LIPC (lipase C, hepatic type) - Rat Genome Database

Name: LIPC
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: LIPC (lipase C, hepatic type) Canis lupus familiaris

Analyze

Symbol:

LIPC

Name:

lipase C, hepatic type

RGD ID:

12159133

Description:

ENCODES a protein that exhibits acetylesterase activity (ortholog); acyltransferase activity (ortholog); apolipoprotein binding (ortholog); INVOLVED IN aflatoxin metabolic process (ortholog); cellular response to hormone stimulus (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); Bloom syndrome (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hepatic triacylglycerol lipase; hepatic triglyceride lipase; HTGL

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LIPC (lipase C, hepatic type)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Lipc (lipase, hepatic)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Lipc (lipase C, hepatic type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lipc (lipase C, hepatic type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LIPC (lipase C, hepatic type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lipc (lipase C, hepatic type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LIPC (lipase C, hepatic type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LIPC (lipase C, hepatic type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lipc (lipase C, hepatic type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	23,432,460 - 23,584,037 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	23,432,493 - 23,584,037 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	23,404,560 - 23,555,900 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	23,597,357 - 23,749,167 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	23,597,357 - 23,852,590 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	23,523,240 - 23,674,537 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	23,608,314 - 23,759,924 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	23,750,266 - 23,901,905 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Albuminuria (ISO)

Alzheimer's disease (ISO)

Bloom syndrome (ISO)

Chemical and Drug Induced Liver Injury (ISO)

colorectal cancer (ISO)

coronary artery disease (ISO)

Coronary Disease (ISO)

Dyslipidemias (ISO)

end stage renal disease (ISO)

Experimental Diabetes Mellitus (ISO)

familial combined hyperlipidemia (ISO)

familial hyperlipidemia (ISO)

Fetal Macrosomia (ISO)

focal segmental glomerulosclerosis (ISO)

Hepatic Lipase Deficiency (ISO)

hepatitis (ISO)

Hypercholesterolemia (ISO)

Hyperemia (ISO)

hyperinsulinism (ISO)

Hyperlipoproteinemia Type II (ISO)

Hyperlipoproteinemias (ISO)

Hypertriglyceridemia (ISO)

Hypoproteinemia (ISO)

hypothyroidism (ISO)

Insulin Resistance (ISO)

ischemia (ISO)

kidney disease (ISO)

lipid metabolism disorder (ISO)

maturity-onset diabetes of the young type 1 (ISO)

nephrotic syndrome (ISO)

obesity (ISO)

peripheral vascular disease (ISO)

protein-energy malnutrition (ISO)

Sepsis (ISO)

type 1 diabetes mellitus (ISO)

type 1 diabetes mellitus 2 (ISO)

type 2 diabetes mellitus (ISO)

Type 2 Diabetes Mellitus 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aflatoxin metabolic process (ISO)

cellular response to hormone stimulus (ISO)

cholesterol homeostasis (IEA,ISO)

cholesterol metabolic process (IEA,ISO)

cholesterol transport (IEA,ISO)

chylomicron remnant clearance (ISO)

chylomicron remodeling (ISO)

circadian rhythm (ISO)

developmental growth (ISO)

fatty acid biosynthetic process (IEA)

fatty acid metabolic process (ISO)

glycerophospholipid catabolic process (ISO)

heparan sulfate proteoglycan biosynthetic process (ISO)

high-density lipoprotein particle remodeling (IEA,ISO)

lipid catabolic process (IEA)

lipid metabolic process (IEA)

liver development (ISO)

low-density lipoprotein particle clearance (ISO)

low-density lipoprotein particle remodeling (IEA,ISO)

neutral lipid catabolic process (ISO)

phosphatidic acid metabolic process (ISO)

phosphatidylcholine metabolic process (ISO)

phosphatidylethanolamine metabolic process (ISO)

phosphatidylserine metabolic process (ISO)

regulation of plasma lipoprotein particle levels (ISO)

response to acetate (ISO)

response to amino acid (ISO)

response to calcium ion (ISO)

response to carbohydrate (ISO)

response to copper ion (ISO)

response to fatty acid (ISO)

response to glucocorticoid (ISO)

response to hormone (ISO)

response to hypoxia (ISO)

response to lipid (ISO)

response to magnesium ion (ISO)

response to nutrient levels (ISO)

response to organic cyclic compound (ISO)

response to peptide hormone (ISO)

response to xenobiotic stimulus (ISO)

triglyceride catabolic process (IEA)

triglyceride homeostasis (IEA)

triglyceride metabolic process (ISO)

very-low-density lipoprotein particle remodeling (IEA,ISO)

