RGD Reference Report - KGF-2 Protects against Lung Ischemia-Reperfusion Injury by Inhibiting Inflammation-Induced Damage to Endothelial Barrier Function. - Rat Genome Database

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KGF-2 Protects against Lung Ischemia-Reperfusion Injury by Inhibiting Inflammation-Induced Damage to Endothelial Barrier Function.

Authors: Xia, Fangfang  Jin, Zhousheng  Dong, Jiaojiao  Chen, Chaoxing  Cai, Yaoyao  Wang, Quanguang  Chen, Hongfei 
Citation: Xia F, etal., Evid Based Complement Alternat Med. 2022 May 11;2022:3055039. doi: 10.1155/2022/3055039. eCollection 2022.
RGD ID: 155663563
Pubmed: PMID:35600952   (View Abstract at PubMed)
PMCID: PMC9117025   (View Article at PubMed Central)
DOI: DOI:10.1155/2022/3055039   (Journal Full-text)

Lung ischemia-reperfusion injury (LIRI), which has a mortality rate of approximately 50%, is a popular topic in critical care research. Keratinocyte growth factor-2 (KGF-2) is secreted by mesenchymal cells, and it is effective in promoting the proliferation, migration, and differentiation of various epithelial cells. To date, however, only a few reports on KGF-2-related regulators in LIRI have been published. In the current study, an LIRI rat model is constructed, and the upregulation of the fibroblast growth factor receptor 2 (FGFR2) is observed in the LIRI rat model. In addition, LIRI induces NLRP1 inflammasome activation in vivo and in vitro, and KGF-2 inhibits LIRI-induced damage to pulmonary microvascular endothelial cells. Mechanistically, KGF-2 inhibits NLRP1 inflammasome and NF-κB activity. KGF-2 inhibition attenuates LIRI injury-induced damage to endothelial integrity. In conclusion, KGF-2 protects against LIRI by inhibiting inflammation-induced endothelial barrier damage.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
FGFR2HumanLung Reperfusion Injury  IEP mRNA:increased expression:lung (rat)RGD 
Fgfr2RatLung Reperfusion Injury  ISOFGFR2 (Homo sapiens)mRNA:increased expression:lung (rat)RGD 
Fgfr2MouseLung Reperfusion Injury  ISOFGFR2 (Homo sapiens)mRNA:increased expression:lung (rat)RGD 


Genes (Rattus norvegicus)
Fgfr2  (fibroblast growth factor receptor 2)

Genes (Mus musculus)
Fgfr2  (fibroblast growth factor receptor 2)

Genes (Homo sapiens)
FGFR2  (fibroblast growth factor receptor 2)