TSLP (thymic stromal lymphopoietin) - Rat Genome Database

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Gene: TSLP (thymic stromal lymphopoietin) Canis lupus familiaris
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Symbol: TSLP
Name: thymic stromal lymphopoietin
RGD ID: 12379440
Description: ENCODES a protein that exhibits interleukin-7 receptor binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); defense response to fungus (ortholog); defense response to Gram-negative bacterium (ortholog); ASSOCIATED WITH Albuminuria (ortholog); allergic contact dermatitis (ortholog); asthma (ortholog); FOUND IN extracellular region (ortholog); INTERACTS WITH cannabidiol; luteolin
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.131,502,469 - 1,507,696 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl31,503,188 - 1,507,696 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha32,907,296 - 2,971,755 (-)NCBI
ROS_Cfam_1.031,393,149 - 1,400,425 (-)NCBI
UMICH_Zoey_3.131,339,901 - 1,404,345 (-)NCBI
UNSW_CanFamBas_1.031,341,683 - 1,348,998 (-)NCBI
UU_Cfam_GSD_1.031,506,469 - 1,571,642 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
cannabidiol  (EXP)
luteolin  (EXP)

References
Additional References at PubMed
PMID:23331680  


Genomics

Comparative Map Data
TSLP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.131,502,469 - 1,507,696 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl31,503,188 - 1,507,696 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha32,907,296 - 2,971,755 (-)NCBI
ROS_Cfam_1.031,393,149 - 1,400,425 (-)NCBI
UMICH_Zoey_3.131,339,901 - 1,404,345 (-)NCBI
UNSW_CanFamBas_1.031,341,683 - 1,348,998 (-)NCBI
UU_Cfam_GSD_1.031,506,469 - 1,571,642 (-)NCBI
TSLP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385111,070,062 - 111,078,026 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5111,070,062 - 111,078,026 (+)EnsemblGRCh38hg38GRCh38
GRCh375110,405,760 - 110,413,724 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365110,435,289 - 110,441,623 (+)NCBINCBI36hg18NCBI36
Celera5106,353,329 - 106,359,661 (+)NCBI
Cytogenetic Map5q22.1NCBI
HuRef5105,584,896 - 105,592,841 (+)NCBIHuRef
CHM1_15109,839,103 - 109,847,047 (+)NCBICHM1_1
T2T-CHM13v2.05111,580,695 - 111,588,660 (+)NCBI
Tslp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,948,436 - 32,952,852 (+)NCBIGRCm39mm39
GRCm39 Ensembl1832,948,436 - 32,952,850 (+)Ensembl
GRCm381832,815,383 - 32,819,799 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,815,383 - 32,819,797 (+)EnsemblGRCm38mm10GRCm38
MGSCv371832,975,037 - 32,979,453 (+)NCBIGRCm37mm9NCBIm37
MGSCv361832,958,393 - 32,962,802 (+)NCBImm8
Celera1833,286,509 - 33,290,920 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.12NCBI
Tslp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21824,447,409 - 24,454,244 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1824,449,844 - 24,453,548 (+)Ensembl
Rnor_6.01825,613,601 - 25,618,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1825,613,831 - 25,617,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01825,326,396 - 25,333,230 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41825,268,082 - 25,274,214 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1824,198,059 - 24,202,524 (+)NCBICelera
Cytogenetic Map18p12NCBI
Tslp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554184,041,529 - 4,045,534 (-)NCBIChiLan1.0ChiLan1.0
TSLP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15112,242,490 - 112,249,200 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5112,242,490 - 112,250,130 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05106,440,136 - 106,446,849 (+)NCBIMhudiblu_PPA_v0panPan3
LOC101958191
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213156,110,394 - 156,115,633 (-)NCBI
SpeTri2.0NW_0049365315,495,872 - 5,500,462 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSLP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.12115,832,152 - 115,837,572 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22120,289,894 - 120,323,977 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103244324
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12314,419,820 - 14,423,331 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603464,056,775 - 64,060,255 (-)NCBIVero_WHO_p1.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 11 3 3 3 6 7 2
Low 1 5 11 3 6 3 3 6 6 3 4
Below cutoff 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000047306   ⟹   ENSCAFP00000040916
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl31,503,188 - 1,507,696 (-)Ensembl
RefSeq Acc Id: XM_005618038   ⟹   XP_005618095
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.131,502,469 - 1,507,696 (-)NCBI
Dog10K_Boxer_Tasha32,907,296 - 2,971,755 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038472695   ⟹   XP_038328623
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.131,339,901 - 1,404,345 (-)NCBI
RefSeq Acc Id: XM_038532126   ⟹   XP_038388054
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.031,506,469 - 1,571,642 (-)NCBI
RefSeq Acc Id: XM_038596382   ⟹   XP_038452310
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.031,341,683 - 1,348,998 (-)NCBI
RefSeq Acc Id: XM_038660521   ⟹   XP_038516449
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.031,393,149 - 1,400,425 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_005618095   ⟸   XM_005618038
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSCAFP00000040916   ⟸   ENSCAFT00000047306
RefSeq Acc Id: XP_038328623   ⟸   XM_038472695
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038452310   ⟸   XM_038596382
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038516449   ⟸   XM_038660521
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038388054   ⟸   XM_038532126
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000031005 Ensembl
  ENSCAFG00845003872 UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00845005551.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845006963.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.90 UniProtKB/TrEMBL
InterPro TSLP UniProtKB/TrEMBL
  TSLP_sf UniProtKB/TrEMBL
NCBI Gene TSLP ENTREZGENE
PANTHER PTHR38003 UniProtKB/TrEMBL
Pfam TSLP UniProtKB/TrEMBL
UniProt A0A8I3MRD5_CANLF UniProtKB/TrEMBL
  I1VWC7_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:53251 ENTREZGENE