Cellular Component

cell surface (ISO)

early endosome (ISO)

extracellular region (IEA)

extracellular space (IEA,ISO)

high-density lipoprotein particle (IEA)

late endosome (ISO)

microvillus (ISO)

Molecular Function

acetylesterase activity (ISO)

acyltransferase activity (ISO)

apolipoprotein binding (ISO)

chylomicron binding (ISO)

heparan sulfate proteoglycan binding (ISO)

heparin binding (IEA,ISO)

identical protein binding (ISO)

lipase activity (IEA)

lipid binding (ISO)

low-density lipoprotein particle binding (ISO)

lysophospholipase activity (ISO)

metal ion binding (IEA)

monoacylglycerol lipase activity (ISO)

phospholipase A1 activity (IEA,ISO)

protein binding (ISO)

triacylglycerol lipase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

D-glycericacidemia pathway (ISO)

familial lipoprotein lipase deficiency pathway (ISO)

glycerol kinase deficiency pathway (ISO)

glycerolipid metabolic pathway (ISO)

lipoprotein metabolic pathway (ISO)

reverse cholesterol transport pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

LIPC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	23,432,460 - 23,584,037 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	23,432,493 - 23,584,037 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	23,404,560 - 23,555,900 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	23,597,357 - 23,749,167 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	23,597,357 - 23,852,590 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	23,523,240 - 23,674,537 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	23,608,314 - 23,759,924 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	23,750,266 - 23,901,905 (+)	NCBI		UU_Cfam_GSD_1.0

LIPC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	58,431,991 - 58,569,844 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	58,410,569 - 58,569,844 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	58,724,190 - 58,862,043 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	56,511,467 - 56,648,364 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	56,511,466 - 56,648,364	NCBI
Celera	15	35,612,421 - 35,749,365 (+)	NCBI		Celera
Cytogenetic Map	15	q21.3	NCBI
HuRef	15	35,547,160 - 35,684,065 (+)	NCBI		HuRef
CHM1_1	15	58,842,117 - 58,978,999 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	56,233,960 - 56,371,844 (+)	NCBI		T2T-CHM13v2.0

Lipc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	70,705,410 - 70,859,503 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	70,705,410 - 70,859,508 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	70,798,128 - 70,952,221 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	70,798,128 - 70,952,226 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	70,645,935 - 70,782,615 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	70,597,345 - 70,734,025 (-)	NCBI		MGSCv36	mm8
Celera	9	68,015,071 - 68,150,792 (-)	NCBI		Celera
Cytogenetic Map	9	D	NCBI
cM Map	9	39.57	NCBI

Lipc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	80,390,470 - 80,516,463 (-)	NCBI		GRCr8
mRatBN7.2	8	71,509,633 - 71,635,663 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	71,509,635 - 71,635,464 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	77,037,525 - 77,163,423 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	75,310,544 - 75,436,448 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	73,147,548 - 73,273,430 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	77,272,582 - 77,398,485 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	77,272,570 - 77,398,248 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	75,686,187 - 75,812,459 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	75,323,442 - 75,450,353 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	75,342,496 - 75,469,407 (-)	NCBI
Celera	8	70,101,863 - 70,227,531 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

Lipc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	15,948,187 - 16,048,766 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	15,947,869 - 16,062,449 (-)	NCBI	ChiLan1.0	ChiLan1.0

LIPC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	47,671,866 - 47,832,541 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	51,840,618 - 52,014,831 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	37,363,507 - 37,537,723 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	55,688,414 - 55,847,005 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	55,814,017 - 55,847,005 (+)	Ensembl	panpan1.1		panPan2

