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ONTOLOGY REPORT - ANNOTATIONS

Term:pteridine-containing compound metabolic process
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Accession:GO:0042558 term browser browse the term
Definition:The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.
Synonyms:exact_synonym: pteridine and derivative metabolic process;   pteridine and derivative metabolism;   pteridine-containing compound metabolism
 narrow_synonym: pterin metabolic process;   pterin metabolism
 alt_id: GO:0019721


show annotations for term's descendants           Sort by:
pteridine-containing compound metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
10-formyltetrahydrofolate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO
IEA		 (PMID:1881876)
(PMID:23704330)
GO_REF:0000107		 RGD
Ensembl		 PMID:1881876 PMID:23704330 GO_REF:0000107 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like involved_in ISO
IBA		 (PMID:12937168)
GO_REF:0000033		 RGD
GO_Central		 PMID:12937168 GO_REF:0000033 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905 		JBrowse link
10-formyltetrahydrofolate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aasdhppt aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase acts_upstream_of_positive_effect
involved_in		 ISO
IEA		 (PMID:19933275), (PMID:21238436)
GO_REF:0000107		 RGD
Ensembl		 PMID:19933275 PMID:21238436 GO_REF:0000107 NCBI chr 8:1,453,226...1,463,990
Ensembl chr 8:1,452,282...1,463,966 		JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 involved_in ISO
IEA
IMP
IDA		 (PMID:19933275)
(PMID:31624291)
GO_REF:0000117
PMID:10585460
PMID:1848231		 RGD
UniProt		 PMID:19933275 PMID:31624291 PMID:10585460 PMID:1848231 GO_REF:0000117, RGD:150521656, RGD:632027 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 involved_in ISO (PMID:21238436)
(PMID:33168096)		 RGD PMID:21238436 PMID:33168096 NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776 		JBrowse link
10-formyltetrahydrofolate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like IDA RGD PMID:21163947 RGD:7244288 NCBI chr14:17,089,947...17,170,036
Ensembl chr14:17,089,952...17,170,112 		JBrowse link
dihydrobiopterin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gch1 GTP cyclohydrolase 1 IDA RGD PMID:2557335 PMID:8486153 PMID:8702680 RGD:2298653, RGD:2298654, RGD:728623 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
dihydrofolate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IDA RGD PMID:8948466 RGD:5144056 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889 		JBrowse link
G Dhfr dihydrofolate reductase involved_in IDA
IBA
ISO		 GO_REF:0000033
(PMID:2303423), (PMID:23707606)		 GO_Central
RGD		 PMID:2303423 PMID:23707606 PMID:11502523 PMID:3970530 GO_REF:0000033, RGD:1298877, RGD:2300196 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
folic acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfs methenyltetrahydrofolate synthetase involved_in ISO (PMID:12764149) RGD PMID:12764149 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
G Pm20d2 peptidase M20 domain containing 2 NOT|involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:47,566,059...47,586,334
Ensembl chr 5:47,566,072...47,586,212 		JBrowse link
folic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 involved_in IDA PMID:1848231 UniProt PMID:1848231 RGD:632027 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 involved_in ISO (PMID:33168096) RGD PMID:33168096 NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776 		JBrowse link
G Dhfr dihydrofolate reductase involved_in IDA
IBA		 PMID:20424322
GO_REF:0000033		 GO_Central PMID:20424322 GO_REF:0000033, RGD:10054082 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Folr1 folate receptor alpha acts_upstream_of_or_within ISO MGI:2383986 (PMID:12854656) RGD PMID:12854656 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISS
ISO		 GO_REF:0000024
(PMID:24074862)
(PMID:11466310)		 UniProt
RGD		 PMID:11466310 PMID:24074862 GO_REF:0000024 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in ISO (PMID:11278996) RGD PMID:11278996 NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
folic acid-containing compound biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfs methenyltetrahydrofolate synthetase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
