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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bdecreases expressionEXP 6480464CTDChlorpyrifos results in decreased expression of GSK3B mRNAPMID:18668222
Gsk3bincreases expressionEXP 6480464CTDChlorpyrifos results in increased expression of GSK3B mRNAPMID:30497708
Gsk3bmultiple interactionsEXP 6480464CTDkaempferol inhibits the reaction [Chlorpyrifos results in increased expression of GSK3B mRNA]PMID:30497708
Gsk3baffects activityISOGSK3B (Homo sapiens)6480464CTDChlorpyrifos affects the activity of GSK3B proteinPMID:34424684
Gsk3bdecreases expressionISOGsk3b (Mus musculus)6480464CTDChlorpyrifos results in decreased expression of GSK3B mRNAPMID:37019170
Gsk3bincreases expressionISOGsk3b (Mus musculus)6480464CTDChlorpyrifos results in increased expression of GSK3B mRNAPMID:29665406
Gsk3bincreases phosphorylationISOGsk3b (Mus musculus)6480464CTDChlorpyrifos results in increased phosphorylation of GSK3B proteinPMID:29404631
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide affects the reaction [Chlorpyrifos affects the activity of GSK3B protein]; [Acetylcysteine co-treated with Chlorpyrifos] results in increased activity of GSK3B protein; GSK3B protein affects the reaction [Chlorpyrifos results in increased expression of ACHE mRNA alternative form]; MF63 compound affects the reaction [Chlorpyrifos affects the activity of GSK3B protein]PMID:33930485 PMID:34424684
Gsk3bmultiple interactionsISOGsk3b (Mus musculus)6480464CTD[APOE protein results in increased susceptibility to Chlorpyrifos] which results in decreased phosphorylation of GSK3B protein; GSK3B protein affects the reaction [Chlorpyrifos results in increased phosphorylation of MAPT protein]PMID:29404631 PMID:29665406
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