LIPC (lipase C, hepatic type) - Rat Genome Database

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Gene: LIPC (lipase C, hepatic type) Canis lupus familiaris
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Symbol: LIPC
Name: lipase C, hepatic type
RGD ID: 12159133
Description: ENCODES a protein that exhibits acylglycerol lipase activity (ortholog); acyltransferase activity (ortholog); apolipoprotein binding (ortholog); INVOLVED IN cellular response to hormone stimulus (ortholog); cholesterol homeostasis (ortholog); cholesterol metabolic process (ortholog); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); Bloom syndrome (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hepatic triacylglycerol lipase; hepatic triglyceride lipase; HTGL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,432,460 - 23,584,037 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,432,493 - 23,584,037 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,404,560 - 23,555,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03023,597,357 - 23,749,167 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3023,597,357 - 23,852,590 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13023,523,240 - 23,674,537 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03023,608,314 - 23,759,924 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03023,750,266 - 23,901,905 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to hormone stimulus  (ISO)
cholesterol homeostasis  (IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
cholesterol transport  (IEA,ISO)
chylomicron remnant clearance  (ISO)
chylomicron remodeling  (ISO)
circadian rhythm  (ISO)
developmental growth  (ISO)
fatty acid biosynthetic process  (IBA,IEA)
fatty acid metabolic process  (ISO)
glycerophospholipid catabolic process  (ISO)
heparan sulfate proteoglycan biosynthetic process  (ISO)
high-density lipoprotein particle remodeling  (IEA,ISO)
lipid catabolic process  (IBA,IEA)
lipid metabolic process  (IEA)
liver development  (ISO)
low-density lipoprotein particle clearance  (ISO)
low-density lipoprotein particle remodeling  (IEA,ISO)
neutral lipid catabolic process  (ISO)
phosphatidic acid metabolic process  (ISO)
phosphatidylcholine metabolic process  (ISO)
phosphatidylethanolamine metabolic process  (ISO)
phosphatidylserine metabolic process  (ISO)
regulation of plasma lipoprotein particle levels  (ISO)
response to acetate  (ISO)
response to amino acid  (ISO)
response to calcium ion  (ISO)
response to carbohydrate  (ISO)
response to copper ion  (ISO)
response to fatty acid  (ISO)
response to glucocorticoid  (ISO)
response to hormone  (ISO)
response to hypoxia  (ISO)
response to inorganic substance  (ISO)
response to lipid  (ISO)
response to magnesium ion  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to xenobiotic stimulus  (ISO)
triglyceride catabolic process  (IBA,IEA)
triglyceride homeostasis  (IEA)
triglyceride metabolic process  (ISO)
very-low-density lipoprotein particle remodeling  (IEA,ISO)

Cellular Component

References

Genomics

Comparative Map Data
LIPC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,432,460 - 23,584,037 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,432,493 - 23,584,037 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,404,560 - 23,555,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03023,597,357 - 23,749,167 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3023,597,357 - 23,852,590 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13023,523,240 - 23,674,537 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03023,608,314 - 23,759,924 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03023,750,266 - 23,901,905 (+)NCBIUU_Cfam_GSD_1.0
LIPC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381558,410,554 - 58,569,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1558,410,569 - 58,569,844 (+)EnsemblGRCh38hg38GRCh38
GRCh371558,724,190 - 58,862,043 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,511,467 - 56,648,364 (+)NCBINCBI36Build 36hg18NCBI36
Build 341556,511,466 - 56,648,364NCBI
Celera1535,612,421 - 35,749,365 (+)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1535,547,160 - 35,684,065 (+)NCBIHuRef
CHM1_11558,842,117 - 58,978,999 (+)NCBICHM1_1
T2T-CHM13v2.01556,233,960 - 56,371,844 (+)NCBIT2T-CHM13v2.0
Lipc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39970,705,410 - 70,859,503 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl970,705,410 - 70,859,508 (-)EnsemblGRCm39 Ensembl
GRCm38970,798,128 - 70,952,221 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl970,798,128 - 70,952,226 (-)EnsemblGRCm38mm10GRCm38
MGSCv37970,645,935 - 70,782,615 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36970,597,345 - 70,734,025 (-)NCBIMGSCv36mm8
Celera968,015,071 - 68,150,792 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.57NCBI
Lipc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2871,509,633 - 71,635,663 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,509,635 - 71,635,464 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0877,272,582 - 77,398,485 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,272,570 - 77,398,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,686,187 - 75,812,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,323,442 - 75,450,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1875,342,496 - 75,469,407 (-)NCBI
Celera870,101,863 - 70,227,531 (+)NCBICelera
Cytogenetic Map8q24NCBI
Lipc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545015,948,187 - 16,048,766 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545015,947,869 - 16,062,449 (-)NCBIChiLan1.0ChiLan1.0
LIPC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11555,688,414 - 55,847,005 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1555,814,017 - 55,847,005 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01537,363,507 - 37,537,723 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Lipc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640101,755,855 - 101,885,658 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647119,604,083 - 19,733,721 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIPC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,433,687 - 113,583,963 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,433,684 - 113,604,139 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21125,418,537 - 125,667,649 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIPC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12624,946,843 - 25,109,338 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2624,946,673 - 25,087,921 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048116,211,906 - 116,373,902 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lipc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478113,342,357 - 13,455,055 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478113,342,469 - 13,468,120 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6
Low 4 1 11 6 6 6 9 5
Below cutoff 1 4 5 4 6 8 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000026227   ⟹   ENSCAFP00000024355
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3023,432,493 - 23,579,247 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000036567   ⟹   ENSCAFP00000031965
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3023,432,493 - 23,584,037 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000067396   ⟹   ENSCAFP00000049916
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3023,432,493 - 23,584,037 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845027345   ⟹   ENSCAFP00845021524
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3023,597,357 - 23,852,590 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845027412   ⟹   ENSCAFP00845021575
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3023,597,357 - 23,749,167 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845027477   ⟹   ENSCAFP00845021618
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3023,597,357 - 23,749,167 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845027498   ⟹   ENSCAFP00845021635
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3023,597,357 - 23,744,514 (+)Ensembl
RefSeq Acc Id: NM_001287090   ⟹   NP_001274019
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13023,432,493 - 23,584,037 (+)NCBI
Dog10K_Boxer_Tasha3023,404,560 - 23,555,900 (+)NCBI
ROS_Cfam_1.03023,597,357 - 23,749,167 (+)NCBI
UMICH_Zoey_3.13023,523,240 - 23,674,537 (+)NCBI
UNSW_CanFamBas_1.03023,608,314 - 23,759,924 (+)NCBI
UU_Cfam_GSD_1.03023,750,266 - 23,901,905 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001274019 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC69882 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001274019   ⟸   NM_001287090
- Peptide Label: precursor
- UniProtKB: A0A8C0TWC6 (UniProtKB/TrEMBL),   A0A8C0KFR8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000049916   ⟸   ENSCAFT00000067396
RefSeq Acc Id: ENSCAFP00000024355   ⟸   ENSCAFT00000026227
RefSeq Acc Id: ENSCAFP00000031965   ⟸   ENSCAFT00000036567
RefSeq Acc Id: ENSCAFP00845021618   ⟸   ENSCAFT00845027477
RefSeq Acc Id: ENSCAFP00845021524   ⟸   ENSCAFT00845027345
RefSeq Acc Id: ENSCAFP00845021635   ⟸   ENSCAFT00845027498
RefSeq Acc Id: ENSCAFP00845021575   ⟸   ENSCAFT00845027412
Protein Domains
PLAT

