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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bdecreases expressionISOGsk3b (Mus musculus)6480464CTDNicotine results in decreased expression of GSK3B mRNA; Nicotine results in decreased expression of GSK3B proteinPMID:33640489 PMID:35411647
Gsk3bincreases expressionISOGsk3b (Mus musculus)6480464CTDNicotine results in increased expression of GSK3B mRNAPMID:31945395 PMID:35411647
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTD[Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B proteinPMID:12511591
Gsk3bmultiple interactionsISOGsk3b (Mus musculus)6480464CTDCarbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of GSK3B mRNA]; Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of GSK3B protein]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSK3B mRNA]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSK3B protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in decreased expression of GSK3B mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in decreased expression of GSK3B protein]; Nicotine results in increased expression of and results in decreased phosphorylation of GSK3B proteinPMID:31945395 PMID:33640489 PMID:35411647
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