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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Lung Reperfusion Injury
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Accession:DOID:9006827 term browser browse the term
Definition:Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the lung, including swelling; hemorrhage; necrosis; and damage from free radicals.
Synonyms:exact_synonym: Lung Ischemia-Reperfusion Injury


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Lung Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator treatment
ameliorates		 IEP
ISO		 RGD PMID:23953793 PMID:34238924 RGD:10054119, RGD:153350155 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP RGD PMID:23953793 RGD:10054119 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 treatment IEP RGD PMID:23953793 RGD:10054119 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Col1a1 collagen type I alpha 1 chain ISO mRNA:increased expression:lung (mouse) RGD PMID:34238924 RGD:153350155 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain ISO mRNA:increased expression:lung (mouse) RGD PMID:34238924 RGD:153350155 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Crebbp CREB binding protein ameliorates ISO RGD PMID:34238924 RGD:153350155 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Egr1 early growth response 1 treatment IMP
IEP		 RGD PMID:22878149 PMID:23232597 RGD:10395282, RGD:10395299 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Elane elastase, neutrophil expressed treatment IMP RGD PMID:17888675 RGD:10450582 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 ISO mRNA:increased expression:lung (rat) RGD PMID:35600952 RGD:155663563 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Hmgb1 high mobility group box 1 IEP protein:increased expression:lung RGD PMID:22115333 RGD:10402095 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 IEP protein:increased expression:lung RGD PMID:21227458 RGD:10755577 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IEP RGD PMID:22503847 RGD:7240537 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta ameliorates IDA
ISO
IEP		 protein:increased expression:lung (rat) RGD PMID:23142117 PMID:34238924 PMID:23122581 RGD:7183185, RGD:153350155, RGD:7204125 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 treatment IDA RGD PMID:24365768 RGD:10402797 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 ameliorates ISO RGD PMID:34238924 RGD:153350155 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ameliorates ISO RGD PMID:34238924 RGD:153350155 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP protein:increased activity:lung RGD PMID:18694576 RGD:5129703 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor treatment IEP RGD PMID:22503847 RGD:7240537 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nos3 nitric oxide synthase 3 IMP
ISO		 mRNA:increased expression:lung (mouse) RGD PMID:20815765 PMID:25382268 RGD:4892012, RGD:11533932 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP RGD PMID:21781312 RGD:6771212 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 IDA
IEP		 protein:increased expression:alveolar macrophage (rat) RGD PMID:21781312 PMID:16449942 RGD:6771212, RGD:11541083 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:19782612 RGD:11100035 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Serpine1 serpin family E member 1 treatment ISO
IDA		 protein:increased expression:plasma (human) RGD PMID:17846288 PMID:11606484 RGD:8547720, RGD:11080966 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Tlr4 toll-like receptor 4 treatment IEP RGD PMID:22115333 RGD:10402095 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor ameliorates IMP
ISO		 RGD PMID:17294835 PMID:34238924 RGD:4143397, RGD:153350155 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Zfp36 zinc finger protein 36 exacerbates ISO RGD PMID:34238924 RGD:153350155 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564 		JBrowse link
Chronic Lung Allograft Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 IEP mRNA:increased expression:lung RGD PMID:22305384 RGD:10395369 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    Wounds and Injuries 980
      Thoracic Injuries 301
        Lung Injury 295
          Lung Reperfusion Injury 27
            Chronic Lung Allograft Dysfunction 1
Path 2
Term Annotations click to browse term
  disease 18969
    disease of anatomical entity 18249
      cardiovascular system disease 5413
        vascular disease 4013
          ischemia 1500
            Reperfusion Injury 816
              Lung Reperfusion Injury 27
                Chronic Lung Allograft Dysfunction 1
paths to the root