Lipc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	101,755,855 - 101,885,658 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	19,703,236 - 19,733,686 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	19,604,083 - 19,733,721 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LIPC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	113,433,687 - 113,583,963 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	113,433,684 - 113,604,139 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	125,418,537 - 125,667,649 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LIPC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	24,946,843 - 25,109,338 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	24,946,673 - 25,087,921 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	116,211,906 - 116,373,902 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lipc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	13,342,357 - 13,455,055 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	13,342,469 - 13,468,120 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in LIPC
2486 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium			6	6		6
Low	4	1	11		6		6		6		9	5
Below cutoff	1	4	5					4	6	8	1	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001287090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022412485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF094581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000365	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000026227 ⟹ ENSCAFP00000024355

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	30	23,432,493 - 23,579,247 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000036567 ⟹ ENSCAFP00000031965

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	30	23,432,493 - 23,584,037 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000067396 ⟹ ENSCAFP00000049916

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	30	23,432,493 - 23,584,037 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845027345 ⟹ ENSCAFP00845021524

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	30	23,597,357 - 23,852,590 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845027412 ⟹ ENSCAFP00845021575

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	30	23,597,357 - 23,749,167 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845027477 ⟹ ENSCAFP00845021618

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	30	23,597,357 - 23,749,167 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845027498 ⟹ ENSCAFP00845021635

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	30	23,597,357 - 23,744,514 (+)	Ensembl

RefSeq Acc Id:

NM_001287090 ⟹ NP_001274019

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	30	23,432,493 - 23,584,037 (+)	NCBI
Dog10K_Boxer_Tasha	30	23,404,560 - 23,555,900 (+)	NCBI
ROS_Cfam_1.0	30	23,597,357 - 23,749,167 (+)	NCBI
UMICH_Zoey_3.1	30	23,523,240 - 23,674,537 (+)	NCBI
UNSW_CanFamBas_1.0	30	23,608,314 - 23,759,924 (+)	NCBI
UU_Cfam_GSD_1.0	30	23,750,266 - 23,901,905 (+)	NCBI

Sequence:

