LIPC (lipase C, hepatic type) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: LIPC (lipase C, hepatic type) Sus scrofa
Analyze
Symbol: LIPC
Name: lipase C, hepatic type
RGD ID: 13847054
Description: ENCODES a protein that exhibits acetylesterase activity (ortholog); acyltransferase activity (ortholog); apolipoprotein binding (ortholog); INVOLVED IN aflatoxin metabolic process (ortholog); cellular response to hormone stimulus (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); Bloom syndrome (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hepatic triacylglycerol lipase; lipase, hepatic
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,433,687 - 113,583,963 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,433,684 - 113,604,139 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21125,418,537 - 125,667,649 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aflatoxin metabolic process  (ISO)
cellular response to hormone stimulus  (ISO)
cholesterol homeostasis  (IBA,IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
cholesterol transport  (IEA,ISO)
chylomicron remnant clearance  (ISO)
chylomicron remodeling  (ISO)
circadian rhythm  (ISO)
developmental growth  (ISO)
fatty acid biosynthetic process  (IBA,IEA)
fatty acid metabolic process  (ISO)
glycerophospholipid catabolic process  (ISO)
heparan sulfate proteoglycan biosynthetic process  (ISO)
high-density lipoprotein particle remodeling  (IBA,IEA,ISO)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
liver development  (ISO)
low-density lipoprotein particle clearance  (ISO)
low-density lipoprotein particle remodeling  (IEA,ISO)
neutral lipid catabolic process  (ISO)
phosphatidic acid metabolic process  (ISO)
phosphatidylcholine metabolic process  (ISO)
phosphatidylethanolamine metabolic process  (ISO)
phosphatidylserine metabolic process  (ISO)
regulation of plasma lipoprotein particle levels  (ISO)
response to acetate  (ISO)
response to amino acid  (ISO)
response to calcium ion  (ISO)
response to carbohydrate  (ISO)
response to copper ion  (ISO)
response to fatty acid  (ISO)
response to glucocorticoid  (ISO)
response to hormone  (ISO)
response to hypoxia  (ISO)
response to lipid  (ISO)
response to magnesium ion  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to xenobiotic stimulus  (ISO)
triglyceride catabolic process  (IBA,IEA)
triglyceride homeostasis  (IEA)
triglyceride metabolic process  (ISO)
very-low-density lipoprotein particle remodeling  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:21327595   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LIPC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,433,687 - 113,583,963 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,433,684 - 113,604,139 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21125,418,537 - 125,667,649 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIPC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381558,431,991 - 58,569,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1558,410,569 - 58,569,844 (+)EnsemblGRCh38hg38GRCh38
GRCh371558,724,190 - 58,862,043 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,511,467 - 56,648,364 (+)NCBINCBI36Build 36hg18NCBI36
Build 341556,511,466 - 56,648,364NCBI
Celera1535,612,421 - 35,749,365 (+)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1535,547,160 - 35,684,065 (+)NCBIHuRef
CHM1_11558,842,117 - 58,978,999 (+)NCBICHM1_1
T2T-CHM13v2.01556,233,960 - 56,371,844 (+)NCBIT2T-CHM13v2.0
Lipc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39970,705,410 - 70,859,503 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl970,705,410 - 70,859,508 (-)EnsemblGRCm39 Ensembl
GRCm38970,798,128 - 70,952,221 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl970,798,128 - 70,952,226 (-)EnsemblGRCm38mm10GRCm38
MGSCv37970,645,935 - 70,782,615 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36970,597,345 - 70,734,025 (-)NCBIMGSCv36mm8
Celera968,015,071 - 68,150,792 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.57NCBI
Lipc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8880,390,470 - 80,516,463 (-)NCBIGRCr8
mRatBN7.2871,509,633 - 71,635,663 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,509,635 - 71,635,464 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx877,037,525 - 77,163,423 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0875,310,544 - 75,436,448 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0873,147,548 - 73,273,430 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0877,272,582 - 77,398,485 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,272,570 - 77,398,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,686,187 - 75,812,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,323,442 - 75,450,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1875,342,496 - 75,469,407 (-)NCBI
Celera870,101,863 - 70,227,531 (+)NCBICelera
Cytogenetic Map8q24NCBI
Lipc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545015,948,187 - 16,048,766 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545015,947,869 - 16,062,449 (-)NCBIChiLan1.0ChiLan1.0
LIPC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21647,671,866 - 47,832,541 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11551,840,618 - 52,014,831 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01537,363,507 - 37,537,723 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11555,688,414 - 55,847,005 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1555,814,017 - 55,847,005 (+)Ensemblpanpan1.1panPan2
LIPC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,432,460 - 23,584,037 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,432,493 - 23,584,037 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,404,560 - 23,555,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03023,597,357 - 23,749,167 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3023,597,357 - 23,852,590 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13023,523,240 - 23,674,537 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03023,608,314 - 23,759,924 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03023,750,266 - 23,901,905 (+)NCBIUU_Cfam_GSD_1.0
Lipc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640101,755,855 - 101,885,658 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647119,703,236 - 19,733,686 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647119,604,083 - 19,733,721 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIPC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12624,946,843 - 25,109,338 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2624,946,673 - 25,087,921 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048116,211,906 - 116,373,902 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lipc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478113,342,357 - 13,455,055 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478113,342,469 - 13,468,120 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LIPC
3963 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000005077   ⟹   ENSSSCP00000004953
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1113,433,687 - 113,583,963 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000040535   ⟹   ENSSSCP00000050843
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1113,433,687 - 113,583,963 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000042325   ⟹   ENSSSCP00000045136
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1113,433,679 - 113,604,306 (-)Ensembl
RefSeq Acc Id: NM_001143714   ⟹   NP_001137186
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11113,433,684 - 113,583,726 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021063855   ⟹   XP_020919514
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11113,433,684 - 113,604,139 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021063893   ⟹   XP_020919552
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11113,433,684 - 113,583,958 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021063936   ⟹   XP_020919595
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11113,433,684 - 113,583,718 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021063961   ⟹   XP_020919620
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11113,433,684 - 113,583,710 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020919514   ⟸   XM_021063855
- Peptide Label: isoform X1
- UniProtKB: F1RZH2 (UniProtKB/TrEMBL),   A0A4X1TK78 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919552   ⟸   XM_021063893
- Peptide Label: isoform X1
- UniProtKB: F1RZH2 (UniProtKB/TrEMBL),   A0A4X1TK78 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001137186   ⟸   NM_001143714
- Peptide Label: precursor
- UniProtKB: B8XSI5 (UniProtKB/TrEMBL),   A0A4X1TK78 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919595   ⟸   XM_021063936
- Peptide Label: isoform X2
- UniProtKB: A0A287AMA2 (UniProtKB/TrEMBL),   A0A4X1TMQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919620   ⟸   XM_021063961
- Peptide Label: isoform X3
- UniProtKB: A0A8D0PRP0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000050843   ⟸   ENSSSCT00000040535
Ensembl Acc Id: ENSSSCP00000004953   ⟸   ENSSSCT00000005077
Ensembl Acc Id: ENSSSCP00000045136   ⟸   ENSSSCT00000042325
Protein Domains
PLAT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004596 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015069072 UniProtKB/TrEMBL
  ENSSSCG00025025105 UniProtKB/TrEMBL
  ENSSSCG00030038887 UniProtKB/TrEMBL
  ENSSSCG00035064102 UniProtKB/TrEMBL
  ENSSSCG00040066686 UniProtKB/TrEMBL
  ENSSSCG00045017660 UniProtKB/TrEMBL
  ENSSSCG00050071855 UniProtKB/TrEMBL
  ENSSSCG00055023971 UniProtKB/TrEMBL
  ENSSSCG00060006149 UniProtKB/TrEMBL
  ENSSSCG00065065839 UniProtKB/TrEMBL
  ENSSSCG00070010153 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005077 ENTREZGENE
  ENSSSCT00000005077.5 UniProtKB/TrEMBL
  ENSSSCT00000040535.3 UniProtKB/TrEMBL
  ENSSSCT00015092669.1 UniProtKB/TrEMBL
  ENSSSCT00025033920.1 UniProtKB/TrEMBL
  ENSSSCT00025034051.1 UniProtKB/TrEMBL
  ENSSSCT00025034160.1 UniProtKB/TrEMBL
  ENSSSCT00025034246.1 UniProtKB/TrEMBL
  ENSSSCT00030054183.1 UniProtKB/TrEMBL
  ENSSSCT00030054223.1 UniProtKB/TrEMBL
  ENSSSCT00030054280.1 UniProtKB/TrEMBL
  ENSSSCT00030054338.1 UniProtKB/TrEMBL
  ENSSSCT00035086248.1 UniProtKB/TrEMBL
  ENSSSCT00035086252.1 UniProtKB/TrEMBL
  ENSSSCT00035086266.1 UniProtKB/TrEMBL
  ENSSSCT00035086269.1 UniProtKB/TrEMBL
  ENSSSCT00040091235.1 UniProtKB/TrEMBL
  ENSSSCT00040091358.1 UniProtKB/TrEMBL
  ENSSSCT00040091661.1 UniProtKB/TrEMBL
  ENSSSCT00040091790.1 UniProtKB/TrEMBL
  ENSSSCT00045030108.1 UniProtKB/TrEMBL
  ENSSSCT00045030170.1 UniProtKB/TrEMBL
  ENSSSCT00045030240.1 UniProtKB/TrEMBL
  ENSSSCT00045030302.1 UniProtKB/TrEMBL
  ENSSSCT00050098056.1 UniProtKB/TrEMBL
  ENSSSCT00050098058.1 UniProtKB/TrEMBL
  ENSSSCT00050098062.1 UniProtKB/TrEMBL
  ENSSSCT00050098070.1 UniProtKB/TrEMBL
  ENSSSCT00055047252.1 UniProtKB/TrEMBL
  ENSSSCT00055047366.1 UniProtKB/TrEMBL
  ENSSSCT00055047464.1 UniProtKB/TrEMBL
  ENSSSCT00060007814.1 UniProtKB/TrEMBL
  ENSSSCT00060007817.1 UniProtKB/TrEMBL
  ENSSSCT00065090372.1 UniProtKB/TrEMBL
  ENSSSCT00065090400.1 UniProtKB/TrEMBL
  ENSSSCT00065090409.1 UniProtKB/TrEMBL
  ENSSSCT00070019798.1 UniProtKB/TrEMBL
  ENSSSCT00070019821.1 UniProtKB/TrEMBL
  ENSSSCT00070019830.1 UniProtKB/TrEMBL
  ENSSSCT00070019838.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Lipase/vitellogenin UniProtKB/TrEMBL
  Lipase_hep UniProtKB/TrEMBL
  Lipase_LIPH UniProtKB/TrEMBL
  Lipase_N UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/TrEMBL
  TAG_lipase UniProtKB/TrEMBL
KEGG Report ssc:100233189 UniProtKB/TrEMBL
NCBI Gene LIPC ENTREZGENE
PANTHER PTHR11610 UniProtKB/TrEMBL
  PTHR11610:SF2 UniProtKB/TrEMBL
Pfam Lipase UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
PIRSF Lipoprotein_lipase_LIPH UniProtKB/TrEMBL
PRINTS HEPLIPASE UniProtKB/TrEMBL
  TAGLIPASE UniProtKB/TrEMBL
PROSITE PLAT UniProtKB/TrEMBL
SMART LH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF49723 UniProtKB/TrEMBL
  SSF53474 UniProtKB/TrEMBL
UniProt A0A287AMA2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TK78 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TMQ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TMU4_PIG UniProtKB/TrEMBL
  A0A8D0PRP0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0WQT7_PIG UniProtKB/TrEMBL
  A0A8D0WUJ0_PIG UniProtKB/TrEMBL
  A0A8D1FM65_PIG UniProtKB/TrEMBL
  A0A8D1FU94_PIG UniProtKB/TrEMBL
  A0A8D1HW34_PIG UniProtKB/TrEMBL
  A0A8D1KJP2_PIG UniProtKB/TrEMBL
  A0A8D1NUL3_PIG UniProtKB/TrEMBL
  B8XSI5 ENTREZGENE, UniProtKB/TrEMBL
  F1RZH2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A287B348 UniProtKB/TrEMBL
VGNC ID VGNC:89738 ENTREZGENE