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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Albuminuria
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Accession:DOID:9001542 term browser browse the term
Definition:The presence of albumin in the urine, an indicator of KIDNEY DISEASES.
Synonyms:exact_synonym: Albuminurias
 primary_id: MESH:D000419
 xref: EFO:0004285


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Albuminuria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme treatment ISO associated with Diabetes Mellitus, Type 1;protein:increased activity:serum (human)
associated with Diabetic Nephropathies
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:1336356 PMID:16902320 PMID:23733546 RGD:12879427 RGD:7829770 NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358 		JBrowse link
G ADM adrenomedullin ISO associated with Hypertension RGD PMID:19424162 RGD:2313311 NCBI chr21:33,472,197...33,474,472
Ensembl chr21:33,471,623...33,474,495 		JBrowse link
G AGER advanced glycosylation end-product specific receptor treatment ISO associated with Diabetes Mellitus, Experimental
associated with Diabetic Nephropathies
associated with Diabetes Mellitus, Type 2; protein:increased expression:serum (human)		 RGD PMID:20627935 PMID:21607631 PMID:21796806 RGD:7243944 RGD:7244135 RGD:7244184 NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129 		JBrowse link
G AGT angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:12414515 PMID:18679781 PMID:21896938 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B ISO associated with Diabetes Mellitus, Experimental;human gene in a rat model RGD PMID:12166624 RGD:8548813 NCBI chr14:2,991,888...3,006,941
Ensembl chr14:2,991,888...3,006,940 		JBrowse link
G ALB albumin ISO associated with hypertension
associated with Diabetes Mellitus, Insulin-Dependent		 RGD PMID:15102963 PMID:19414946 RGD:1601157 RGD:2306884 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO associated with Diabetes Mellitus, Non-Insulin-Dependent; DNA:polymorphism:cds:p.R261Q (human) RGD PMID:18640486 RGD:2313875 NCBI chr 5:32,026,193...32,038,698
Ensembl chr 5:31,882,501...32,038,119 		JBrowse link
G B2M beta-2-microglobulin ISO associated with HIV infections;protein:increased expression:urine RGD PMID:18469311 RGD:6482713 NCBI chr30:11,331,574...11,337,991
Ensembl chr30:11,331,569...11,337,997 		JBrowse link
G CASR calcium sensing receptor ISO associated with Uremia RGD PMID:19188910 RGD:7205661 NCBI chr33:25,340,822...25,432,814
Ensembl chr33:25,405,846...25,432,559 		JBrowse link
G CCL4 chemokine (C-C motif) ligand 4 ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:urine RGD PMID:21113841 RGD:5683918 NCBI chr 9:37,681,342...37,682,691
Ensembl chr 9:37,676,966...37,710,209 		JBrowse link
G CD38 CD38 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:21992601 NCBI chr 3:64,529,129...64,577,755
Ensembl chr 3:64,529,721...64,578,099 		JBrowse link
G CIITA class II major histocompatibility complex transactivator ISO DNA:polymorphism:promoter:-168A>G, in non-diabetic subjects RGD PMID:17183695 RGD:5491201 NCBI chr 6:31,774,486...31,837,025
Ensembl chr 6:31,774,609...31,836,820 		JBrowse link
G CP ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:21752484 NCBI chr23:43,969,297...44,033,226
Ensembl chr23:43,969,435...44,030,369 		JBrowse link
G CRP C-reactive protein severity ISO associated with Anemia, Sickle Cell; protein:increased expression:serum
associated with hypertension		 RGD PMID:20016210 PMID:20710104 RGD:6907441 RGD:6909147 NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166 		JBrowse link