show sequence

GCCAGCTAACTCTGTCGCTTTGATCCCCCTCATGGAAGCAAACGACTTATTTGGGCCACCTAAA
TACTTAATGAATTAAATGGAAAACGACACGGTGATTCCTGACAGGGCTGAATTTAAGTCAAGCT
GTGAAACTCCACAGCGCAGCCAGAAGTAGAGCTGGACCAGTCGAGCTGAAACCTGACCACTGCT
TCTCAGCAATTTTACTAAATTAGCAAGAAGACCTCGGACCCCGGGTGAGACAGGAGAAATGGAA
AGTCCCCCATGTGTCTCTATTTTCTTGGTTTTGTGCATCTTTATCCAATCAAGTGCCCATGGAC
AAAGCCTGGGACTAGAGCCATTTGGAAGAAGATTGAGAGCTGCTGAGACAATGGAAGCATCGCA
GGAGACAAAGACCAGATTCCTGCTTTTTGAAGAAGAAAGGGATAAGGGCTGTCAGATTCAACTG
AATCACCCAGACACGTTACAGCAGTGTGGCTTCAACTCCTCTCTGCCCCTGGTGATGATAATCC
ACGGGTGGACGGTGGACGGCCTCCTGGAAAGCTGGATTTGGCAGATGGTCGCCGCACTGAAGTC
TGGACTGGCCCAGCCGGTGAACGTGGTGCTGGCTGACTGGCTCACCCTGGCCTACCACCACTAC
ACCGTCGCCGTCCGCAACACCCGCCTTGTGGGCCAGGAGGTGGCAGCTCTCATCCTGTGGCTGG
AGGAATCTGCCCAATTTTCTCGAAGCAATGTTCATCTAATTGGGTATAGCCTGGGCGCACATGT
CTCAGGATTCGCTGGCAATTACATTGGCGGAAAGCACAAGATTGGGAGAATTACAGGGCTGGAC
GCTGCAGGCCCTTTGTTTGAGGGATCTTCGCCCAACGACCGTCTTTCACCAGATGATGCCGATT
TTGTGGACGCCATTCACACCTTCACCCGGGAGCACATGGGCCTGAGTGTGGGCATCAAACAGCC
CATAGCACACTACGACTTCTACCCCAATGGGGGCTACTTCCAGCCTGGCTGCCACTTCCTAGAG
CTCTACAAACATATTACCAAGCATGGCTTAACTGCCATCACGCAGACCATAAAATGCTCCCACG
AGCGGTCGGTGCACCTCTTCATCGACTCCTTGCTGCACCCCAGCCTGCAGAGCACGGCCTACCA
GTGCGGCGACATGGACAGCTTCAGCCAGGGCCTGTGCCTGAGCTGCAAGAGAGGCCGCCGCTGC
AACACGCTGGGCTACCACGCCCGCCGCGGGCCGCAGAGCAGGAAAAGCAAGAGGCTCTTCCTCG
CCACGCGCGCCCAGTCCCCCTTCAAAGTGTATCATTACCAGTTCAAGATCCAGTTCATCAACCA
ACTTGAGAAACCAGTAGAACCAACTTTTACCATGACACTCCTTGGAACAAAAGAGGAAAACCAG
AAAATTACCATCACTCTGGATGAAGAAATTACTAGTAATAAAACCTATTCCTTTCTTATCACAC
TGGATTTGGATATTGGTGAGCTGGTCATGATCAAGTTCAAGTGGGAAAATGGCTCAGTATGGAC
CAATGTCTGGAACACGGTCCAAACCATCATCCCATGGAGCAGGGGGCCCCTCTACTCAGGCCTT
GTTGTAAACACCATCAAAGTCAAAGCAGGAGAAACCCAACAACGAATGGCATTTTGCTCAGAAA
ACATGGATGGGCAACAGCTCCCCCAAACCCAGGAGAAAACCTTTGTGAGGTGCGACATAAACTC
TCAAAAATTGAAGAGGAAGATCAGATGAGCTTTCATGAAGCCCCGGCGGGAAGAATAAATGATC
TGATGCCTCATCTGGAATGGTTACTTTCTTTGGAAACCCAAGTTATATAAACAATCTTGCATAA
AGTTTAAACAAAGTTTAGCTTCAAGGGAGGAGTGTGTTTCACTATTCTAAACTGAACAGTTTAA
AAAACTATATTATGTAACAGTATTCAAATATTGGTGTAACTAAAAATTTCCCGATTGTATCTTT
GATTAAATGGTAATATATGCAAACATAAGTACCAAGAAGAGCCATTATAAATCCACTGTCCTGA
GTTAAAATGTCTTTTACAATTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001274019	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC69882	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000024355.4
	ENSCAFP00000031965.2
	ENSCAFP00000049916.1
	ENSCAFP00000071308.1
	ENSCAFP00030018231.1
	ENSCAFP00030018279.1
	ENSCAFP00030018366.1
	ENSCAFP00040042363.1
	ENSCAFP00040042366.1
	ENSCAFP00040042367.1
	ENSCAFP00845021524.1
	ENSCAFP00845021575
	ENSCAFP00845021575.1
	ENSCAFP00845021618.1
	ENSCAFP00845021635.1

RefSeq Acc Id:	NP_001274019 ⟸ NM_001287090
- Peptide Label:	precursor
- UniProtKB:	A0A8C0TWC6 (UniProtKB/TrEMBL), A0A8C0KFR8 (UniProtKB/TrEMBL), A0A8I3P549 (UniProtKB/TrEMBL), A0A8P0SPQ0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MESPPCVSIFLVLCIFIQSSAHGQSLGLEPFGRRLRAAETMEASQETKTRFLLFEEERDKGCQI QLNHPDTLQQCGFNSSLPLVMIIHGWTVDGLLESWIWQMVAALKSGLAQPVNVVLADWLTLAYH HYTVAVRNTRLVGQEVAALILWLEESAQFSRSNVHLIGYSLGAHVSGFAGNYIGGKHKIGRITG LDAAGPLFEGSSPNDRLSPDDADFVDAIHTFTREHMGLSVGIKQPIAHYDFYPNGGYFQPGCHF LELYKHITKHGLTAITQTIKCSHERSVHLFIDSLLHPSLQSTAYQCGDMDSFSQGLCLSCKRGR RCNTLGYHARRGPQSRKSKRLFLATRAQSPFKVYHYQFKIQFINQLEKPVEPTFTMTLLGTKEE NQKITITLDEEITSNKTYSFLITLDLDIGELVMIKFKWENGSVWTNVWNTVQTIIPWSRGPLYS GLVVNTIKVKAGETQQRMAFCSENMDGQQLPQTQEKTFVRCDINSQKLKRKIR hide sequence

