOGSK3B (Homo sapiens)6480464CTDGSK3B protein affects the susceptibility to Arsenic TrioxidePMID:21278055
Gsk3bdecreases phosphorylationISOGSK3B (Homo sapiens)6480464CTDArsenic Trioxide results in decreased phosphorylation of GSK3B proteinPMID:25416439 PMID:32305283
Gsk3bincreases expressionISOGSK3B (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of GSK3B mRNAPMID:22521957
Gsk3bincreases phosphorylationISOGSK3B (Homo sapiens)6480464CTDArsenic Trioxide results in increased phosphorylation of GSK3B proteinPMID:21278055 PMID:25246272 PMID:26966376 PMID:30362509
Gsk3bincreases phosphorylationISOGsk3b (Mus musculus)6480464CTDArsenic Trioxide results in increased phosphorylation of GSK3B proteinPMID:30362509
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]; [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of GSK3B protein] which results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of CCND1 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]; AKT1 protein inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GSK3B protein]; Arsenic Trioxide inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]; Arsenic Trioxide inhibits the reaction [Sorafenib results in increased phosphorylation of GSK3B protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of GSK3B protein; AS3MT mRNA promotes the reaction [Arsenic Trioxide inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]]; Deoxyglucose inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]; GSK3B protein modified form affects the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; IGF2BP2 protein promotes the reaction [Arsenic Trioxide inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]]; METTL14 protein promotes the reaction [Arsenic Trioxide inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Arsenic Trioxide inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]]; N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GSK3B protein]; Palmitic Acid inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]; Rosiglitazone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]; Sorafenib inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GSK3B protein]; Taurine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]; U 0126 inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]PMID:21278055 PMID:23949314 PMID:25246272 PMID:25416439 PMID:30362509 PMID:32305283 PMID:35226250
Gsk3bmultiple interactionsISOGsk3b (Mus musculus)6480464CTDArsenic Trioxide inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]; Taurine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]PMID:30362509 PMID:35226250
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