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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bmultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]PMID:27658547
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTD[Acetylcysteine co-treated with Chlorpyrifos] results in increased activity of GSK3B protein; Acetylcysteine inhibits the reaction [27-hydroxycholesterol inhibits the reaction [GSK3B protein binds to CTNNB1 protein]]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol inhibits the reaction [YWHAH protein binds to GSK3B protein]]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of GSK3B protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of GSK3B protein]; Acetylcysteine inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]; Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased phosphorylation of GSK3B protein]PMID:24968063 PMID:25246272 PMID:33131013 PMID:33930485
Gsk3bmultiple interactionsISOGsk3b (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]; Acetylcysteine inhibits the reaction [Chromium results in decreased phosphorylation of GSK3B protein]PMID:18569013 PMID:19126599
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