Ensembl Acc Id:

ENSCAFP00000049916 ⟸ ENSCAFT00000067396

Ensembl Acc Id:

ENSCAFP00000024355 ⟸ ENSCAFT00000026227

Ensembl Acc Id:

ENSCAFP00000031965 ⟸ ENSCAFT00000036567

Ensembl Acc Id:

ENSCAFP00845021618 ⟸ ENSCAFT00845027477

Ensembl Acc Id:

ENSCAFP00845021524 ⟸ ENSCAFT00845027345

Ensembl Acc Id:

ENSCAFP00845021635 ⟸ ENSCAFT00845027498

Ensembl Acc Id:

ENSCAFP00845021575 ⟸ ENSCAFT00845027412

Protein Domains

PLAT

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000016560	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030011255	UniProtKB/TrEMBL
	ENSCAFG00040025923	UniProtKB/TrEMBL
	ENSCAFG00845015307	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000026227.4	UniProtKB/TrEMBL
	ENSCAFT00000036567.5	UniProtKB/TrEMBL
	ENSCAFT00000067396.2	UniProtKB/TrEMBL
	ENSCAFT00000105368.1	UniProtKB/TrEMBL
	ENSCAFT00030020894.1	UniProtKB/TrEMBL
	ENSCAFT00030020958.1	UniProtKB/TrEMBL
	ENSCAFT00030021061.1	UniProtKB/TrEMBL
	ENSCAFT00040048496.1	UniProtKB/TrEMBL
	ENSCAFT00040048499.1	UniProtKB/TrEMBL
	ENSCAFT00040048500.1	UniProtKB/TrEMBL
	ENSCAFT00845027345.1	UniProtKB/TrEMBL
	ENSCAFT00845027412	ENTREZGENE
	ENSCAFT00845027412.1	UniProtKB/TrEMBL
	ENSCAFT00845027477.1	UniProtKB/TrEMBL
	ENSCAFT00845027498.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/TrEMBL
	PLAT/LH2 domain	UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/TrEMBL
	Lipase/vitellogenin	UniProtKB/TrEMBL
	Lipase_hep	UniProtKB/TrEMBL
	Lipase_LIPH	UniProtKB/TrEMBL
	Lipase_N	UniProtKB/TrEMBL
	PLAT/LH2_dom	UniProtKB/TrEMBL
	PLAT/LH2_dom_sf	UniProtKB/TrEMBL
	TAG_lipase	UniProtKB/TrEMBL
KEGG Report	cfa:478320	UniProtKB/TrEMBL
NCBI Gene	LIPC	ENTREZGENE
PANTHER	PTHR11610	UniProtKB/TrEMBL
	PTHR11610:SF2	UniProtKB/TrEMBL
Pfam	Lipase	UniProtKB/TrEMBL
	PLAT	UniProtKB/TrEMBL
PIRSF	Lipoprotein_lipase_LIPH	UniProtKB/TrEMBL
PRINTS	HEPLIPASE	UniProtKB/TrEMBL
	TAGLIPASE	UniProtKB/TrEMBL
PROSITE	PLAT	UniProtKB/TrEMBL
SMART	LH2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49723	UniProtKB/TrEMBL
	SSF53474	UniProtKB/TrEMBL
UniProt	A0A8C0KFR8	ENTREZGENE
	A0A8C0TU01_CANLF	UniProtKB/TrEMBL
	A0A8C0TWC6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0U062_CANLF	UniProtKB/TrEMBL
	A0A8I3NWX1_CANLF	UniProtKB/TrEMBL
	A0A8I3NX32_CANLF	UniProtKB/TrEMBL
	A0A8I3P025_CANLF	UniProtKB/TrEMBL
	A0A8I3P549	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NZS9_CANLF	UniProtKB/TrEMBL
	A0A8P0SKL0_CANLF	UniProtKB/TrEMBL
	A0A8P0SPQ0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0TP81_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:42694	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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RGD Manual Annotations

Imported Annotations - SMPDB