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ONTOLOGY REPORT - ANNOTATIONS

Term:folic acid-containing compound metabolic process
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Accession:GO:0006760 term browser browse the term
Definition:The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.
Synonyms:exact_synonym: folate and derivative metabolic process;   folate and derivative metabolism;   folate-containing compound metabolic process;   folate-containing compound metabolism;   folic acid and derivative metabolic process;   folic acid and derivative metabolism;   folic acid-containing compound metabolism;   vitamin B9 and derivative metabolic process;   vitamin B9 and derivative metabolism;   vitamin M and derivative metabolic process;   vitamin M and derivative metabolism


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folic acid-containing compound metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Folh1 folate hydrolase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:1934060|PMID:11210180)		 Ensembl
RGD		 PMID:11210180 GO_REF:0000107 MGI:1934060 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379 		JBrowse link
G Fpgs folylpolyglutamate synthase involved_in ISO (PMID:3619447) RGD PMID:3619447 NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like involved_in ISO (PMID:12937168) RGD PMID:12937168 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905 		JBrowse link
10-formyltetrahydrofolate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (PMID:1881876)
(MGI:5503248|PMID:23704330)		 RGD PMID:1881876 PMID:23704330 MGI:5503248 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like involved_in ISO (PMID:12937168) RGD PMID:12937168 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905 		JBrowse link
10-formyltetrahydrofolate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aasdhppt aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase acts_upstream_of_positive_effect ISO (PMID:19933275), (PMID:21238436) RGD PMID:19933275 PMID:21238436 NCBI chr 8:1,453,226...1,463,990
Ensembl chr 8:1,452,282...1,463,966 		JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 involved_in IEA
IMP
ISO
IDA		 GO_REF:0000104
PMID:10585460
(MGI:6369507|PMID:31624291)
PMID:1848231
(PMID:19933275)		 UniProt
RGD		 PMID:19933275 PMID:31624291 PMID:10585460 PMID:1848231 GO_REF:0000104 MGI:6369507, RGD:150521656, RGD:632027 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 involved_in ISO (PMID:21238436)
(MGI:6489626|PMID:33168096)		 RGD PMID:21238436 PMID:33168096 MGI:6489626 NCBI chr 7:20,254,196...20,305,793
Ensembl chr 7:20,254,233...20,305,776 		JBrowse link
10-formyltetrahydrofolate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like IDA RGD PMID:21163947 RGD:7244288 NCBI chr14:17,089,947...17,170,036
Ensembl chr14:17,089,952...17,170,112 		JBrowse link
dihydrofolate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IDA RGD PMID:8948466 RGD:5144056 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889 		JBrowse link
G Dhfr dihydrofolate reductase involved_in IDA
IBA
ISO		 PMID:21873635
(PMID:2303423), (PMID:23707606)		 RGD PMID:2303423 PMID:23707606 PMID:11502523 PMID:21873635 PMID:3970530 RGD:1298877, RGD:13792537, RGD:2300196 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
folic acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfs methenyltetrahydrofolate synthetase involved_in ISO (PMID:12764149) RGD PMID:12764149 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
G Pm20d2 peptidase M20 domain containing 2 NOT|involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:47,566,059...47,586,334
Ensembl chr 5:47,566,072...47,586,212 		JBrowse link
folic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 involved_in IDA PMID:1848231 UniProt PMID:1848231 RGD:632027 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 involved_in ISO (MGI:6489626|PMID:33168096) RGD PMID:33168096 MGI:6489626 NCBI chr 7:20,254,196...20,305,793
Ensembl chr 7:20,254,233...20,305,776 		JBrowse link
G Dhfr dihydrofolate reductase involved_in IBA
IDA		 PMID:21873635
PMID:20424322		 GO_Central
BHF-UCL		 PMID:21873635 PMID:20424322 RGD:13792537, RGD:10054082 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Folr1 folate receptor alpha acts_upstream_of_or_within ISO MGI:2383986 (MGI:2669340|PMID:12854656) RGD PMID:12854656 MGI:2669340 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667 		JBrowse link
G Gnmt glycine N-methyltransferase TAS RGD PMID:12054489 RGD:728472 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO
ISS		 (PMID:11466310)
GO_REF:0000024
(MGI:5512657|PMID:24074862)		 RGD
UniProt		 PMID:11466310 PMID:24074862 GO_REF:0000024 MGI:5512657 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in IBA
ISO		 PMID:21873635
(PMID:11278996)		 RGD PMID:11278996 PMID:21873635 RGD:13792537 NCBI chr10:45,468,698...45,497,820
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236 		JBrowse link
folic acid-containing compound biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fpgs folylpolyglutamate synthase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563 		JBrowse link
G Mthfs methenyltetrahydrofolate synthetase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
tetrahydrofolate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 TAS RGD PMID:14729668 RGD:1547843 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IDA RGD PMID:7057182 RGD:2301991 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889 		JBrowse link
G Dhfr dihydrofolate reductase involved_in IDA
IEA
IBA
ISO		 GO_REF:0000041
PMID:21873635
(PMID:2303423)		 UniProt