folic acid-containing compound metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Folh1 folate hydrolase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:11210180)		 Ensembl
RGD		 PMID:11210180 GO_REF:0000107 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379 		JBrowse link
G Fpgs folylpolyglutamate synthase involved_in ISO (PMID:3619447) RGD PMID:3619447 NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like involved_in ISO (PMID:12937168) RGD PMID:12937168 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905 		JBrowse link
pteridine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spr sepiapterin reductase acts_upstream_of_or_within ISO MGI:3757641 (PMID:16532389) RGD PMID:16532389 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678 		JBrowse link
pteridine-containing compound biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gch1 GTP cyclohydrolase 1 involved_in ISO (PMID:15721862), (PMID:2463916), (PMID:3753653) RGD PMID:2463916 PMID:3753653 PMID:15721862 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
tetrahydrobiopterin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase involved_in ISO (PMID:23707606)
(PMID:19666465)		 RGD PMID:19666465 PMID:23707606 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in ISO
IBA
IEA		 (PMID:17101830), (PMID:19666465), (PMID:7678411), (PMID:9445252)
GO_REF:0000033
GO_REF:0000043		 RGD
GO_Central
UniProt		 PMID:7678411 PMID:9445252 PMID:17101830 PMID:19666465 GO_REF:0000033 GO_REF:0000043 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Pcbd1 pterin-4 alpha-carbinolamine dehydratase 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:29,037,545...29,044,322
Ensembl chr20:28,953,864...29,044,292
Ensembl chr20:28,953,864...29,044,292 		JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:8,845,161...8,896,343
Ensembl chr17:8,845,084...8,910,539 		JBrowse link
G Pts 6-pyruvoyl-tetrahydropterin synthase acts_upstream_of_or_within
involved_in		 TAS
ISO
IEA		 (PMID:9894812)
GO_REF:0000041		 RGD
UniProt		 PMID:9894812 PMID:1939130 GO_REF:0000041, RGD:68294 NCBI chr 8:50,870,838...50,877,869
Ensembl chr 8:50,870,841...50,877,869 		JBrowse link
G Qdpr quinoid dihydropteridine reductase involved_in TAS
IBA
IEA
IMP
IDA		 GO_REF:0000033
GO_REF:0000043
PMID:1898002		 GO_Central
UniProt
RGD		 PMID:3680258 PMID:1898002 PMID:9235988 PMID:660556 GO_REF:0000033 GO_REF:0000043, RGD:729701, RGD:8553309, RGD:5128582, RGD:4139903 NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854 		JBrowse link
G Spr sepiapterin reductase involved_in TAS
IBA
IMP		 GO_REF:0000033 GO_Central
RGD		 PMID:2201030 PMID:2179471 GO_REF:0000033, RGD:70022, RGD:1600056 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678 		JBrowse link
G Spr-ps1 sepiapterin reductase, pseudogene 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:117,689,458...117,693,286
Ensembl chr 4:117,689,458...117,692,891 		JBrowse link
G Txndc15 thioredoxin domain containing 15 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:8,898,074...8,910,538
Ensembl chr17:8,845,084...8,910,539
Ensembl chr 7:8,845,084...8,910,539 		JBrowse link
tetrahydrobiopterin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spr sepiapterin reductase acts_upstream_of_or_within ISO MGI:3757641 (PMID:16532389) RGD PMID:16532389 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678 		JBrowse link
tetrahydrofolate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 TAS RGD PMID:14729668 RGD:1547843 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IDA RGD PMID:7057182 RGD:2301991 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889 		JBrowse link
G Dhfr dihydrofolate reductase involved_in IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:2303423)
GO_REF:0000041		 GO_Central
RGD
UniProt		 PMID:2303423 PMID:11502523 GO_REF:0000033 GO_REF:0000041, RGD:1298877 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
tetrahydrofolate interconversion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase involved_in ISO (PMID:360074) RGD PMID:360074 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Dmgdh dimethylglycine dehydrogenase IDA RGD PMID:6163778 RGD:7245485 NCBI chr 2:24,912,600...24,987,533
Ensembl chr 2:24,912,578...24,987,528 		JBrowse link