G CSF1 colony stimulating factor 1 treatment ISO associated with Hypercholesterolemia and Diabetes Mellitus, Experimental RGD PMID:8573750 RGD:7257591 NCBI chr 6:42,028,454...42,047,028
Ensembl chr 6:42,034,149...42,049,371 		JBrowse link
G CTSB cathepsin B ISO associated with Hypertension RGD PMID:19023196 RGD:2315726 NCBI chr25:26,048,237...26,056,570
Ensembl chr25:26,048,253...26,055,801 		JBrowse link
G CTSL3 cathepsin L family member 3 ISO associated with Hypertension RGD PMID:19023196 RGD:2315726 NCBI chr 1:72,215,774...72,219,093 JBrowse link
G DRD1 dopamine receptor D1 ISO DNA:polymorphism:5' utr:g.-94G>A rs5326 (human) RGD PMID:17353515 RGD:7248452 NCBI chr 4:37,550,454...37,554,641
Ensembl chr 4:37,549,708...37,553,287 		JBrowse link
G EDN1 endothelin 1 ISO protein:increased expression:renal papilla (rat) RGD PMID:20666571 RGD:4144838 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383 		JBrowse link
G EPO erythropoietin ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression:urine,serum RGD PMID:16921186 RGD:2313841 NCBI chr 6:8,994,211...8,995,954
Ensembl chr 6:8,994,211...8,996,144 		JBrowse link
G F7 coagulation factor VII no_association
severity		 ISO associated with Diabetes Mellitus, Insulin-Dependent; protein:increased activity:plasma (human)
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased activity:plasma (human)		 RGD PMID:8250495 PMID:8458188 PMID:9187410 RGD:2312406 RGD:2312407 RGD:2312410 NCBI chr22:60,572,459...60,582,743
Ensembl chr22:60,571,822...60,597,024 		JBrowse link
G FBN1 fibrillin 1 ISO associated with Hypertension RGD PMID:16380460 RGD:7365080 NCBI chr30:14,640,973...14,864,151
Ensembl chr30:14,640,973...14,864,151 		JBrowse link
G GGT1 gamma-glutamyltransferase 1 ISO associated with Diabetes Mellitus; protein:increased activity:serum RGD PMID:15890893 RGD:2315606 NCBI chr26:28,301,455...28,315,029 JBrowse link
G GNAQ G protein subunit alpha q ISO CTD Direct Evidence: marker/mechanism CTD PMID:16267159 NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065 		JBrowse link
G GPC5 glypican 5 ISO CTD Direct Evidence: therapeutic CTD PMID:21441931 NCBI chr22:42,526,426...43,873,992
Ensembl chr22:42,526,054...43,870,405 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO associated with Anemia, Sickle Cell;protein:increased expression:urine: RGD PMID:21630304 RGD:7245982 NCBI chr 4:53,012,223...53,066,611
Ensembl chr 4:53,046,970...53,128,952
Ensembl chr 4:53,046,970...53,128,952 		JBrowse link
G IGF1 insulin like growth factor 1 susceptibility ISO RGD PMID:16645019 RGD:1598420 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794 		JBrowse link
G IL1B interleukin 1 beta ISO RGD PMID:23103566 RGD:7175089 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17167242 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G INS insulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:9861226 PMID:29420703 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
G LEPR leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:17065336 PMID:20175764 PMID:23159718 PMID:28130181 PMID:29988851 NCBI chr 5:44,684,118...44,775,626
Ensembl chr 5:44,688,109...44,775,636 		JBrowse link
G LIPC lipase C, hepatic type ISO associated with Diabetes Mellitus, Insulin-Dependent; protein:increased expression:plasma (human) RGD PMID:8666151 RGD:2308836 NCBI chr30:23,432,460...23,584,037
Ensembl chr30:23,432,493...23,584,037 		JBrowse link
G LOC607874 cystatin-C-like ISO associated with Diabetes Mellitus, Non-Insulin Dependent; protein:increased expression:serum (human) RGD PMID:19596469 RGD:2314309 NCBI chr23:49,562...53,618 JBrowse link