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
30 23563451 23563452 C T snv Lagotto Romagnolo (LR1030)
30 23563480 23563481 C G snv Lagotto Romagnolo (LR1030)
30 23563527 23563528 T A snv Lagotto Romagnolo (LR390), Doberman Pinscher (DO159), Lagotto Romagnolo (LR1030)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016560 Ensembl
  ENSCAFG00030011255 UniProtKB/TrEMBL
  ENSCAFG00040025923 UniProtKB/TrEMBL
  ENSCAFG00845015307 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030018231.1 UniProtKB/TrEMBL
  ENSCAFP00030018279.1 UniProtKB/TrEMBL
  ENSCAFP00030018366.1 UniProtKB/TrEMBL
  ENSCAFP00040042363 UniProtKB/TrEMBL
  ENSCAFP00040042366 UniProtKB/TrEMBL
  ENSCAFP00040042367 UniProtKB/TrEMBL
  ENSCAFP00845021524.1 UniProtKB/TrEMBL
  ENSCAFP00845021575 ENTREZGENE
  ENSCAFP00845021575.1 UniProtKB/TrEMBL
  ENSCAFP00845021618.1 UniProtKB/TrEMBL
  ENSCAFP00845021635.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030020894.1 UniProtKB/TrEMBL
  ENSCAFT00030020958.1 UniProtKB/TrEMBL
  ENSCAFT00030021061.1 UniProtKB/TrEMBL
  ENSCAFT00040048496 UniProtKB/TrEMBL
  ENSCAFT00040048499 UniProtKB/TrEMBL
  ENSCAFT00040048500 UniProtKB/TrEMBL
  ENSCAFT00845027345.1 UniProtKB/TrEMBL
  ENSCAFT00845027412 ENTREZGENE
  ENSCAFT00845027412.1 UniProtKB/TrEMBL
  ENSCAFT00845027477.1 UniProtKB/TrEMBL
  ENSCAFT00845027498.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Lipase/vitellogenin UniProtKB/TrEMBL
  Lipase_hep UniProtKB/TrEMBL
  Lipase_LIPH UniProtKB/TrEMBL
  Lipase_N UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/TrEMBL
  TAG_lipase UniProtKB/TrEMBL
NCBI Gene LIPC ENTREZGENE
PANTHER PTHR11610 UniProtKB/TrEMBL
  PTHR11610:SF2 UniProtKB/TrEMBL
Pfam Lipase UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
PIRSF Lipoprotein_lipase_LIPH UniProtKB/TrEMBL
PRINTS HEPLIPASE UniProtKB/TrEMBL
  TAGLIPASE UniProtKB/TrEMBL
PROSITE PLAT UniProtKB/TrEMBL
SMART LH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF49723 UniProtKB/TrEMBL
  SSF53474 UniProtKB/TrEMBL
UniProt A0A8C0KFR8 ENTREZGENE
  A0A8C0TU01_CANLF UniProtKB/TrEMBL
  A0A8C0TWC6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0U062_CANLF UniProtKB/TrEMBL
  A0A8I3NWX1_CANLF UniProtKB/TrEMBL
  A0A8I3NX32_CANLF UniProtKB/TrEMBL
  A0A8I3P025_CANLF UniProtKB/TrEMBL
  A0A8I3P549_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:42694 ENTREZGENE