G ENSRNOG00000065410 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 Ensembl chr 2:178,497,468...178,499,169 JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in IEA
ISO
IBA
ISS		 GO_REF:0000041
(PMID:23704330)
GO_REF:0000033
GO_REF:0000024
(PMID:10828945), (PMID:1881876)		 UniProt
RGD
GO_Central		 PMID:1881876 PMID:10828945 PMID:23704330 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like involved_in IDA
IBA
IEA		 GO_REF:0000033
PMID:24733394
GO_REF:0000041		 GO_Central
UniProt
RGD		 PMID:21163947 PMID:24733394 GO_REF:0000033 GO_REF:0000041, RGD:7244288, RGD:150521648 NCBI chr14:17,089,947...17,170,036
Ensembl chr14:17,089,952...17,170,112 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase involved_in IEA
IBA
ISO		 GO_REF:0000041
GO_REF:0000033
UniProtKB:P53128 (PMID:10551815), (PMID:12673793), (PMID:25736335), (PMID:29891918)		 UniProt
GO_Central
RGD		 PMID:10551815 PMID:12673793 PMID:25736335 PMID:29891918 GO_REF:0000033 GO_REF:0000041 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mthfs methenyltetrahydrofolate synthetase involved_in ISO
IBA		 (PMID:12764149)
GO_REF:0000033		 RGD
GO_Central		 PMID:12764149 GO_REF:0000033 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
G Sardh sarcosine dehydrogenase IDA RGD PMID:6163778 RGD:7245485 NCBI chr 3:10,510,553...10,575,342
Ensembl chr 3:10,510,553...10,573,874 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in IEA
ISO		 GO_REF:0000041
MGI:1277989 (PMID:19513116)
(PMID:24698160)		 UniProt
RGD		 PMID:19513116 PMID:24698160 GO_REF:0000041 NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 involved_in IEA
ISO		 GO_REF:0000041
MGI:98299 (PMID:19513116)		 UniProt
RGD		 PMID:19513116 GO_REF:0000041 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236 		JBrowse link
G Tyms thymidylate synthetase involved_in ISO (PMID:15093541)
(PMID:22057276)		 RGD PMID:15093541 PMID:22057276 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
tetrahydrofolate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase involved_in ISO
ISS		 (PMID:12096917), (PMID:21876184)
GO_REF:0000024		 RGD
UniProt		 PMID:12096917 PMID:21876184 GO_REF:0000024 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 TAS RGD PMID:2186031 RGD:1299513 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase involved_in ISO (PMID:8218174) RGD PMID:8218174 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase IDA RGD PMID:11730351 RGD:1601423 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mthfs methenyltetrahydrofolate synthetase involved_in ISO (PMID:19738041), (PMID:7766710) RGD PMID:7766710 PMID:19738041 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in IDA
IBA
IMP		 GO_REF:0000033 GO_Central
RGD		 PMID:11730351 PMID:21121936 GO_REF:0000033, RGD:1601423, RGD:7207080 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in ISO
IBA		 (PMID:24698160)
GO_REF:0000033		 RGD
GO_Central		 PMID:24698160 GO_REF:0000033 NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 involved_in ISO
IBA		 (PMID:24075985), (PMID:25619277)
GO_REF:0000033		 RGD
GO_Central		 PMID:24075985 PMID:25619277 GO_REF:0000033 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236 		JBrowse link
G Tyms thymidylate synthetase IEP 5-formyltetrahydrofolate RGD PMID:7503782 RGD:5133451 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
tetrahydrofolylpolyglutamate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fpgs folylpolyglutamate synthase involved_in IEA
ISO		 GO_REF:0000041
(PMID:3619447), (PMID:8408020)
(PMID:25164808)		 UniProt
RGD		 PMID:3619447 PMID:8408020 PMID:25164808 GO_REF:0000041 NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563 		JBrowse link
tetrahydrofolylpolyglutamate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ggh gamma-glutamyl hydrolase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        pteridine-containing compound metabolic process 32
          dihydrobiopterin metabolic process 1
          dihydropteridine metabolic process 0
          folic acid-containing compound metabolic process + 25
          methanopterin-containing compound metabolic process + 0
          pteridine metabolic process + 1
          pteridine-containing compound biosynthetic process + 15
          pteridine-containing compound catabolic process + 5
          tatiopterin metabolic process + 0
          tetrahydrobiopterin metabolic process + 9
paths to the root