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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bincreases ubiquitinationEXP 6480464CTDDexamethasone results in increased ubiquitination of GSK3B proteinPMID:24451375
Gsk3bmultiple interactionsEXP 6480464CTDDexamethasone results in increased expression of and results in decreased phosphorylation of GSK3B proteinPMID:20501703
Gsk3bdecreases expressionISOGsk3b (Mus musculus)6480464CTDDexamethasone results in decreased expression of GSK3B mRNAPMID:20462044
Gsk3bmultiple interactionsISOGsk3b (Mus musculus)6480464CTD14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in decreased expression of GSK3B mRNA; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of GSK3B protein; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein]; Berberine inhibits the reaction [Dexamethasone results in decreased expression of GSK3B mRNA]PMID:20462044 PMID:27475717 PMID:30248417 PMID:30665118
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