Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase) Rattus norvegicus
Analyze
Symbol: Mtrr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
RGD ID: 1308671
Description: Predicted to have several functions, including NADPH-hemoprotein reductase activity; nucleotide binding activity; and oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor. Predicted to be involved in several processes, including folic acid metabolic process; negative regulation of cystathionine beta-synthase activity; and sulfur amino acid metabolic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); homocystinuria; and ulcerative colitis. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: aqCbl reductase; aquacobalamin reductase; LOC290947; methionine synthase reductase; MGC112912; MSR
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0137,743,089 - 37,774,485 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl137,743,147 - 37,774,015 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0139,124,730 - 39,156,109 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4175,086,219 - 5,118,086 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1175,087,203 - 5,117,405 (+)NCBI
Celera133,436,562 - 33,468,429 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Mtrr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308671
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-09-01
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.