RGD		 PMID:2303423 PMID:11502523 PMID:21873635 GO_REF:0000041, RGD:1298877, RGD:13792537 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase IDA RGD PMID:4078017 RGD:2301990 NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125 		JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
tetrahydrofolate interconversion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase involved_in ISO (MGI:67444|PMID:360074) RGD PMID:360074 MGI:67444 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Dmgdh dimethylglycine dehydrogenase IDA RGD PMID:6163778 RGD:7245485 NCBI chr 2:24,912,600...24,987,533
Ensembl chr 2:24,912,578...24,987,528 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in IEA
ISS
ISO
IBA		 GO_REF:0000041
GO_REF:0000024
(PMID:10828945), (PMID:1881876)
(MGI:5503248|PMID:23704330)
PMID:21873635		 UniProt
RGD		 PMID:1881876 PMID:10828945 PMID:23704330 PMID:21873635 GO_REF:0000024 GO_REF:0000041 MGI:5503248, RGD:13792537 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like involved_in IBA
IEA		 PMID:21873635
GO_REF:0000041		 UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like involved_in IDA
IEA
IBA		 PMID:24733394
GO_REF:0000041
PMID:21873635		 UniProt
RGD		 PMID:21163947 PMID:24733394 PMID:21873635 GO_REF:0000041, RGD:7244288, RGD:150521648, RGD:13792537 NCBI chr14:17,089,947...17,170,036
Ensembl chr14:17,089,952...17,170,112 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase involved_in IEA
ISO
IBA		 GO_REF:0000041
UniProtKB:P53128 (PMID:10551815), (PMID:12673793), (PMID:25736335), (PMID:29891918)
PMID:21873635		 UniProt
RGD		 PMID:10551815 PMID:12673793 PMID:25736335 PMID:29891918 PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mthfs methenyltetrahydrofolate synthetase involved_in ISO
IBA		 (PMID:12764149)
PMID:21873635		 RGD PMID:12764149 PMID:21873635 RGD:13792537 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
G Sardh sarcosine dehydrogenase IDA RGD PMID:6163778 RGD:7245485 NCBI chr 3:10,510,553...10,575,342
Ensembl chr 3:10,510,553...10,573,874 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in IEA
IBA
ISO		 GO_REF:0000041
PMID:21873635
MGI:1277989 (MGI:3849912|PMID:19513116)
(PMID:24698160)		 UniProt
RGD		 PMID:19513116 PMID:24698160 PMID:21873635 GO_REF:0000041 MGI:3849912, RGD:13792537 NCBI chr10:45,468,698...45,497,820
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 involved_in IEA
IBA
ISO		 GO_REF:0000041
PMID:21873635
MGI:98299 (MGI:3849912|PMID:19513116)		 UniProt
RGD		 PMID:19513116 PMID:21873635 GO_REF:0000041 MGI:3849912, RGD:13792537 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236 		JBrowse link
G Tyms thymidylate synthetase involved_in ISO (PMID:15093541)
(MGI:5300404|PMID:22057276)		 RGD PMID:15093541 PMID:22057276 MGI:5300404 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
tetrahydrofolate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase involved_in ISO
ISS		 (PMID:12096917), (PMID:21876184)
GO_REF:0000024		 RGD
UniProt		 PMID:12096917 PMID:21876184 GO_REF:0000024 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 TAS RGD PMID:2186031 RGD:1299513 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase involved_in ISO (PMID:8218174) RGD PMID:8218174 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase IDA RGD PMID:11730351 RGD:1601423 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mthfs methenyltetrahydrofolate synthetase involved_in ISO (PMID:19738041), (PMID:7766710) RGD PMID:7766710 PMID:19738041 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IDA
IMP		 RGD PMID:11730351 PMID:21121936 RGD:1601423, RGD:7207080 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in ISO
IBA		 (PMID:24698160)
PMID:21873635		 RGD PMID:24698160 PMID:21873635 RGD:13792537 NCBI chr10:45,468,698...45,497,820
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 involved_in ISO
IBA		 (PMID:24075985), (PMID:25619277)
PMID:21873635		 RGD PMID:24075985 PMID:25619277 PMID:21873635 RGD:13792537 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236 		JBrowse link
G Tyms thymidylate synthetase IEP 5-formyltetrahydrofolate RGD PMID:7503782 RGD:5133451 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
tetrahydrofolylpolyglutamate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fpgs folylpolyglutamate synthase involved_in IBA
IEA
ISO		 PMID:21873635
GO_REF:0000041
(PMID:3619447)
(PMID:25164808)		 UniProt
RGD		 PMID:3619447 PMID:25164808 PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563 		JBrowse link
tetrahydrofolylpolyglutamate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ggh gamma-glutamyl hydrolase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    cellular process 17432
      cellular metabolic process 9699
        cellular modified amino acid metabolic process 197
          folic acid-containing compound metabolic process 26
            dihydrofolate metabolic process + 2
            folic acid metabolic process + 10
            folic acid-containing compound biosynthetic process + 9
            folic acid-containing compound catabolic process + 5
            tetrahydrofolate metabolic process + 19
            tetrahydrofolylpolyglutamate metabolic process + 2
Path 2
Term Annotations click to browse term
  biological_process 18737
    cellular process 17432
      cellular metabolic process 9699
        cellular aromatic compound metabolic process 5557
          pteridine-containing compound metabolic process 32
            folic acid-containing compound metabolic process 26
              dihydrofolate metabolic process + 2
              folic acid metabolic process + 10
              folic acid-containing compound biosynthetic process + 9
              folic acid-containing compound catabolic process + 5
              tetrahydrofolate metabolic process + 19
              tetrahydrofolylpolyglutamate metabolic process + 2
paths to the root