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ONTOLOGY REPORT - ANNOTATIONS

Term:tetrahydrobiopterin metabolic process
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Accession:GO:0046146 term browser browse the term
Definition:The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.
Synonyms:exact_synonym: 5,6,7,8-tetrahydrobiopterin metabolic process;   tetrahydrobiopterin metabolism


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tetrahydrobiopterin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spr sepiapterin reductase acts_upstream_of_or_within ISO MGI:3757641 (MGI:3722569|PMID:16532389) RGD PMID:16532389 MGI:3722569 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678 		JBrowse link
tetrahydrobiopterin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase involved_in ISO (PMID:23707606)
(MGI:5645206|PMID:19666465)		 RGD PMID:19666465 PMID:23707606 MGI:5645206 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in ISO
IEA
IBA		 (PMID:17101830), (PMID:19666465), (PMID:7678411), (PMID:9445252)
GO_REF:0000043
PMID:21873635		 RGD
UniProt		 PMID:7678411 PMID:9445252 PMID:17101830 PMID:19666465 PMID:21873635 GO_REF:0000043, RGD:13792537 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Pcbd1 pterin-4 alpha-carbinolamine dehydratase 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:29,037,545...29,044,322
Ensembl chr20:28,953,864...29,044,292
Ensembl chr20:28,953,864...29,044,292 		JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:8,845,161...8,896,343
Ensembl chr17:8,845,084...8,910,539 		JBrowse link
G Pts 6-pyruvoyl-tetrahydropterin synthase acts_upstream_of_or_within
involved_in		 TAS
ISO
IEA		 (MGI:1328867|PMID:9894812)
GO_REF:0000041		 RGD
UniProt		 PMID:9894812 PMID:1939130 GO_REF:0000041 MGI:1328867, RGD:68294 NCBI chr 8:50,870,838...50,877,869
Ensembl chr 8:50,870,841...50,877,869 		JBrowse link
G Qdpr quinoid dihydropteridine reductase involved_in TAS
IBA
IDA
IMP		 PMID:21873635
PMID:1898002		 RGD
GO_Central
UniProt		 PMID:3680258 PMID:21873635 PMID:660556 PMID:9235988 PMID:1898002 RGD:729701, RGD:13792537, RGD:4139903, RGD:5128582, RGD:8553309 NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854 		JBrowse link
G Spr sepiapterin reductase involved_in TAS
IBA
IMP		 PMID:21873635 RGD
GO_Central		 PMID:2201030 PMID:21873635 PMID:2179471 RGD:70022, RGD:13792537, RGD:1600056 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678 		JBrowse link
G Spr-ps1 sepiapterin reductase, pseudogene 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:117,689,458...117,693,286
Ensembl chr 4:117,689,458...117,692,891 		JBrowse link
G Txndc15 thioredoxin domain containing 15 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:8,898,074...8,910,538
Ensembl chr17:8,845,084...8,910,539 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    metabolic process 11538
      cellular metabolic process 10124
        heterocycle metabolic process 5704
          pteridine-containing compound metabolic process 32
            tetrahydrobiopterin metabolic process 9
              tetrahydrobiopterin biosynthetic process 9
              tetrahydrobiopterin catabolic process 0
Path 2
Term Annotations click to browse term
  biological_process 19553
    metabolic process 11538
      organic substance metabolic process 10895
        organic hydroxy compound metabolic process 582
          alcohol metabolic process 374
            polyol metabolic process 112
              diol metabolic process 33
                tetrahydrobiopterin metabolic process 9
                  tetrahydrobiopterin biosynthetic process 9
                  tetrahydrobiopterin catabolic process 0
paths to the root