Pts (6-pyruvoyl-tetrahydropterin synthase) - Rat Genome Database

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Gene: Pts (6-pyruvoyl-tetrahydropterin synthase) Rattus norvegicus
Analyze
Symbol: Pts
Name: 6-pyruvoyl-tetrahydropterin synthase
RGD ID: 68367
Description: Enables 6-pyruvoyltetrahydropterin synthase activity. Predicted to act upstream of or within tetrahydrobiopterin biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia A and phenylketonuria. Orthologous to human PTS (6-pyruvoyltetrahydropterin synthase); PARTICIPATES IN dopa responsive dystonia pathway; Segawa syndrome pathway; folate metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6-pyruvoyl tetrahydrobiopterin synthase; 6-pyruvoyltetrahydropterin synthase; PTP synthase; PTPS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,767,234 - 59,774,265 (-)NCBIGRCr8
mRatBN7.2850,870,838 - 50,877,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,870,841 - 50,877,869 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,376,420 - 56,383,401 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,655,319 - 54,662,300 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,519,589 - 52,526,570 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0854,954,261 - 54,961,271 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl854,954,226 - 54,961,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,551,584 - 53,558,594 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,880,701 - 53,887,711 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1853,899,754 - 53,906,765 (-)NCBI
Celera850,419,474 - 50,426,475 (-)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Purification and cDNA cloning of rat 6-pyruvoyl-tetrahydropterin synthase. Inoue Y, etal., J Biol Chem 1991 Nov 5;266(31):20791-6.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. Hyperphenylalaninemia due to defects in tetrahydrobiopterin metabolism: molecular characterization of mutations in 6-pyruvoyl-tetrahydropterin synthase. Thony B, etal., Am J Hum Genet. 1994 May;54(5):782-92.
Additional References at PubMed
PMID:8137809   PMID:9894812   PMID:10024455   PMID:11591653   PMID:15489334   PMID:16169070   PMID:16189514   PMID:18614015   PMID:21516116   PMID:24599843   PMID:25416956   PMID:25502805  
PMID:25910212   PMID:31515488  


