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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3baffects expressionISOGSK3B (Homo sapiens)6480464CTDTretinoin affects the expression of GSK3B mRNAPMID:15498508
Gsk3bdecreases phosphorylationISOGsk3b (Mus musculus)6480464CTDTretinoin results in decreased phosphorylation of GSK3B proteinPMID:16288212
Gsk3bincreases expressionISOGSK3B (Homo sapiens)6480464CTDTretinoin results in increased expression of GSK3B mRNAPMID:33167477
Gsk3bincreases phosphorylationISOGSK3B (Homo sapiens)6480464CTDTretinoin results in increased phosphorylation of GSK3B proteinPMID:25614230
Gsk3bincreases phosphorylationISOGsk3b (Mus musculus)6480464CTDTretinoin results in increased phosphorylation of GSK3B proteinPMID:16288212
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTDnickel chloride promotes the reaction [Tretinoin results in increased phosphorylation of GSK3B protein]PMID:25614230
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