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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrahydrofolate biosynthetic process
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Accession:GO:0046654 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
Synonyms:exact_synonym: tetrahydrofolate anabolism;   tetrahydrofolate biosynthesis;   tetrahydrofolate formation;   tetrahydrofolate synthesis
 xref: MetaCyc:FOLSYN-PWY



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tetrahydrofolate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 TAS RGD PMID:14729668 RGD:1547843 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IDA RGD PMID:7057182 RGD:2301991 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889
JBrowse link
G Dhfr dihydrofolate reductase involved_in IDA
IEA
IBA
ISO
GO_REF:0000041
PMID:21873635
(PMID:2303423)
UniProt
RGD
PMID:2303423 PMID:11502523 PMID:21873635 GO_REF:0000041, RGD:1298877, RGD:13792537 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase IDA RGD PMID:4078017 RGD:2301990 NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125
JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
JBrowse link
10-formyltetrahydrofolate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (PMID:1881876)
(MGI:5503248|PMID:23704330)
RGD PMID:1881876 PMID:23704330 MGI:5503248 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like involved_in ISO (PMID:12937168) RGD PMID:12937168 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    metabolic process 11824
      cellular metabolic process 10719
        cellular modified amino acid metabolic process 203
          folic acid-containing compound metabolic process 29
            folic acid-containing compound biosynthetic process 9
              tetrahydrofolate biosynthetic process 7
                10-formyltetrahydrofolate biosynthetic process 2
Path 2
Term Annotations click to browse term
  biological_process 19497
    metabolic process 11824
      cellular metabolic process 10719
        cellular aromatic compound metabolic process 5635
          pteridine-containing compound metabolic process 35
            pteridine-containing compound biosynthetic process 15
              folic acid-containing compound biosynthetic process 9
                tetrahydrofolate biosynthetic process 7
                  10-formyltetrahydrofolate biosynthetic process 2
paths to the root