G LRP2 LDL receptor related protein 2 ISO RGD PMID:12121845 RGD:1641839 NCBI chr36:13,910,450...14,107,081
Ensembl chr36:13,911,865...14,107,546 		JBrowse link
G MIR130A microRNA mir-130a ISO CTD Direct Evidence: marker/mechanism CTD PMID:24223694 NCBI chr18:38,543,618...38,543,679
Ensembl chr18:38,543,618...38,543,681 		JBrowse link
G MIR145 microRNA mir-145 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24223694 NCBI chr 4:59,533,128...59,533,210
Ensembl chr 4:59,533,128...59,533,210 		JBrowse link
G MIR155 microRNA mir-155 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24223694 NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833 		JBrowse link
G MIR424 microRNA mir-424 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24223694 NCBI chr  X:105,183,437...105,183,493
Ensembl chr  X:105,183,437...105,183,493 		JBrowse link
G MMP9 matrix metallopeptidase 9 onset ISO associated with Diabetes Mellitus, Type 2; protein:increased expression:plasma (human) RGD PMID:9774113 RGD:7207214 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase susceptibility ISO associated with Diabetes Mellitus, Type 2; DNA:transition, transversion:cds:g.677C>T, g.1298A>C (human) RGD PMID:22554825 RGD:6893631 NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818 		JBrowse link
G MYH9 myosin heavy chain 9 ISO associated with hypertension;DNA:SNPs: : RGD PMID:19153477 RGD:6903241 NCBI chr10:28,063,626...28,122,953
Ensembl chr10:28,063,624...28,122,953 		JBrowse link
G NCK1 NCK adaptor protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19443634 NCBI chr23:33,297,660...33,374,025
Ensembl chr23:33,297,756...33,372,534 		JBrowse link
G NCK2 NCK adaptor protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19443634 NCBI chr10:37,584,351...37,734,388
Ensembl chr10:37,585,565...37,732,994 		JBrowse link
G NPHS1 NPHS1 adhesion molecule, nephrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15684566 NCBI chr 1:116,794,891...116,814,418
Ensembl chr 1:116,794,433...116,813,546 		JBrowse link
G NPHS2 NPHS2 stomatin family member, podocin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15684566 NCBI chr 7:20,347,526...20,375,975
Ensembl chr 7:20,354,134...20,374,020 		JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 ISO compared to FHH RGD PMID:24722447 RGD:12910103 NCBI chr27:2,947,729...2,965,045
Ensembl chr27:2,891,053...2,955,655 		JBrowse link
G PDPN podoplanin ISO RGD PMID:18199599 RGD:2292240 NCBI chr 2:83,552,735...83,581,375
Ensembl chr 2:83,552,830...83,581,375 		JBrowse link
G PON1 paraoxonase 1 ISO DNA:polymorphisms:promoter, cds (human) RGD PMID:16949520 RGD:2313272 NCBI chr14:20,565,620...20,600,774
Ensembl chr14:20,565,641...20,642,985 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha ISO associated with Diabetes Mellitus, Type 2; DNA:snp:cds:g.75919G>A rs8192678 (human) RGD PMID:22684233 RGD:7242025 NCBI chr 3:85,645,942...86,284,570
Ensembl chr 3:86,016,140...86,281,269 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17890881 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903 		JBrowse link
G PTH parathyroid hormone ISO associated with Renal Insufficiency, Chronic; protein:increased expression:serum (human) RGD PMID:23066118 RGD:7242730 NCBI chr21:36,417,062...36,419,967
Ensembl chr21:36,417,058...36,419,967 		JBrowse link
G PYCARD PYD and CARD domain containing ISO CTD Direct Evidence: marker/mechanism CTD PMID:22647887 NCBI chr 6:17,049,352...17,051,348
Ensembl chr 6:17,049,705...17,051,240 		JBrowse link
G RAB38 RAB38, member RAS oncogene family ISO compared to FHH-Tg(CAG-Rab38)1Mcwi, FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi RGD PMID:15758045 PMID:23291471 RGD:1357409 RGD:13782139 NCBI chr21:11,769,924...11,823,546
Ensembl chr21:11,769,351...11,822,815 		JBrowse link
G RAG1 recombination activating 1 ISO RGD PMID:23364523 RGD:7207429 NCBI chr18:31,628,231...31,639,980
Ensembl chr18:31,630,737...31,641,660 		JBrowse link
G REN renin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12414515 PMID:18679781 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
G RETN resistin ISO associated with Hypertension;protein:increased expression:blood RGD PMID:20203628 RGD:7207150 NCBI chr20:52,434,148...52,435,627
Ensembl chr20:52,434,271...52,435,624 		JBrowse link
G SERPINE1 serpin family E member 1 ISO associated with Diabetes Mellitus, Type 1;protein:increased expression:plasma (human) RGD PMID:9201602 RGD:8547710 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301 		JBrowse link
G SERPINF1 serpin family F member 1 treatment ISO associated with Diabetes Mellitus, Experimental; human gene in a rat model RGD PMID:16731830 RGD:8554875 NCBI chr 9:45,891,368...45,902,768
Ensembl chr 9:45,891,410...45,902,765 		JBrowse link
G SH2B3 SH2B adaptor protein 3 ISO RGD PMID:25776069 RGD:13442483 NCBI chr26:9,033,851...9,073,095
Ensembl chr26:9,005,281...9,070,204 		JBrowse link
G SHC1 SHC adaptor protein 1 ameliorates ISO RGD PMID:27270176 RGD:12792230 NCBI chr 7:42,501,829...42,509,613
Ensembl chr 7:42,500,185...42,508,276 		JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17942768 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706 		JBrowse link
G SPP1 secreted phosphoprotein 1 ISO RGD PMID:18443355 RGD:6903862 NCBI chr32:11,354,070...11,362,325
Ensembl chr32:11,353,953...11,362,069 		JBrowse link
G TMEM63C transmembrane protein 63C ISO mRNA:increased expression:kidney,renal glomerulus (rat) RGD PMID:30900988 RGD:15023481 NCBI chr 8:50,000,306...50,076,457
Ensembl chr 8:50,020,823...50,074,060 		JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:17167242 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
G TRPC3 transient receptor potential cation channel subfamily C member 3 ISO associated with Hypertension;mRNA, protein:increased expression:kidney cortex RGD PMID:19887786 RGD:7247603 NCBI chr19:18,207,565...18,272,551
Ensembl chr19:18,207,417...18,271,828 		JBrowse link
G TRPC5 transient receptor potential cation channel subfamily C member 5 ISO RGD PMID:24231357 RGD:10043830 NCBI chr  X:84,835,130...84,989,609
Ensembl chr  X:84,801,096...85,116,625 		JBrowse link
G TRPC6 transient receptor potential cation channel subfamily C member 6 ISO associated with Hypertension;mRNA:decreased expression:kidney cortex RGD PMID:19887786 PMID:21839714 RGD:7247445 RGD:7247603 NCBI chr 5:29,897,378...30,007,885
Ensembl chr 5:29,897,210...30,007,723 		JBrowse link
G TSLP thymic stromal lymphopoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17686814 NCBI chr 3:1,502,469...1,507,696
Ensembl chr 3:1,503,188...1,507,696 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:18299691 RGD:2312766 NCBI chr 6:49,341,669...49,359,841
Ensembl chr 6:49,342,151...49,359,933 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17773
    Pathological Conditions, Signs and Symptoms 12025
      Signs and Symptoms 9902
        Urological Manifestations 411
          proteinuria 380
            Albuminuria 69
Path 2
Term Annotations click to browse term
  disease 17773
    disease of anatomical entity 15149
      Urogenital Diseases 4737
        urinary system disease 2406
          kidney disease 2174
            proteinuria 380
              Albuminuria 69
paths to the root