Genomics

Comparative Map Data
Pts
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,767,234 - 59,774,265 (-)NCBIGRCr8
mRatBN7.2850,870,838 - 50,877,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,870,841 - 50,877,869 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,376,420 - 56,383,401 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,655,319 - 54,662,300 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,519,589 - 52,526,570 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0854,954,261 - 54,961,271 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl854,954,226 - 54,961,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,551,584 - 53,558,594 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,880,701 - 53,887,711 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1853,899,754 - 53,906,765 (-)NCBI
Celera850,419,474 - 50,426,475 (-)NCBICelera
Cytogenetic Map8q23NCBI
PTS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811112,226,428 - 112,233,973 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11112,226,367 - 112,269,955 (+)EnsemblGRCh38hg38GRCh38
GRCh3711112,097,151 - 112,104,696 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,602,309 - 111,609,903 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411111,602,308 - 111,609,903NCBI
Celera11109,250,329 - 109,257,937 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11108,022,655 - 108,030,262 (+)NCBIHuRef
CHM1_111111,980,551 - 111,988,158 (+)NCBICHM1_1
T2T-CHM13v2.011112,236,776 - 112,368,893 (+)NCBIT2T-CHM13v2.0
Pts
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,432,917 - 50,440,017 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,432,917 - 50,440,024 (-)EnsemblGRCm39 Ensembl
GRCm38950,521,617 - 50,528,716 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,521,617 - 50,528,724 (-)EnsemblGRCm38mm10GRCm38
MGSCv37950,329,722 - 50,336,746 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,273,847 - 50,280,871 (-)NCBIMGSCv36mm8
Celera947,811,421 - 47,818,445 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.73NCBI
Pts
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,880,937 - 13,888,562 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,880,937 - 13,888,562 (+)NCBIChiLan1.0ChiLan1.0
PTS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,971,384 - 112,978,838 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111114,065,773 - 114,073,257 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011107,107,114 - 107,114,594 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,949,714 - 110,957,599 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,949,708 - 110,957,599 (+)Ensemblpanpan1.1panPan2
PTS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1520,883,128 - 20,912,318 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl520,896,236 - 20,912,297 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,828,713 - 20,835,800 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0520,928,161 - 20,935,247 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl520,919,161 - 20,987,893 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1520,991,102 - 20,998,175 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0520,891,374 - 20,898,446 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0520,917,631 - 20,946,631 (-)NCBIUU_Cfam_GSD_1.0
Pts
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,451,940 - 94,458,598 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,246,878 - 2,253,675 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,247,825 - 2,255,277 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,920,273 - 39,928,634 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,920,157 - 39,927,804 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,771,647 - 44,779,304 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,574,057 - 103,581,944 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,574,451 - 103,582,924 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604322,404,405 - 22,412,377 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pts
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,360,344 - 7,370,042 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247847,360,655 - 7,424,357 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pts
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:231
Count of miRNA genes:157
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000012434
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 8 57 41 19 41 67 35 34 11
Low 35 8 11 7 7 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000012434   ⟹   ENSRNOP00000012434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl850,870,859 - 50,877,869 (-)Ensembl
Rnor_6.0 Ensembl854,954,226 - 54,961,265 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115317   ⟹   ENSRNOP00000089914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl850,870,841 - 50,876,226 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116344   ⟹   ENSRNOP00000090052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl850,870,845 - 50,877,846 (-)Ensembl
RefSeq Acc Id: NM_001409515   ⟹   NP_001396444
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,767,234 - 59,774,265 (-)NCBI
mRatBN7.2850,870,838 - 50,877,869 (-)NCBI
RefSeq Acc Id: NM_001409516   ⟹   NP_001396445
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,767,234 - 59,774,265 (-)NCBI
mRatBN7.2850,870,838 - 50,877,869 (-)NCBI
RefSeq Acc Id: NM_017220   ⟹   NP_058916
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,767,255 - 59,774,265 (-)NCBI
mRatBN7.2850,870,859 - 50,877,869 (-)NCBI
Rnor_6.0854,954,261 - 54,961,271 (-)NCBI
Rnor_5.0853,551,584 - 53,558,594 (-)NCBI
RGSC_v3.4853,880,701 - 53,887,711 (-)RGD
Celera850,419,474 - 50,426,475 (-)RGD
Sequence:
RefSeq Acc Id: NP_058916   ⟸   NM_017220
- Peptide Label: isoform 1
- UniProtKB: P27213 (UniProtKB/Swiss-Prot),   A6J4D4 (UniProtKB/TrEMBL),   A0A8I6AM88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012434   ⟸   ENSRNOT00000012434
RefSeq Acc Id: ENSRNOP00000089914   ⟸   ENSRNOT00000115317
RefSeq Acc Id: ENSRNOP00000090052   ⟸   ENSRNOT00000116344
RefSeq Acc Id: NP_001396445   ⟸   NM_001409516
- Peptide Label: isoform 3
- UniProtKB: A6J4D6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396444   ⟸   NM_001409515
- Peptide Label: isoform 2
- UniProtKB: A6J4D5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27213-F1-model_v2 AlphaFold P27213 1-144 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695943
Promoter ID:EPDNEW_R6468
Type:multiple initiation site
Name:Pts_1
Description:6-pyruvoyl-tetrahydropterin synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0854,961,237 - 54,961,297EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68367 AgrOrtholog
BioCyc Gene G2FUF-30564 BioCyc
Ensembl Genes ENSRNOG00000009250 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055027317 UniProtKB/Swiss-Prot
  ENSRNOG00060015615 UniProtKB/Swiss-Prot
  ENSRNOG00065016807 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012434 ENTREZGENE
  ENSRNOT00000012434.4 UniProtKB/Swiss-Prot
  ENSRNOT00000115317.1 UniProtKB/TrEMBL
  ENSRNOT00000116344.1 UniProtKB/TrEMBL
  ENSRNOT00055047302 UniProtKB/Swiss-Prot
  ENSRNOT00060026755 UniProtKB/Swiss-Prot
  ENSRNOT00065028056 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.479.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6888665 IMAGE-MGC_LOAD
InterPro 6-PTP_synth/QueD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6-PTP_synth/QueD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPS_Cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPS_His_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29498 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72872 IMAGE-MGC_LOAD
NCBI Gene 29498 ENTREZGENE
PANTHER 6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12589 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PTPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PTS RGD
PhenoGen Pts PhenoGen
PIRSF PTP_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PTPS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009250 RatGTEx
  ENSRNOG00055027317 RatGTEx
  ENSRNOG00060015615 RatGTEx
  ENSRNOG00065016807 RatGTEx
Superfamily-SCOP Tetrahydrobiopterin biosynthesis enzymes-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216713
UniProt A0A8I6A899_RAT UniProtKB/TrEMBL
  A0A8I6AM88 ENTREZGENE, UniProtKB/TrEMBL
  A6J4D3_RAT UniProtKB/TrEMBL
  A6J4D4 ENTREZGENE, UniProtKB/TrEMBL
  A6J4D5 ENTREZGENE, UniProtKB/TrEMBL
  A6J4D6 ENTREZGENE, UniProtKB/TrEMBL
  P27213 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pts  6-pyruvoyl-tetrahydropterin synthase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference