RGD Reference Report - Hepatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes. - Rat Genome Database

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Hepatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes.

Authors: Diard, P  Malewiak, MI  Lagrange, D  Griglio, S 
Citation: Diard P, etal., Biochem J. 1994 May 1;299 ( Pt 3):889-94.
RGD ID: 2308768
Pubmed: PMID:8192680   (View Abstract at PubMed)
PMCID: PMC1138104   (View Article at PubMed Central)

Active and heat-inactivated hepatic lipase stimulated to a statistically comparable extent the uptake of chylomicron remnant-like particles by isolated rat hepatocytes by 3-fold and 2.3-fold respectively and, likewise, their binding to hepatic plasma membranes by 5-fold and 4-fold respectively. Hepatic lipase may facilitate uptake of these particles, not only as a lipolytic enzyme, but also as a ligand anchored to extracellular glycosaminoglycans.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chylomicron remnant clearance  IDA 2308768 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Lipc  (lipase C, hepatic type)


Additional Information