RGD Reference Report - Down-regulation of hepatic lipase expression in experimental nephrotic syndrome. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Down-regulation of hepatic lipase expression in experimental nephrotic syndrome.

Authors: Liang, K  Vaziri, ND 
Citation: Liang K and Vaziri ND, Kidney Int. 1997 Jun;51(6):1933-7.
RGD ID: 2308789
Pubmed: PMID:9186885   (View Abstract at PubMed)

Hepatic lipase (HL) plays an important role in catabolism of chylomicron remnants, conversion of intermediate density lipoprotein (IDL) to low-density lipoprotein (LDL) and reverse transport of cholesterol to the liver. Several features of the nephrotic dyslipidemia point to the possible presence of HL deficiency. In an attempt to address this possibility, gene expression of HL was studied in rats with puromycin-induced nephrotic syndrome (NS). The results were compared with those obtained in a group of placebo-treated control animals. The NS group showed marked proteinuria, hypoalbuminemia, hypercholesterolemia, hypertriglyceridemia, normal creatinine clearance and normal hepatic tissue cholesterol concentration. HL activity of the liver tissue was reduced by approximately 60% in the NS group as compared to that found in the normal control group. The reduction of HL activity in the NS group was accompanied by a reduction of HL mRNA of virtually similar magnitude. HL activity of the liver tissue was inversely related to urinary protein excretion, serum cholesterol and serum triglyceride concentrations. In contrast, HL activity was directly related to serum albumin concentration and HL mRNA. No significant difference was observed in HL activity between the control group and the pre-nephrotic animals studied at days 1 and 5 following puromycin administration. This observation excludes an acute effect of puromycin as a possible cause of HL deficiency in the NS animals. Thus, NS in this model results in a marked down-regulation of HL expression which may, in part, contribute to the nephrotic dyslipidemia.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LIPCHumannephrotic syndrome  ISOLipc (Rattus norvegicus)protein and mRNA:reduced expression:liver (rat)RGD 
LipcRatnephrotic syndrome  IDA protein and mRNA:reduced expression:liver (rat)RGD 
LipcMousenephrotic syndrome  ISOLipc (Rattus norvegicus)protein and mRNA:reduced expression:liver (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Lipc  (lipase C, hepatic type)

Genes (Mus musculus)
Lipc  (lipase, hepatic)

Genes (Homo sapiens)
LIPC  (lipase C, hepatic type)


Additional Information